Results 331 to 340 of about 1,441,839 (397)

Repolarization adaptation to rapid change in heart rate in human models – a review

The Journal of Physiology, EarlyView.
Abstract figure legend This review focuses on non‐invasive assessment of repolarization duration and dispersion (heterogeneity) adaptation to change in heart rate (HR). HR was increased incrementally by left atrial pacing during an electrophysiology (EP) study and by a bolus injection of atropine and in a step up/down fashion by repeated right atrial ...
Lennart Bergfeldt, Karl‐Jonas Axelsson, Pia Dahlberg, Farzad Vahedi, Gunilla Lundahl, Lennart Gransberg   +5 more
wiley   +1 more source

Combined inhibition of atrial‐specific potassium currents as a possible anti‐arrhythmic drug therapy: A match made in silico

The Journal of Physiology, EarlyView.
Vladimír Sobota
wiley   +1 more source

Structural determinants of re‐entrant drivers in atrial fibrillation: insights from digital twins derived from 3D micrometre‐resolution imaging of human heart

The Journal of Physiology, EarlyView.
Abstract figure legend Digital heart models of human donor atria with cardiac co‐morbidities revealed that regions with AWT variation, aligned myofibres adjacent to disorganised zones and fibrotic borders promoted the localisation and stability of RDs. AWT had a global influence, whereas fibre orientation and fibrosis exerted chamber‐specific regional ...
Anuradha Kulathilaka, Roshan Sharma, James Kennelly, Ning Li, Jieyun Bai, Bruce H. Smaill, Mark L. Trew, Vadim V. Fedorov, Jichao Zhao   +8 more
wiley   +1 more source

Computational modelling of the pro‐ and antiarrhythmic effects of atrial high rate‐dependent trafficking of small‐conductance calcium‐activated potassium channels

The Journal of Physiology, EarlyView.
Abstract figure legend Small‐conductance calcium‐activated potassium (SK) channels are important for atrial repolarization and can be targeted for atrial‐specific antiarrhythmic treatments. We developed a computational model with a calcium sensor to study the effects of increased pacing rate (5 Hz), which enhances SK‐channel gating and forward ...
Stefan Meier, Dobromir Dobrev, Paul G. A. Volders, Jordi Heijman   +3 more
wiley   +1 more source

Atrial fibrosis in atrial fibrillation: Mechanisms, mapping techniques and clinical applications

The Journal of Physiology, EarlyView.
Abstract figure legend Summary of key aspects of atrial fibrosis in atrial fibrillation, highlighting atrial fibrosis as a hallmark of atrial fibrillation (AF). (1) Different types of fibrosis (blue), illustrating reparative and reactive fibrosis; (2) fibrosis detection techniques (green), illustrating late gadolinium enhancement cardiac magnetic ...
Caterina Vidal Horrach, Laura Bevis, Cynthia Nwanna, Alexander M Zolotarev, Mahmoud Ehnesh, Semhar Biniam Misghina, Sayed Al‐Aidarous, Shohreh Honarbakhsh, Caroline H. Roney   +8 more
wiley   +1 more source

In silico predictions of action potential propagation in doxorubicin cardiotoxicity: A parametric study using preclinical 3D magnetic resonance imaging‐based fibrotic left ventricle models

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic overview of the study's methodology and key findings. In a preclinical swine model, doxorubicin administration induced cardiotoxicity, characterized by diffuse fibrotic remodelling and altered electrical function, as assessed by magnetic resonance (MR) imaging and electrophysiological mapping.
Javier Villar‐Valero, Jairo Rodríguez Padilla, Nicolas Cedilnik, Buntheng Ly, Juan F. Gomez, Maxime Sermesant, Mihaela Pop, Beatriz Trenor   +7 more
wiley   +1 more source

Deciphering pro‐arrhythmogenic mechanisms of EPAC in human atrial cardiomyocytes

The Journal of Physiology, EarlyView.
Abstract figure legend This study aimed to investigate the effect of exchange proteins directly activated by cAMP (EPAC) on the regulation of human atrial cardiomyocyte electrophysiology and their potential involvement in the onset of atrial fibrillation (AF).
Arthur Boileve, Margaux Aize, Maximin Détrait, Laura Brard, Adrien Leboyer, Pierre‐Antoine Dupont, Alexandre Lebrun, Vladimir Saplacan, Christophe Simard, Fabien Brette, Frank Lezoualc'h, Laurent Sallé   +11 more
wiley   +1 more source

Nanoscale architecture and dynamics of Ca_V1.3 channel clusters in cardiac myocytes revealed by single channel nanoscopy

Schwenzer N, Tsukanov R, Kohl T, Basak S, Sobitov I, Sobitov I, Seibertz F, Kapoor R, Kapoor R, Voigt N, Enderlein J, Lehnart SE.   +11 more
europepmc   +1 more source