Results 1 to 10 of about 103,145 (303)

Dynamic expression and differential requirement of the myocyte fusogen Myomixer during distinct myogenic episodes in the zebrafish [PDF]

Biology Open
Sunandan Dhar, Serena Thomas, Hui Li Yeo, Timothy E. Saunders, Sudipto Roy   +4 more
doaj   +3 more sources

Optimization of Mechanosensitive Cross-Talk between Matrix Stiffness and Protein Density: Independent Matrix Properties Regulate Spreading Dynamics of Myocytes

Cells, 2022
Cells actively sense differences in topology, matrix elasticity and protein composition of the extracellular microenvironment and adapt their function and morphology.
Judith Brock, Julia Erhardt, Stephan A. Eisler, Marcel Hörning   +3 more
doaj   +1 more source

Uterine Endoplasmic Reticulum Stress and Its Unfolded Protein Response May Regulate Caspase 3 Activation in the Pregnant Mouse Uterus [PDF]

, 2013
We have previously proposed that uterine caspase-3 may modulate uterine contractility in a gestationally regulated fashion. The objective of this study was to determine the mechanism by which uterine caspase-3 is activated and consequently controlled in ...
Condon, Jennifer C., Jeyasuria, Pancharatnam, Kyathanahalli, Chandrashekara, Lydon, John P., Subedi, Kalpana, Suresh, Arvind   +5 more
core   +10 more sources

Calsarcin-2 May Play a Compensatory Role in the Development of Obese Sarcopenia

Biomedicines, 2023
Although obese sarcopenia is a major public health problem with increasing prevalence worldwide, the factors that contribute to the development of obese sarcopenia are still obscure.
Yu-Cheng Liang, Kai-Pi Cheng, Hsin-Yu Kuo, Chung-Teng Wang, Hsuan-Wen Chou, Kuan-Lin Huang, Hung-Tsung Wu, Horng-Yih Ou   +7 more
doaj   +1 more source

Changes in Cardiomyocyte Cell Cycle and Hypertrophic Growth During Fetal to Adult in Mammals

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
The failure of adult cardiomyocytes to reproduce themselves to repair an injury results in the development of severe cardiac disability leading to death in many cases.
Sanford P. Bishop, Yang Zhou, Yuji Nakada, Jianyi Zhang   +3 more
doaj   +1 more source

Dexamethasone Treatment Preserves the Structure of Adult Cardiac Explants and Supports Their Long-Term Contractility In Vitro

International Journal of Translational Medicine, 2023
Normal contractile function of the myocardium is essential for optimal cardiovascular health. Evaluating drug effects on cardiomyocyte function at the cellular level is difficult for long-term studies.
Leonard M. Eisenberg, Keerat Kaur, John M. Castillo, John G. Edwards, Carol A. Eisenberg   +4 more
doaj   +1 more source

Cysteamine improves growth and the GH/IGF axis in gilthead sea bream (Sparus aurata): in vivo and in vitro approaches

Frontiers in Endocrinology, 2023
Aquaculture is the fastest-growing food production sector and nowadays provides more food than extractive fishing. Studies focused on the understanding of how teleost growth is regulated are essential to improve fish production.
Albert Sánchez-Moya, Sara Balbuena-Pecino, Emilio J. Vélez, Miquel Perelló-Amorós, Irene García-Meilán, Ramón Fontanillas, Josep Àlvar Calduch-Giner, Jaume Pérez-Sánchez, Jaume Fernández-Borràs, Josefina Blasco, Joaquin Gutiérrez   +10 more
doaj   +1 more source

Anatomical-MRI Correlations in Adults and Children with Arrhythmogenic Right Ventricular Cardiomyopathy

Diagnostics, 2021
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a rare disease in which the right ventricular myocardium is replaced by islands of fibro-adipose tissue. Therefore, ventricular re-entry circuits can occur, predisposing the patient to ventricular
Simona-Sorana Cainap, Ilana Kovalenko, Edoardo Bonamano, Niclas Crousen, Alexandru Tirpe, Andrei Cismaru, Daniela Iacob, Cecilia Lazea, Alina Negru, Gabriel Cismaru   +9 more
doaj   +1 more source

Elimination of Mutant mtDNA by an Optimized mpTALEN Restores Differentiation Capacities of Heteroplasmic MELAS-iPSCs

Molecular Therapy: Methods & Clinical Development, 2021
Various mitochondrial diseases, including mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS), are associated with heteroplasmic mutations in mitochondrial DNA (mtDNA).
Naoki Yahata, Hiroko Boda, Ryuji Hata
doaj   +1 more source

Flecainide induces a sustained countercurrent dependent effect on RyR2 in permeabilized WT ventricular myocytes but not in intact cells

Frontiers in Pharmacology, 2023
Background and purpose: While flecainide is now an accepted treatment for arrhythmias associated with catecholaminergic polymorphic ventricular tachycardia (CPVT), its mechanism of action remains controversial.
Emma J. Steer, Zhaokang Yang, Moza M. Al-Owais, Hannah M. Kirton, Edward White, Derek S. Steele   +5 more
doaj   +1 more source