Results 191 to 200 of about 1,444,670 (278)

Shear Stress‐Stimulated Trafficking of Endothelial Piezo1 to Splenic Capsule Boosts Spleen Contraction and Exercise Endurance

Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.
The vasculo‐splenic axis during exercise: shear stress triggers the release of medium/large extracellular vesicles from vascular endothelial cells via activation of Piezo1, shuttling Piezo1 to the smooth muscle cells in the splenic capsule; the translocated Piezo1 within the splenic capsule acts as a downstream effector of the α1‐adrenergic receptor ...
Jing Lou, Mingzong Yang, Yang Hu, Xuyun Liu, Han Li, Zihang Feng, Yuxin Xi, Changyang Xing, Lijun Yuan, Jia Li, Shengpeng Wang, Feng Gao, Xing Zhang   +12 more
wiley   +1 more source

Complication management in hypertrophic cardiomyopathy. [PDF]

Heart Fail Rev
Höller V, Zwetsloot PP, Santner V, Schwegel N, Pötsch SL, Verheyen N, Michels M.   +6 more
europepmc   +1 more source

Iron and Other Metal Ions in Human Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
Iron, copper, zinc, and calcium orchestrate cellular function through distinct yet cooperative mechanisms: redox‐active iron and copper cycle between oxidation states to act as Fenton catalysts and electron carriers in oxidative phosphorylation (OXPHOS); redox‐inert zinc serves as a structural component of zinc‐finger proteins and a catalytic cofactor ...
Xiaofeng Dai, Jitian Li
wiley   +1 more source

AMPKγ2 Regulates Cardiac Hypertrophy and Arrhythmias via Interacting With Myosin. [PDF]

Circ Res
Ge Q, Saha K, Burch ML, Battista WH, Kc A, Homilius M, Victorio RA, Quan D, Huang HL, Hazel JM, Williams A, Pan E, Chinthalapudi K, Heissler SM, MacRae CA, Zhu W.   +15 more
europepmc   +1 more source

Cancer Cell Metastasis: From Molecular Mechanisms to Therapeutic Strategies

MedComm, Volume 7, Issue 10, October 2026.
The schematic representation of intrinsic and extrinsic influences of cancer cell metastasis. Genomic evolution of metastatic tumor cells (MTCs) promotes their metastatic phenotypes and reconstruct the primary tumor microenvironment. During MTCs migration along different routes (blood circulation, lymphatic vessels, and perineuronal spaces), the ...
Yupeng Zhao, Wenchao Xu, Yibo Wang, Haoran Huang, Yu Su, Li Zhou, Jianzhou Liu, Junchao Guo   +7 more
wiley   +1 more source

Radiotherapy‐Induced Side Effects: Epidemiology, Pathogenesis, Prevention and Treatments

MedComm, Volume 7, Issue 10, October 2026.
Radiotherapy for malignancies frequently injures the organs’ systems through oxidative stress, fibrosis, inflammation, and vascular damage. This review systematically maps the epidemiology, pathogenesis, and emerging therapies to propose a mechanism‑network‑targeted framework for integrated, personalized care in radiation oncology.
Xiaowen Ma, Xiaoxuan Zhang, Pujun Zhao, Jiaxin Yang, Zhihao Li, Xiaoyang Han, Yixuan Wang, Zhenzhen Cui, Nian Liu, Min Li   +9 more
wiley   +1 more source

Long-Term Follow-Up After Discontinuation of Mavacamten in Hypertrophic Obstructive CardiomyopathyNovel Teaching Points

CJC Open
Mengdi Yu, BMSc, Fang Wang, BMSc, Lutong Pu, MSc, Jie Wang, MD, Yucheng Chen, MD   +4 more
doaj   +1 more source

Authors' response: septal reduction therapy for obstructive hypertrophic cardiomyopathy. [PDF]

Eur Heart J Open
Schelldorfer A, Kutz A, Yakupoglu HY.
europepmc   +1 more source

From Single Forces to Integrated Signals: A Systematic Review of Endothelial Responses to Multifactorial Mechanics

Natural Sciences, Volume 6, Issue 4, October 2026.
Endothelial cells are concurrently exposed to shear stress (SS), substrate stiffness (ES), and cyclic strain (CS), stimuli that converge on vascular beds. Application of a single stimulus produces specific responses that do not necessarily match the combined application of these forces.
Patricio Morales‐Rosales, German A. Arenas, Felipe Muñoz, Duvan Henao, Bernardo J. Krause   +4 more
wiley   +1 more source

Immune Responses in Checkpoint Inhibitor-Associated Cardiovascular Immune-Related Adverse Events: JACC: CardioOncology State-of-the-Art Review. [PDF]

JACC CardioOncol
Reynolds KL, Villani AC, Drobni ZD, Neilan TG, Zhu H, Wagner NS, Balko JM, Fankhauser R, Moslehi JJ, Palaskas NL, Pauken KE, Siddiqui BA, Blum SM, Zlotoff DA.   +13 more
europepmc   +1 more source