Results 1 to 10 of about 72,492 (253)

Environmental cues signal through circadian control of sarcomeric gene expression during cardiomyocyte hypertrophy [PDF]

Epigenetics
Environmental disruption alters circadian clock gene expression, increasing the risk of adverse cardiac events and suggesting cardiomyocyte-specific circadian responses to external stimuli.
Adrian Arrieta, Alexa Jennings, Pratiti Dasgupta, Natalie D. Gehred, Tatiana Gromova, Erik Sandoval, Kunhua Song, Mansoureh Eghbali, Matthew A. Fischer, Thomas M. Vondriska   +9 more
doaj   +2 more sources

Inhibition of Cyclophilin D Rescues Cardiac Function and Bioenergetic Defects Caused by Neonatal Hypoxia [PDF]

JACC: Basic to Translational Science
Summary: Increased oxygen levels at birth regulate myocyte bioenergetic and structural maturation controlled by mitochondrial cyclophilin D (CypD). We evaluated mechanisms of neonatal hypoxic cardiac dysfunction by exposing neonatal mice to 12% oxygen ...
Jonathan R. Burris, MD, Gisela Beutner, PhD, Min Yee, BS, Bartholomew V. Simon, MD, Michael F. Swartz, PAC, PhD, Kathryn B. Boudreau, BA, MS, Ethan D. Cohen, PhD, Chaitanya A. Kulkarni, PhD, Prottoy Hasan, PhD, Hongyue Wang, PhD, Karen L. de Mesy Bentley, MS, György Hajnóczky, MD, PhD, George M. Alfieris, MD, Eric M. Small, PhD, Paul S. Brookes, PhD, Michael A. O’Reilly, PhD, George A. Porter, Jr., MD, PhD   +16 more
doaj   +2 more sources

Biohybrid Soft Robots Powered by Myocyte: Current Progress and Future Perspectives

Micromachines, 2023
Myocyte-driven robots, a type of biological actuator that combines myocytes with abiotic systems, have gained significant attention due to their high energy efficiency, sensitivity, biocompatibility, and self-healing capabilities.
Wenguang Yang, Qinghao Guo
exaly   +3 more sources

Optimization of Mechanosensitive Cross-Talk between Matrix Stiffness and Protein Density: Independent Matrix Properties Regulate Spreading Dynamics of Myocytes

Cells, 2022
Cells actively sense differences in topology, matrix elasticity and protein composition of the extracellular microenvironment and adapt their function and morphology.
Judith Brock, Julia Erhardt, Stephan A. Eisler, Marcel Hörning   +3 more
doaj   +1 more source

Calsarcin-2 May Play a Compensatory Role in the Development of Obese Sarcopenia

Biomedicines, 2023
Although obese sarcopenia is a major public health problem with increasing prevalence worldwide, the factors that contribute to the development of obese sarcopenia are still obscure.
Yu-Cheng Liang, Kai-Pi Cheng, Hsin-Yu Kuo, Chung-Teng Wang, Hsuan-Wen Chou, Kuan-Lin Huang, Hung-Tsung Wu, Horng-Yih Ou   +7 more
doaj   +1 more source

Changes in Cardiomyocyte Cell Cycle and Hypertrophic Growth During Fetal to Adult in Mammals

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
The failure of adult cardiomyocytes to reproduce themselves to repair an injury results in the development of severe cardiac disability leading to death in many cases.
Sanford P. Bishop, Yang Zhou, Yuji Nakada, Jianyi Zhang   +3 more
doaj   +1 more source

Dexamethasone Treatment Preserves the Structure of Adult Cardiac Explants and Supports Their Long-Term Contractility In Vitro

International Journal of Translational Medicine, 2023
Normal contractile function of the myocardium is essential for optimal cardiovascular health. Evaluating drug effects on cardiomyocyte function at the cellular level is difficult for long-term studies.
Leonard M. Eisenberg, Keerat Kaur, John M. Castillo, John G. Edwards, Carol A. Eisenberg   +4 more
doaj   +1 more source

Cysteamine improves growth and the GH/IGF axis in gilthead sea bream (Sparus aurata): in vivo and in vitro approaches

Frontiers in Endocrinology, 2023
Aquaculture is the fastest-growing food production sector and nowadays provides more food than extractive fishing. Studies focused on the understanding of how teleost growth is regulated are essential to improve fish production.
Albert Sánchez-Moya, Sara Balbuena-Pecino, Emilio J. Vélez, Miquel Perelló-Amorós, Irene García-Meilán, Ramón Fontanillas, Josep Àlvar Calduch-Giner, Jaume Pérez-Sánchez, Jaume Fernández-Borràs, Josefina Blasco, Joaquin Gutiérrez   +10 more
doaj   +1 more source

Dynamic expression and differential requirement of the myocyte fusogen Myomixer during distinct myogenic episodes in the zebrafish [PDF]

Biology Open
Sunandan Dhar, Serena Thomas, Hui Li Yeo, Timothy E. Saunders, Sudipto Roy   +4 more
doaj   +2 more sources

Anatomical-MRI Correlations in Adults and Children with Arrhythmogenic Right Ventricular Cardiomyopathy

Diagnostics, 2021
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a rare disease in which the right ventricular myocardium is replaced by islands of fibro-adipose tissue. Therefore, ventricular re-entry circuits can occur, predisposing the patient to ventricular
Simona-Sorana Cainap, Ilana Kovalenko, Edoardo Bonamano, Niclas Crousen, Alexandru Tirpe, Andrei Cismaru, Daniela Iacob, Cecilia Lazea, Alina Negru, Gabriel Cismaru   +9 more
doaj   +1 more source