Results 141 to 150 of about 81,793 (267)

A-Kinase Anchoring Proteins in Cardiac Myocytes and Their Roles in Regulating Calcium Cycling. [PDF]

Cells, 2023
Subramanian H, Nikolaev VO.
europepmc   +1 more source

Ro5‐4864, a ligand of the mitochondrial translocator protein, protects against heart failure in mice via regulation of the p62‐Keap1‐Nrf2 axis

The Journal of Physiology, EarlyView.
Abstract figure legend Graphical abstract of the proposed Ro5‐4864 mechanism of action via p62‐Keap1‐Nrf2 axis in heart failure. TSPO, the 18‐kDa mitochondrial translocator protein of the outer mitochondrial membrane, can directly interact with p62 (also known as SQSTM1), which is crucial for the degradation of damaged mitochondria by autophagy ...
Daphne A. Diloretto, Phung N. Thai, Gabriela Grigorean, Veneese J. Brown, Tjien Dwyer, Nipavan Chiamvimonvat, Elena N. Dedkova, Saul Schaefer   +7 more
wiley   +1 more source

Effects of sugammadex and rocuronium on electro-mechanical activity of cardiac myocytes. [PDF]

Korean J Anesthesiol
Arun O, Ozturk N, Erkan O, Ozdemir S, Arun F, Yanardag SB, Ayaz M.   +6 more
europepmc   +1 more source

Necrotic cardiac myocytes skew macrophage polarization towards a classically activated phenotype. [PDF]

PLoS One, 2023
Jiang W, Adamo L, Lim K, Matkovich SJ, Evans S, Rocha-Resende C, Mann DL.   +6 more
europepmc   +1 more source

Catecholaminergic polymorphic ventricular tachycardia–linked ryanodine receptor variants exhibit domain‐specific calcium leak and calmodulin affinity properties

The Journal of Physiology, EarlyView.
Abstract figure legend Catecholaminergic polymorphic ventricular tachycardia (CPVT) variants in N terminal (NTD) and central domain (CD) but not pore domain induce a pathological RyR2 conformational shift upon protein kinase A (PKA) phosphorylation, similar to that seen in heart failure (HF), calcium/calmodulin‐dependent protein kinase II (CaMKII ...
Hitoshi Uchinoumi, Xiaoqiong Dong, Ivanita Stefanon, Yi Yang, Eduardo Hertel Ribeiro, Bengt Svensson, Xander H. T. Wehrens, Takeshi Yamamoto, Razvan L. Cornea, Robyn T. Rebbeck, Masafumi Yano, Donald M. Bers   +11 more
wiley   +1 more source

Myocardial Perfusion Defects in Hypertrophic Cardiomyopathy Mutation Carriers

Journal of the American Heart Association, EarlyView., 2021
Background Impaired myocardial blood flow (MBF) in the absence of epicardial coronary disease is a feature of hypertrophic cardiomyopathy (HCM). Although most evident in hypertrophied or scarred segments, reduced MBF can occur in apparently normal segments.
Rebecca K. Hughes, Claudia Camaioni, João B. Augusto, Kristopher Knott, Ellie Quinn, Gabriella Captur, Andreas Seraphim, George Joy, Petros Syrris, Perry M. Elliott, Saidi Mohiddin, Peter Kellman, Hui Xue, Luis R. Lopes, James C. Moon   +14 more
wiley   +1 more source

Loss of O-GlcNAcylation in cardiac myocytes triggers the integrated stress response, contributing to heart failure. [PDF]

J Biol Chem
Papanicolaou KN, Zhang W, Dunphy AJ, Zhong JC, Cho CY, Turner DR, Ashok D, Foster DB, O'Rourke B, Zachara NE.   +9 more
europepmc   +1 more source

Human induced pluripotent stem cell-derived cardiac myocytes and sympathetic neurons in disease modelling. [PDF]

Philos Trans R Soc Lond B Biol Sci, 2023
Li N, Edel M, Liu K, Denning C, Betts J, Neely OC, Li D, Paterson DJ.   +7 more
europepmc   +1 more source

14‐3‐3 proteins: Regulators of cardiac excitation–contraction coupling and stress responses

The Journal of Physiology, EarlyView.
Abstract figure legend 14‐3‐3 protein interactions in cardiac regulation. Schematic representation of 14‐3‐3 binding partners in excitation–contraction coupling, transcriptional regulation/development and stress response pathways. Asterisks indicate targets where the exact 14‐3‐3 binding site is unknown.
Heather C. Spooner, Rose E. Dixon
wiley   +1 more source

Alpha-actinin-1 promotes adhesion maturation and facilitates sarcomere assembly in cardiac myocytes. [PDF]

Mol Biol Cell
Hayes JB, Bainbridge AM, Willet AH, Burnette DT.   +3 more
europepmc   +1 more source