Results 71 to 80 of about 6,676 (255)

Harmonic Force Spectroscopy measures load-dependent kinetics of individual human β-cardiac myosin molecules [PDF]

, 2015
International audienceMolecular motors are responsible for numerous cellular processes from cargo transport to heart contraction. Their interactions with other cellular components are often transient and exhibit kinetics that depend on load.
Flyvbjerg, Henrik, Mortensen, Kim, Nag, Suman, Ruppel, Katleen, Spudich, James A., Sung, Jongmin, Sutton, Shirley, Vestergaard, Christian L.   +7 more
core   +4 more sources

Fhod3 in zebrafish supports myofibril stability during growth of embryonic skeletal muscle

Developmental Dynamics, EarlyView.
Abstract Background Actin filament organization in cardiomyocytes critically depends on the formin Fhod3, but a role for Fhod3 in skeletal muscle development has not yet been described. Results We demonstrate here that in zebrafish mutated for one of two fhod3 paralog genes, fhod3a, skeletal muscle of the trunk appears normal through 2 days post ...
Aubrie Russell, Tracy Eng, Jeffrey D. Amack, David Pruyne   +3 more
wiley   +1 more source

Combined mutation screening of NKX2-5, GATA4, and TBX5 in congenital heart disease: multiple heterozygosity and novel mutations [PDF]

, 2011
Background: Variants of several genes encoding transcription modulators, signal transduction, and structural proteins are known to cause Mendelian congenital heart disease (CHD).
Agulnik, Ami Ketley, Arceci, Azpiazu, Basson, Bodmer, Budde, Burn, Butler, Chen, Ching, Christopher Thornborough, Coll, Dentice, Diane Fatkin, Durocher, Edwin P. Kirk, Elliott, Fan, Ferencz, Frances A. Bu'Lock, Garg, Granados-Riveron, Harvey, Hiroi, J. David Brook, Jacqueline Eason, Javier T. Granados-Riveron, Kennedy, Kerry Setchfield, Kim, Kneller, Komuro, Li, Lints, Liu, Manolio, Mark Pope, Matsson, McDermott, Michael P. Feneley, Nemer, Nora, Pannu, Pehlivan, Pierpont, Rajagopal, Reamon-Buettner, Rey, Richard P. Harvey, Schluterman, Schott, Stanley, Stirnimann, Tang, Tomita-Mitchell, Uhler, Watada, Winston, Yang, Zhang, Zhu   +61 more
core   +4 more sources

Molecular weight studies of canine cardiac myosins [PDF]

FEBS Letters, 1974
Only recently were conditions developed for determining accurately the molecular weight of myosin [ 1,2] . Conditions selective for obtaining myosin in a monomeric form were used such as, analyses of myosin at a low protein concentration ( 0.3 M KCl) [l-3] .
Smith, Alan, Mason, Dean T., Wikman-Coffelt, Joan   +2 more
openaire   +2 more sources

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source

Induction of Myocarditis and Valvuluitis in Lewis Rats by Different Epitopes of Cardiac Myosin and its Implications in Rheumatic Carditis [PDF]

, 2002
Immune responses against cardiac myosin and group A streptococcal M protein have been implicated in the pathogenesis of rheumatic heart disease.
Cunningham, Madeleine W., Factor, Stephen M., Galvin, Jeffrey E., Hemric, Mark E., Konsanke, Stanley D., Quinn, Anthony   +5 more
core  

Cardiac remodelling in the era of the recommended four pillars heart failure medical therapy

ESC Heart Failure, Volume 12, Issue 2, Page 1029-1044, April 2025.
Abstract Cardiac remodelling is a key determinant of worse cardiovascular outcome in patients with heart failure (HF) and reduced ejection fraction (HFrEF). It affects both the left ventricle (LV) structure and function as well as the left atrium (LA) and the right ventricle (RV).
Giada Colombo, Tor Biering‐Sorensen, Joao P. Ferreira, Carlo Mario Lombardi, Andrea Bonelli, Andrea Garascia, Marco Metra, Riccardo M. Inciardi   +7 more
wiley   +1 more source

UCS protein function is partially restored in the Saccharomyces cerevisiae she4 mutant with expression of the human UNC45-GC, but not UNC45-SM [PDF]

, 2017
A dedicated UNC45, Cro1, She4 (UCS) domain-containing protein assists in the Hsp90-mediated folding of the myosin head. Only weak sequence conservation exists between the single UCS protein of simple eukaryotes (She4 in budding yeast) and the two UCS ...
A Chadli, AH Hutagalung, AL Goldstein, B Panaretou, B Wendland, C Etard, CF Lee, E Smythe, H Shi, H Toi, HV Goodson, JM Barral, JM Barral, Joseph A. Brightmore, KC Wong, L Gazda, M Bazzaro, M Lord, M Lord, M Mishra, M Taipale, MG Price, ML Landsverk, Peter W. Piper, RK Niedenthal, RM Long, S Gómez Escalante, S Wesche, SA Comyn, SH Millson, Stefan H. Millson, Susana Gómez Escalante, T Kachur, W Ao, W Ni   +34 more
core   +3 more sources

The effects of sodium–glucose cotransporter 2 inhibitors on the ‘forgotten’ right ventricle

ESC Heart Failure, Volume 12, Issue 2, Page 1045-1058, April 2025.
Abstract With the progress in diagnosis, treatment and imaging techniques, there is a growing recognition that impaired right ventricular (RV) function profoundly affects the prognosis of patients with heart failure (HF), irrespective of their left ventricular ejection fraction (LVEF).
Liangzhen Qu, Xueting Duan, Han Chen
wiley   +1 more source

Why are some muscles striated? A structural mechanism that amplifies shortening velocity

Advances in Physiology Education
Physiology textbooks consistently describe how the repeating sarcomeric organization of vertebrate skeletal and cardiac muscle generates a striated appearance.
Scott Medler
doaj   +1 more source