Results 61 to 70 of about 6,676 (255)

Myosin isoenzymes in human hypertrophic hearts. Shift in atrial myosin heavy chains and in ventricular myosin light chains [PDF]

, 2017
The myosin light chain complement and proteolytic peptide patterns of myosin heavy chains were studied by two-dimensional and one-dimensional electrophoretic techniques respectively, in a total of 57 samples from ventricular and atrial tissues of normal ...
Hirzel, H. O., Schaub, M. C., Srihari, T., Tuchschmid, C. R.   +3 more
core  

A Combination of Diffusion and Active Translocation Localizes Myosin 10 to the Filopodial Tip [PDF]

, 2016
Myosin 10 is an actin-based molecular motor that localizes to the tips of filopodia in mammalian cells. To understand how it is targeted to this distinct region of the cell we have used total internal reflection fluorescence microscopy (TIRFM) to study ...
Baboolal, Berg, Berg, Berg, Billington, Bohil, Cheney, Cramer, Creed, Gunning, Hartman, Hern, Hirano, Kee, Kerber, Knight, Lister, Lu, Lu, Makowska, Mashanov, Mashanov, Mashanov, Mashanov, Nagy, Odronitz, Park, Peckham, Plantard, Ricca, Sanders, Schneider, Sellers, Sun, Svitkina, Tacon, Takagi, Tokuo, Tokuo, Umeki, Umeki, Vavra, Watanabe, Weber, Wei, Wolny, Yang, Zhang, Zhu   +48 more
core   +1 more source

A comprehensive proteome and phosphoproteome atlas across nine organs of the Chinese hamster

Animal Models and Experimental Medicine, EarlyView.
This study presents the first comprehensive proteome and phosphoproteome atlas of the Chinese hamster across nine organs (heart, liver, lung, kidney, spleen, cerebral cortex, skeletal muscle, stomach, and testis or ovary). A total of 14 219 proteins were identified in the proteome, with 11 828 phosphorylated proteins and 47 122 phosphorylation sites ...
Luyao Zhang, Tao Ding, Wanjun Peng, Jie Kong, Xiaoyue Tang, Jiyu Xu, Qiaochu Wang, Zhiyi Zhang, Chunmei Shi, Yizhuo Tian, Huilan Yang, Yehong Yang, Yue Wu, Xiaoyan Liu, Jiangfeng Liu, Juntao Yang   +15 more
wiley   +1 more source

The Efficacy of Administering Fruit-Derived Polyphenols to Improve Health Biomarkers, Exercise Performance and Related Physiological Responses [PDF]

, 2019
open access articlePolyphenols are secondary metabolites involved in a myriad of critical processes in plants. Over recent decades, special attention has been paid to the anti-oxidative role of fruit-derived polyphenols in the human diet, with evidence ...
Bailey, Stephen, Da Boit, Mariasole, Higgins, Matthew, Kashi, Daniel, Shabir, Akbar   +4 more
core   +1 more source

Force stimulation promotes nerve regeneration by restoring cellular energy

BMEMat, EarlyView.
Mechanical stimulation can help nerves regenerate in various ways. We developed two devices (a piezo‐motor‐driven stretching device and a SAW‐based actuator) to apply mechanical stimulation to sciatic nerve and DRG neurons. Our study shows that appropriate mechanical force stimulation can promote regeneration by restoring the energy supply to the ...
Zhe Wang, Chen Cai, Hetao Xie, Yupeng Yang, Lei Li, Nik Ahmad Nizam Nik Malek, Wan Hairul Anuar Kamaruddin, Meiwan Chen, Yuanhua Sang, Bing Ji, Zenan Wang   +10 more
wiley   +1 more source

Unraveling the evolutionary origin of the complex Nuclear Receptor Element (cNRE), a cis-regulatory module required for preferential expression in the atrial chamber

Communications Biology
Cardiac function requires appropriate proteins in each chamber. Atria requires slow myosin to act as reservoirs, while ventricles demand fast myosin for swift pumping.
Luana Nunes Santos, Ângela Maria Sousa Costa, Martin Nikolov, João E. Carvalho, Allysson Coelho Sampaio, Frank E. Stockdale, Gang Feng Wang, Hozana Andrade Castillo, Mariana Bortoletto Grizante, Stefanie Dudczig, Michelle Vasconcelos, Nadia Rosenthal, Patricia Regina Jusuf, Hieu T. Nim, Paulo de Oliveira, Tatiana Guimarães de Freitas Matos, William Nikovits, Izabella Luisa Tambones, Ana Carolina Migliorini Figueira, Michael Schubert, Mirana Ramialison, José Xavier-Neto   +21 more
doaj   +1 more source

Calcium gets myosin VI ready for work. [PDF]

, 2016
Funded by the BBSRC.This is the author accepted manuscript. The final version is available from the National Academy of Sciences via http://dx.doi.org/10.1073/pnas ...
Buss, Folma, Kendrick-Jones, John, Masters, Thomas A   +2 more
core   +2 more sources

Titin Is Present in the Elastic Tethers That Connect Separating Anaphase Chromosomes in Crane‐Fly Spermatocytes

Cytoskeleton, EarlyView.
ABSTRACT Elastic tethers connect telomeres of separating chromosomes in anaphase of animal cells. Immunofluorescence staining of titin in crane‐fly spermatocytes, using 4 different antibodies, shows that the giant elastic protein titin seems to be a component of mitotic tethers: titin “strands” extend between separating chromosomes, connecting their ...
Demetra Economopoulos, Maral Janan, Martina Krüger, Aavo‐Valdur Mikelsaar, Arthur Forer, Rose Sheykhani   +5 more
wiley   +1 more source

Quantitative proteomics and systems analysis of cultured H9C2 cardiomyoblasts during differentiation over time supports a ‘function follows form’ model of differentiation [PDF]

, 2018
The rat cardiomyoblast cell line H9C2 has emerged as a valuable tool for studying cardiac development, mechanisms of disease and toxicology. We present here a rigorous proteomic analysis that monitored the changes in protein expression during ...
Clarke, Kylie, Dittrich, Anna, Gevaert, Kris, Huber, Heinrich J, Impens, Francis, Kankeu, Cynthia, Passante, Egle, Roderick, H Llewelyn, Van Haver, Delphi   +8 more
core   +2 more sources

Isoform Specificity of a Compound Targeting Actin Filaments Containing Tropomyosin Tpm1.8/1.9

Cytoskeleton, EarlyView.
ABSTRACT The unbranched actin filaments in mammalian cells are usually composed of co‐polymers of a specific tropomyosin isoform with actin. Genetic manipulation has revealed that the tropomyosins largely define the functional properties of actin filaments in an isoform‐specific, non‐redundant manner.
Jeff Hook, Edna C. Hardeman, Peter W. Gunning   +2 more
wiley   +1 more source