Results 11 to 20 of about 72,492 (253)

A mathematical model of the mouse ventricular myocyte contraction. [PDF]

open access: yesPLoS ONE, 2013
Mathematical models of cardiac function at the cellular level include three major components, such as electrical activity, Ca(2+) dynamics, and cellular shortening.
Paula D Mullins, Vladimir E Bondarenko
doaj   +3 more sources

Regulation of cardiac myocyte cell death.

open access: yes, 2003
Cardiac myocyte death, whether through necrotic or apoptotic mechanisms, is a contributing factor to many cardiac pathologies. Although necrosis and apoptosis are the widely accepted forms of cell death, they may utilize the same cell death machinery ...
Clerk, Angela   +5 more
core   +10 more sources

Elimination of Mutant mtDNA by an Optimized mpTALEN Restores Differentiation Capacities of Heteroplasmic MELAS-iPSCs

open access: yesMolecular Therapy: Methods & Clinical Development, 2021
Various mitochondrial diseases, including mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS), are associated with heteroplasmic mutations in mitochondrial DNA (mtDNA).
Naoki Yahata, Hiroko Boda, Ryuji Hata
doaj   +1 more source

Flecainide induces a sustained countercurrent dependent effect on RyR2 in permeabilized WT ventricular myocytes but not in intact cells

open access: yesFrontiers in Pharmacology, 2023
Background and purpose: While flecainide is now an accepted treatment for arrhythmias associated with catecholaminergic polymorphic ventricular tachycardia (CPVT), its mechanism of action remains controversial.
Emma J. Steer   +5 more
doaj   +1 more source

Uterine Endoplasmic Reticulum Stress and Its Unfolded Protein Response May Regulate Caspase 3 Activation in the Pregnant Mouse Uterus [PDF]

open access: yes, 2013
We have previously proposed that uterine caspase-3 may modulate uterine contractility in a gestationally regulated fashion. The objective of this study was to determine the mechanism by which uterine caspase-3 is activated and consequently controlled in ...
Subedi, Kalpana   +12 more
core   +2 more sources

KV4.3 Expression Modulates NaV1.5 Sodium Current

open access: yesFrontiers in Physiology, 2018
In cardiomyocytes, the voltage-gated transient outward potassium current (Ito) is responsible for the phase-1 repolarization of the action potential (AP).
Vincent Portero   +6 more
doaj   +1 more source

The myogenic kinome: protein kinases critical to mammalian skeletal myogenesis

open access: yesSkeletal Muscle, 2011
Myogenesis is a complex and tightly regulated process, the end result of which is the formation of a multinucleated myofibre with contractile capability.
Knight James DR, Kothary Rashmi
doaj   +1 more source

MicroRNAs in Sarcopenia: A Systematic Review

open access: yesFrontiers in Medicine, 2020
Sarcopenia, which is characterized by the loss of skeletal muscle, has been reported to contribute to development of physical disabilities, various illnesses, and increasing mortality. MicroRNAs (miRNAs) are small non-coding RNAs that inhibit translation
Katsunori Yanai   +9 more
doaj   +1 more source

The Efficacy of Flavonoid Antioxidant from Chocolate Bean Extract: Prevention of Myocyte Damage Caused by Reperfusion Injury in Predominantly Anaerobic Sports [PDF]

open access: yes, 2012
BACKGROUND: Use of predominantly anaerobic energy systems such as that seen in 800-meter athlete runners disrupts mitochondrial function as an energy source. Furthermore, it produces free radical substances and causes myocyte damage. Malondialdehyde (MDA)
HN Rasyid, R Prasetia, YD Ismiarto
core   +2 more sources

Active Movement of the Tunic in Halocynthia roretzi

open access: yesJournal of Biomechanical Science and Engineering, 2010
Halocynthia roretzi, a solitary ascidian, can swell and deflate its solid, leather-like tunic largely, but it is not clear whether the tunic deforms actively.
Yoko KATO
doaj   +1 more source

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