Results 211 to 220 of about 1,444,670 (278)

Myostatin‐dependent detrusor remodelling mediates contractility impairment in diabetic rats’ bladder – a maximal elastance analysis

The Journal of Physiology, Volume 604, Issue 20, Page 8428-8449, 15 October 2026.
Abstract figure legend In the muscular layer of long‐standing diabetic bladders increased myostatin expression promotes tissue remodelling by reducing the muscle‐to‐collagen ratio, ultimately diminishing bladder contractility. Maximal elastance – defined as the slope of the end‐emission pressure–volume relationship (EPR), derived from the regression ...
Cheng‐Yuan Lai, Hui‐Hsuan Lau, Ming‐Chun Hsieh, Hsien‐Yu Peng, Dylan Chou, Tsung‐Hsien Su, Tzer‐Bin Lin   +6 more
wiley   +1 more source

Inhibition of Endothelial Phosphodiesterase 2A Attenuates Post-infarct Inflammation. [PDF]

JACC Basic Transl Sci
Wagde VV, Liu Z, Schlemper A, Bartolomaeus H, Potapenko T, Krebes L, Dabral S, Rizakou A, Sheta D, Monterisi S, Ramos G, Zernecke A, Zaccolo M, Kuhn M, Werner F.   +14 more
europepmc   +1 more source

Maternal protein restriction programs the ageing kidney: Proteomic signatures of early‐life origin renal and metabolic dysfunction

The Journal of Physiology, Volume 604, Issue 20, Page 8636-8661, 15 October 2026.
Abstract figure legend Maternal protein restriction (MPR) induced persistent renal histopathological alterations accompanied by elevated serum creatinine levels. Nephron‐segment proteomic analysis revealed region‐specific molecular dysregulation affecting Bowman's capsule (PARK7, oxidative stress sensor; MSN, cytoskeletal organization), the proximal ...
Marina Pereira Pires, Matheus Naia Fioretto, Marcel Rodrigues Ferreira, Isabelle Tenori Ribeiro, Luísa Annibal Barata, Flávia Alessandra Maciel, Lucas Sobrinho Lemos, Renato Mattos, Luiz Marcos Frediane Portela, Patrick Vieira de Souza, Luisa Correia Gomes, Gustavo Monezzi Cordeiro, Wellerson Rodrigo Scarano, Patrícia Aline Boer, Jose Antonio Rocha Gontijo, Luis Antonio Justulin   +15 more
wiley   +1 more source

Myofilament-level effects of aficamten increase diastolic chamber volumes and maintain cardiac output through preserved length-dependent force generation in healthy rat and canine myocardium. [PDF]

Basic Res Cardiol
Sárkány F, Priksz D, Juhász B, Fazekas LÁ, Németh N, Szentandrássy N, Horváth B, Kovács ZM, Borbély A, Ráduly AP, Tóth A, Fagyas M, Bódi B, Papp Z.   +13 more
europepmc   +1 more source

Adding Tat‐Beclin1 to an endurance training program promotes additive improvements in physical function in aged male mice

Physiological Reports, Volume 14, Issue 19, October 2026.
Abstract Autophagy is a hallmark of aging, but it has not been exclusively targeted to attenuate aging‐related physical dysfunction. Here, we combined Tat‐Beclin1 and endurance training to determine its effect on physical function domains in aged male mice.
Thuan Thien Tchen, Shakibur Rahman, Thaysa Ghiarone, Lynn A. Spruce, Hossein Fazelinia, Elizabeth M. Brown, Charalampos Papachristou, Sue C. Bodine, Vitor A. Lira, Kleiton A. S. Silva   +9 more
wiley   +1 more source

Research progress on the function of non-muscle myosin II during cell division. [PDF]

Front Cell Dev Biol
Ding J.
europepmc   +1 more source

Identification of Sodium/Myo‐Inositol Transporter 1 as a Major Determinant of Arterial Contractility

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
The tonicity‐responsive enhancer binding‐protein (TonEBP) and serum glucocorticoid kinase (SGK) sense a rise in extracellular hypertonicity resulting in an increase SMIT1 membrane abundance in vascular smooth muscle cells. SMIT1 associates with Kv7.4/5, Gβγ, and KCNE4, promoting hyperpolarization, reduced voltage‐gated calcium channel (VGCC) opening ...
Elizabeth A. Forrester, Skye Lau, Miguel Benitez‐Angeles, Christopher J. Garland, Vincenzo Barrese, Anthony P. Albert, Iain A. Greenwood   +6 more
wiley   +1 more source

Cardiac myosin-binding protein C in ST-elevation myocardial infarction. [PDF]

Eur Heart J Acute Cardiovasc Care
Rajakulasingam R, Alaour B, McGrath S, Couch LS, Sbeih Y, Khalique Z, Falaschetti E, Tindale A, Cantor EJ, Beattie CJ, Dalby M, Pennell DJ, Marber M, de Silva R.   +13 more
europepmc   +1 more source

Relaxin‐2: Shaping the Proteomic Landscape of Skeletal Muscle Physiology, Glucose Trafficking, and Mitochondrial Function in Rat

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
Cardioprotective hormone relaxin‐2 showed relevant effects on rat skeletal muscle by altering proteins linked to muscle function, regeneration, differentiation, mitochondrial function, glucose metabolism, and structural integrity and organization. Specifically, relaxin‐2 reduced the expression of 95 proteins, increased 32, and elicited unique proteins ...
Xocas Vázquez‐Abuín, Lucía Gómez‐Cibeira, Javier García‐Seara, Pablo de la Fuente‐López, Carlos Minguito‐Carazo, Susana B. Bravo, Manuel Otero‐Santiago, Oreste Gualillo, José Ramón González‐Juanatey, Francisca Lago, Sandra Feijóo‐Bandín, Alana Aragón‐Herrera   +11 more
wiley   +1 more source