Simultaneous Isolation and Culture of Atrial Myocytes, Ventricular Myocytes, and Non-Myocytes from an Adult Mouse Heart [PDF]
Journal of Visualized Experiments, 2020 The isolation and culturing of cardiac myocytes from mice has been essential for furthering the understanding of cardiac physiology and pathophysiology. While isolating myocytes from neonatal mouse hearts is relatively straightforward, myocytes from the adult murine heart are preferred.
Erik A, Blackwood +4 more
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Time spent with cats is never wasted: Lessons learned from feline acromegalic cardiomyopathy, a naturally occurring animal model of the human disease [PDF]
, 2018 BackgroundIn humans, acromegaly due to a pituitary somatotrophic adenoma is a recognized cause of increased left ventricular (LV) mass. Acromegalic cardiomyopathy is incompletely understood, and represents a major cause of morbidity and mortality.
A Colao +80 more
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Gender differences in cardiac left ventricular mass and function: clinical and experimental observations [PDF]
, 2014 Background: The aim of this study was to evaluate gender-associated impact on left ventricular mass (LVM) and on left ventricular function (LVF) in humans and rats with aging. Methods: Myocyte area and collagen volume fraction (CVF) were studied in rats.
Aiello, Ernesto Alejandro +5 more
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Global intracoronary infusion of allogeneic cardiosphere-derived cells improves ventricular function and stimulates endogenous myocyte regeneration throughout the heart in swine with hibernating myocardium. [PDF]
PLoS ONE, 2014 Cardiosphere-derived cells (CDCs) improve ventricular function and reduce fibrotic volume when administered via an infarct-related artery using the "stop-flow" technique.
Gen Suzuki +6 more
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Micro-Managing Myocyte Mitosis [PDF]
Circulation Research, 2011 See related article, pages 670–679 In the adult mammalian heart, cardiac myocyte renewal is rare1,2 and insufficient to restore normal pump function after significant myocardial damage. Recent studies, however, suggest that zebrafish hearts3–5 and neonatal mouse hearts6 can regenerate after injury through enhanced cardiac myocyte proliferation.
Deqiang, Li, Jonathan A, Epstein
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Nucleus, 2019 The double membrane nuclear envelope (NE), which is contiguous with the ER, contains nuclear pore complexes (NPCs) – the channels for nucleocytoplasmic transport, and the nuclear lamina (NL) – a scaffold for NE and chromatin organization.
Li-Chun Cheng +8 more
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Effect of myocyte-fibroblast coupling on the onset of pathological dynamics in a model of ventricular tissue [PDF]
, 2017 Managing lethal cardiac arrhythmias is one of the biggest challenges in modern cardiology, and hence it is very important to understand the factors underlying such arrhythmias.
Panfilov, Alexander +2 more
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Intense myocyte formation from cardiac stem cells in human cardiac hypertrophy [PDF]
, 2003 It is generally believed that increase in adult contractile cardiac mass can be accomplished only by hypertrophy of existing myocytes. Documentation of myocardial regeneration in acute stress has challenged this dogma and led to the proposition that ...
Anversa P. +9 more
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Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018 Background Particulate matter (particles < 2.5 μm [PM2.5]) exposure during the in utero and postnatal developmental periods causes cardiac dysfunction during adulthood.
Vineeta Tanwar +9 more
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Cells, 2021 Atrial fibrillation is very common among the elderly and/or obese. While myocardial fibrosis is associated with atrial fibrillation, the exact mechanisms within atrial myocytes and surrounding non-myocytes are not fully understood.
Anirudh Krishnan +7 more
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