Results 141 to 150 of about 19,651 (218)

Paradoxical Rise in Pulmonary Artery Pressure Following Successful Mavacamten Therapy for Obstructive Hypertrophic Cardiomyopathy: A Case Report

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT A paradoxical rise in pulmonary artery pressure on follow‐up echocardiography after successful mavacamten therapy for obstructive hypertrophic cardiomyopathy (oHCM) prompted right heart catheterization, which demonstrated combined pre‐ and post‐capillary pulmonary hypertension and guided the decision to continue mavacamten while withholding ...
Mengdian Zhang
wiley   +1 more source

ATOX1 alleviates radiation‐induced cardiac injury by modulating AMPK/NRF2 to inhibit myocardial oxidative stress and mitochondrial dysfunction

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
This study found that ATOX1 can alleviate radiation‐induced oxidative stress and mitochondrial damage, maintain mitochondrial function, and reduce oxidative stress by activating the AMPK/NRF2 signaling pathway, ultimately exerting a cardioprotective effect.
Wen Deng, Li Su
wiley   +1 more source

Phosphoproteomics Preliminarily Revealed the Differential Phosphorylation Sites and Their Functional Significance in the Longissimus Dorsi Muscle of Kazakh and Xinjiang Brown Cattle

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
The phosphorylated protein profiles of the longissimus dorsi muscle tissues of Xinjiang brown cattle and Kazakh cattle were analyzed. RAB12 was a differentially expressed phosphorylated protein. After knockdown of RAB12, the immunofluorescence intensity of MYHC significantly increased, promoting myoblast differentiation.
Ailifeire Wumaier, Zhen Ma, Wenzhong Chen, Meng Liu, Sumei Chen, Sihan Wang, Wenjing Wang, Xiao Wang, Xiangmin Yan, Lei Chen   +9 more
wiley   +1 more source

Mavacamten Cardiac Myosin Inhibitor: Clinical Applications and Future Perspectives [PDF]

Mahmoud M. Ramadan, Raghad A Al-Najjar, Rokia S Abady, Hala A Obaid, Yasmeen A Mostafa, Mohammad T Al-Obeid, Mohammed Elmahal   +6 more
openalex   +1 more source

Biomaterial Physical Cues as Gene Regulators for Cellular Agriculture

Advanced Genetics, Volume 7, Issue 2, June 2026.
This review elucidates how biomaterial physical cues—ranging from matrix stiffness to remote electromagnetic fields—serve as extrinsic regulators of gene expression in cellular agriculture. By identifying central mechanotransduction pathways that bridge physical inputs to genetic remodeling, the authors propose the “Material Genome” concept: a ...
Jianuo Liu, Ye Liu
wiley   +1 more source

CYP450 activity, drug interactions, and genetic polymorphisms: clinical relevance for the new selective cardiac myosin inhibitors [PDF]

Milind Y. Desai, Véronique Michaud, David Thacker, Matthew L. Arwood, Pamela Dow, Matthew W. Martinez, Michele Michels, Anjali Owens, Jacques Turgeon   +8 more
openalex   +1 more source

Perceived barriers to physical activity in obstructive hypertrophic cardiomyopathy patients: effect of cardiac myosin inhibitors

H Seghers, W Hens, A B Gevaert, A Vorlat, S Naessens, E M Van Craenenbroeck   +5 more
openalex   +1 more source

Dysregulation of Non‐Muscle Myosin IIA Assembly and Phosphorylation in S100A4 Null Mouse Lens

Journal of Cellular Physiology, Volume 241, Issue 6, June 2026.
This study identifies S100A4 as a critical regulator of NMIIA assembly, phosphorylation, and actin cytoskeletal organization in the ocular lens. Loss of S100A4 disrupts lens fiber cell architecture and impairs lens transparency, revealing a previously unrecognized role for S100A4 in maintaining lens homeostasis and structural integrity.
Rupalatha Maddala, Levi K. Lankford, Nikolai P. Skiba, Ponugoti V. Rao   +3 more
wiley   +1 more source

Deubiquitinase YOD1 Inhibition Suppresses DEX‐ and Denervation‐Induced Muscle Atrophy Through MAFbx Destabilization

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
ABSTRACT Backgrounds Muscle atrophy, characterized by progressive loss of muscle mass and function, is driven by muscle‐specific E3 ligases MAFbx and MuRF1. While transcriptional regulation of E3 ligases is documented, the mechanism of their regulation by the ubiquitin–proteasome system remains unclear. This study aims to identify a deubiquitinase (DUB)
Jongbeom Chae, Seon Min Woo, Seung Un Seo, Simmyung Yook, Hyo Je Cho, Jung Yeol Lee, Kyoung jin Min, Junhyeon Park, Dongryeol Ryu, Taeg Kyu Kwon   +9 more
wiley   +1 more source

The clinical utility of cardiac myosin inhibitors for the management of hypertrophic cardiomyopathy: a scoping review. [PDF]

Heart Fail Rev
Othman L, Koskina L, Huerta N, Rao SJ.
europepmc   +1 more source