Results 51 to 60 of about 4,202 (274)

Multi‐Omics Insights Into the Mechanisms of Early Muscle Fiber Difference and Transformation Between Lean‐Type and Chinese Indigenous Pigs

Advanced Science, EarlyView.
Multi‐omics analyses uncover breed‐specific cis‐regulatory landscapes and higher‐order chromatin architectural differences that underlie early postnatal muscle fiber divergence in pigs. A super‐enhancer upstream of PPP3CB recruits MEF2C to activate PPP3CB transcription, while the PPP3CB–MEF2C positive feedback loop promotes oxidative muscle fiber ...
Shuailong Zheng, Hainan Wu, Min Liu, Kunpeng Wu, Shuntao Huang, Zulfiqar Ahmed, Lenox Pius, Mengjin Zhu, Dequan Xu   +8 more
wiley   +1 more source

Lactation is Associated with Accelerated Postpartum Pelvic Floor Muscle Recovery in a Pregnant Simulated Birth Injury Model

Advanced Science, EarlyView.
ABSTRACT Healthy pelvic floor muscles (PFMs) are essential for proper pelvic floor function. The biggest risk factor for PFM dysfunction is injury sustained during vaginal childbirth, yet the factors that facilitate or impair PFM recovery from birth injury remain unknown.
Bianca L. Peña, Khushi M. Diwakar, Hillary K. Tran, Selena Cao, Celeste E. Lintz, Laila N. Hayes, Marianna Alperin, Karen L. Christman   +7 more
wiley   +1 more source

Cardiac Myosin-Binding Protein-C Phosphorylation and Cardiac Function [PDF]

Circulation Research, 2005
The role of cardiac myosin binding protein-C (cMyBP-C) phosphorylation in cardiac physiology or pathophysiology is unclear. To investigate the status of cMyBP-C phosphorylation in vivo, we determined its phosphorylation state in stressed and unstressed mouse hearts.
Sakthivel, Sadayappan, James, Gulick, Hanna, Osinska, Lisa A, Martin, Harvey S, Hahn, Gerald W, Dorn, Raisa, Klevitsky, Christine E, Seidman, Jonathan G, Seidman, Jeffrey, Robbins   +9 more
openaire   +2 more sources

The E3 Ligase RNF115 Aggravates Pathological Cardiac Hypertrophy via Ubiquitin‐Mediated Degradation of SPTBN1

Advanced Science, EarlyView.
In response to hypertrophic stimuli, increased c‑JUN phosphorylation upregulates RNF115, leading to SPTBN1 ubiquitination and degradation. which promotes F‑actin depolymerization and YAP activation, driving cardiac hypertrophy. The RNF115 inhibitor DTD effectively suppresses SPTBN1 ubiquitination and cardiac hypertrophy.
Yan Zu, Shiqing Chen, Ji Chen, Liuliu Ruan, Bowen Li, Weijian Chu, Shichen Huang, Dian Yu, Jing Tian, Yuhan Zhao, Yi Han, Xin Tang, Yong Ji   +12 more
wiley   +1 more source

Cardiac myosin-binding protein C (MYBPC3) in cardiac pathophysiology [PDF]

Gene, 2015
More than 350 individual MYPBC3 mutations have been identified in patients with inherited hypertrophic cardiomyopathy (HCM), thus representing 40–50% of all HCM mutations, making it the most frequently mutated gene in HCM. HCM is considered a disease of the sarcomere and is characterized by left ventricular hypertrophy, myocyte disarray and diastolic ...
Lucie, Carrier, Giulia, Mearini, Konstantina, Stathopoulou, Friederike, Cuello   +3 more
openaire   +2 more sources

Chrysin alleviates pressure overload–induced myocardial remodeling through regulating the PI3K/AKT/NRF2 pathway–mediated oxidative stress response

Animal Models and Experimental Medicine, EarlyView.
In this study, we primarily simulated pathological myocardial remodeling induced by transverse aortic constriction surgery and found significant cardiac hypertrophy and fibrosis, characterized by deteriorated cardiac function. Oxidative stress response is considered as a pivotal pathological process, which contributes to inflammation and apoptosis of ...
Yijia Wang, Xing Feng, Shuhui Zhao, Yuchong Fu, Ao Zhang, Xiaofeng Shen, Bowen Yu, Yihao Wang, Jiahui Lin, Bing Zhang, Weiping Ji, Lianpin Wu, Xiaoling Guo   +12 more
wiley   +1 more source

ATP-induced reconfiguration of the micro-viscoelasticity of cardiac and skeletal myosin solutions. [PDF]

Appl Phys Lett
We study the high-frequency micro-mechanical response of suspensions composed by cardiac and skeletal muscle myosin by optical trapping interferometry. We observe that in low ionic strength solutions upon the addition of magnesium adenosine triphosphate (
Domínguez-García P, Pinto JR, Akrap A, Jeney S.   +3 more
europepmc   +2 more sources

Cardiac myosin binding protein C phosphorylation in cardiac disease [PDF]

Journal of Muscle Research and Cell Motility, 2011
Perturbations in sarcomeric function may in part underlie systolic and diastolic dysfunction of the failing heart. Sarcomeric dysfunction has been ascribed to changes in phosphorylation status of sarcomeric proteins caused by an altered balance between intracellular kinases and phosphatases during the development of cardiac disease.
Kuster DWD, Cholid Bawazeer A, Zaremba R, Goebel M, Boontje NM, van der Velden J.   +5 more
openaire   +4 more sources

The slow skeletal muscle isoform of myosin shows kinetic features common to smooth and non-muscle myosins

, 2007
Fast and slow mammalian muscle myosins differ in the heavy chain sequences (MHC-2, MHC-1) and muscles expressing the two isoforms contract at markedly different velocities.
Adamek, Nancy, Geeves, Michael A., Iorga, Bogdan   +2 more
core   +1 more source

Alternative Exon 9-Encoded Relay Domains Affect More than One Communication Pathway in the Drosophila Myosin Head [PDF]

, 2009
We investigated the biochemical and biophysical properties of one of the four alternative regions within the Drosophila myosin catalytic domain: the relay domain encoded by exon 9.
Girish C. Melkani, Bernstein, Sanford I., Corey M. Dambacher, Geeves, M., Melkani, Girish C., Knowles, Aileen F., Geeves, Michael A., Marieke J. Bloemink, Aileen F. Knowles, Melanki, G., Bloemink, Marieke J., Bloemink, M., Bernstein, S., Sanford I. Bernstein, Dambacher, C., Knowles, A., Dambacher, Corey M., Michael A. Geeves   +17 more
core   +1 more source