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Communication Signals Between Cardiac Fibroblasts and Cardiac Myocytes
Journal of Cardiovascular Pharmacology, 2011Interspersed between cardiac myocytes, cardiac fibroblasts serve mainly as a structural support during ventricular wall thickening from embryogenesis until adulthood. Cardiac fibroblasts, however, may also serve as a source of mitogens, extracellular matrix proteins, cytokines, and growth factors that could affect the phenotype of the cardiac myocyte ...
Filomena Ottaviano, K. Yee
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Mechanotransduction in Cardiac Myocytes
Annals of the New York Academy of Sciences, 2004Abstract: Cardiac myocytes react to diverse mechanical demands with a multitude of transient and long‐term responses to normalize the cellular mechanical environment. Several stretch‐activated signaling pathways have been identified, most prominently guanine nucleotide binding proteins (G‐proteins), mitogen‐activated protein kinases (MAPK), Janus ...
Jan, Lammerding +2 more
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Cardiac Myocyte Terminal Differentiation
Annals of the New York Academy of Sciences, 1995The exact mechanism of terminal differentiation in cardiac myocytes is currently unknown. Studies in the skeletal muscle system provided a model where muscle lineage termination gene directly interacts with Rb to produce and maintain the terminally differentiated state. This interaction provided the critical components for the lock in cell cycle arrest
S K, Tam +3 more
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Myocyte Growth and Cardiac Repair
Journal of Molecular and Cellular Cardiology, 2002Introduced several decades ago, the dogma persists that ventricular myocytes are terminally differentiated cells and cardiac repair by myocyte regeneration is completely inhibited shortly after birth. On the basis that cardiac myocytes are unable to divide in the adult heart, myocyte growth under physiologic and pathologic conditions is believed to be ...
Piero, Anversa +3 more
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Gene transfer in cardiac myocytes
Surgical Clinics of North America, 2004Congestive heart failure (CHF) represents an enormous clinical problem and remains a leading cause of death despite advances in treatment. New treatments significantly impact mortality and disease course; they do not cure the underlying pathology. Gene transfer, the ability to genetically reprogram the heart in relevant cardiovascular disease models ...
Babar B, Chaudhri +3 more
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Microtubules in Cardiac Myocytes
1988Publisher Summary This chapter describes the distribution of microtubules (MTs) in various physiopathological states and of their involvement in a broad spectrum of cellular processes. MTs, like actin filaments, are made up of globular protein subunits that can assemble and disassemble rapidly in the cell.
L, Rappaport, J L, Samuel
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Electrical stimulation of cardiac myocytes
Annals of Biomedical Engineering, 1995The influence of nonuniform cell shape and field orientation on the field stimulation thresholds of cardiac myocytes was studied both experimentally and computationally. The percent change in excitation threshold, which was studied with patch clamp technique, was found to be 182 +/- 83.1% (mean +/- SD) higher when the electric field (EF) was parallel ...
R, Ranjan, N V, Thakor
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Peroxynitrite-induced cardiac myocyte injury
Free Radical Biology and Medicine, 1996The effects of peroxynitrite (ONOO-) on cultured cardiac myocytes were examined by simultaneous measurements of intracellular Ca2+ ([Ca2+]i) and contractile function. On exposure to 0.2 mM ONOO-, [Ca2+]i increased to beyond the systolic level within 5 min with a concomitant decrease in spontaneous contraction of myocytes followed by complete arrest ...
H, Ishida +4 more
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Surface cables of cardiac myocytes
Journal of Molecular and Cellular Cardiology, 1980Abstract Heart muscle cells prepared by mechanical disaggregation were seen by transmission electron microscopy (TEM) to possess an intact glycocalyx. Scanning electron microscopy (SEM) studies of the surface of these cells revealed longitudinally oriented cables, 10 to 12 nm thick.
J, Orenstein, D, Hogan, S, Bloom
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