Results 71 to 80 of about 6,808 (263)

Co‐Opting MBNL‐Dependent Alternative Splicing Cassette Exons to Control Gene Therapy in Myotonic Dystrophy

Annals of Neurology, EarlyView.
Objective Myotonic dystrophy type 1 (DM1) is a highly variable, multisystemic genetic disorder caused by a CTG repeat expansion in the 3′ untranslated region of DMPK. Toxicity is exerted by repeat‐containing DMPK transcripts that sequester muscleblind‐like (MBNL) proteins and lead to deleterious yet predictable changes in alternative splicing.
Samuel T. Carrell, Ellie M. Carrell, Ryan Giovenco, Beverly L. Davidson   +3 more
wiley   +1 more source

Three-dimensional stochastic model of actin–myosin binding in the sarcomere lattice [PDF]

, 2016
The effect of molecule tethering in three-dimensional (3-D) space on bimolecular binding kinetics is rarely addressed and only occasionally incorporated into models of cell motility.
Bathe, Bathe, Boban Stojanovic, Bordas, Burgoyne, Chase, Daniel, Decostre, Djordje Nedic, Duke, Edman, Evans, Eyring, Ford, Glasstone, Higuchi, Hill, Hill, Hunt, Huxley, Huxley, Huxley, Huxley, Huxley, Katz, Kojic, Kojima, Kojić, Kramers, Linari, Linari, Lombardi, Luther, Luther, Matsubara, McMahon, Michael A. Geeves, Mijailovich, Mijailovich, Mijailovich, Millman, Mobley, Oliver Kayser-Herold, Papoulis, Pate, Piazzesi, Piazzesi, Prodanovic, Smith, Smith, Smith, Smith, Squire, Srboljub M. Mijailovich, Steffen, Tanner, Tanner, Tanner, Thomas C. Irving, Vilfan, Wakabayashi, Williams, Williams, Wood, Zahalak   +64 more
core   +2 more sources

Bioprinted Excitable Tissues with Multistimulation Systems for Promoting Function and Maturation

Advanced NanoBiomed Research, EarlyView.
This review provides an overview of stimulation strategies used to enhance the functional maturation of bioprinted excitable tissues. It addresses key limitations in physiological performance of bioprinted excitable tissues, outlines major stimulation modalities—including electrical, mechanical, optical, magnetic, ultrasound, and hybrid—and examines ...
Uijung Yong, Jinseon Park, Jinah Jang
wiley   +1 more source

Combined mutation screening of NKX2-5, GATA4, and TBX5 in congenital heart disease: multiple heterozygosity and novel mutations [PDF]

, 2011
Background: Variants of several genes encoding transcription modulators, signal transduction, and structural proteins are known to cause Mendelian congenital heart disease (CHD).
Agulnik, Ami Ketley, Arceci, Azpiazu, Basson, Bodmer, Budde, Burn, Butler, Chen, Ching, Christopher Thornborough, Coll, Dentice, Diane Fatkin, Durocher, Edwin P. Kirk, Elliott, Fan, Ferencz, Frances A. Bu'Lock, Garg, Granados-Riveron, Harvey, Hiroi, J. David Brook, Jacqueline Eason, Javier T. Granados-Riveron, Kennedy, Kerry Setchfield, Kim, Kneller, Komuro, Li, Lints, Liu, Manolio, Mark Pope, Matsson, McDermott, Michael P. Feneley, Nemer, Nora, Pannu, Pehlivan, Pierpont, Rajagopal, Reamon-Buettner, Rey, Richard P. Harvey, Schluterman, Schott, Stanley, Stirnimann, Tang, Tomita-Mitchell, Uhler, Watada, Winston, Yang, Zhang, Zhu   +61 more
core   +2 more sources

Force stimulation promotes nerve regeneration by restoring cellular energy

BMEMat, EarlyView.
Mechanical stimulation can help nerves regenerate in various ways. We developed two devices (a piezo‐motor‐driven stretching device and a SAW‐based actuator) to apply mechanical stimulation to sciatic nerve and DRG neurons. Our study shows that appropriate mechanical force stimulation can promote regeneration by restoring the energy supply to the ...
Zhe Wang, Chen Cai, Hetao Xie, Yupeng Yang, Lei Li, Nik Ahmad Nizam Nik Malek, Wan Hairul Anuar Kamaruddin, Meiwan Chen, Yuanhua Sang, Bing Ji, Zenan Wang   +10 more
wiley   +1 more source

Preferential Myosin Heavy Chain Isoform B Expression May Contribute to the Faster Velocity of Contraction in Veins versus Arteries [PDF]

, 2007
Smooth muscle myosin heavy chains occur in 2 isoforms, SMA (slow) and SMB (fast). We hypothesized that the SMB isoform is predominant in the faster-contracting rat vena cava compared to thoracic aorta.
Eddinger, Thomas, Fink, Gregory D, Kayal, Anas, Rondelli, Catherine M, Rovner, Arthur S, Szasz, Irina T, Thakali, Keshari, Watson, Ralph E, Watts, Stephanie W   +8 more
core   +1 more source

Protein multi-scale organization through graph partitioning and robustness analysis: Application to the myosin-myosin light chain interaction

, 2011
Despite the recognized importance of the multi-scale spatio-temporal organization of proteins, most computational tools can only access a limited spectrum of time and spatial scales, thereby ignoring the effects on protein behavior of the intricate ...
A Delmotte, Aynaud T, Blondel V D, Delano W L, Delmotte A, E W Tate, Hettmann C, Lambiotte R Delvenne J C Barahona M, M Barahona, Meliga S, Meliga S Yaliraki S N Barahona M, Newman M E J, S N Yaliraki, Schiaffino S   +13 more
core   +1 more source

Pig cardiac myosin isoenzymes.

European journal of cell biology, 1980
Pig heart myosins isolated from the free wall of the right ventricle and the free wall of the left ventricle were compared with respect to structural and enzymatic properties. The following parameters were studied (1) activation of myosin ATase by Ca2+ and K+j(2) molecular weight of the heavy and light chains of myosins as determined by electrophoretic
X, Grandier-Vazeille, D, Tetaert, H F, Hildebrand, G, Biserte   +3 more
openaire   +1 more source

Titin Is Present in the Elastic Tethers That Connect Separating Anaphase Chromosomes in Crane‐Fly Spermatocytes

Cytoskeleton, EarlyView.
ABSTRACT Elastic tethers connect telomeres of separating chromosomes in anaphase of animal cells. Immunofluorescence staining of titin in crane‐fly spermatocytes, using 4 different antibodies, shows that the giant elastic protein titin seems to be a component of mitotic tethers: titin “strands” extend between separating chromosomes, connecting their ...
Demetra Economopoulos, Maral Janan, Martina Krüger, Aavo‐Valdur Mikelsaar, Arthur Forer, Rose Sheykhani   +5 more
wiley   +1 more source

Experiment K-6-10. Effects of zero gravity on myofibril protein content and isomyosin distribution in rodent skeletal muscle [PDF]

The purpose of this experiment was to investigate the effects of 12 days of zero gravity (0G) exposure (Cosmos 1887 Biosputnik) on the enzymatic properties, protein content, and isomyosin distribution of the myofibril fraction of the slow-twitch vastus ...
Baldwin, K., Herrick, R., Oganov, V.
core   +1 more source