Results 41 to 50 of about 6,676 (255)

MRF4 negatively regulates adult skeletal muscle growth by repressing MEF2 activity [PDF]

, 2016
The myogenic regulatory factor MRF4 is highly expressed in adult skeletal muscle but its function is unknown. Here we show that Mrf4 knockdown in adult muscle induces hypertrophy and prevents denervation-induced atrophy.
Abraham, Reimar, Agatea, Lisa, Akimoto, Takayuki, Bicciato, Silvio, Blaauw, Bert, Calabria, Elisa, Carvajal, Jaime J., Ciciliot, Stefano, Dyar, Kenneth A., Forcato, Mattia, Moretti, Irene, Murgia, Marta, Pierre, Philippe, Rigby, Peter W. J., Schiaffino, Stefano, Uhlenhaut, N. Henriette   +15 more
core   +5 more sources

Functional Characterization of Cardiac Myosin Isoforms.

The Japanese Journal of Physiology, 1998
In this brief review, we have discussed the functional significance of cardiac myosin isoform redistribution. The development of in vitro motility assay techniques has greatly aided the research in this field. The next important step would be the integration of data at molecular or cellular level to account for the pathophysiology of animal or human ...
S, Sugiura, H, Yamashita
openaire   +3 more sources

UNC-45a promotes myosin folding and stress fiber assembly [PDF]

, 2017
Contractile actomyosin bundles, stress fibers, are crucial for adhesion, morphogenesis, and mechanosensing in nonmuscle cells. However, the mechanisms by which nonmuscle myosin II (NM-II) is recruited to those structures and assembled into functional ...
Aidan M. Fenix, Anderson, Baird, Barral, Barral, Bazzaro, Beach, Berg, Berg, Billington, Bird, Blanchoin, Breiman, Bujalowski, Burgess, Burnette, Burnette, Case, Chadli, Chadli, Chen, Choi, Chow, Clarke, Comyn, Craig, Dylan T. Burnette, Epping, Epstein, Etard, Etard, Fenix, Gaiser, Gazda, Geach, Gibala, Giuseppe Balistreri, Guo, Gustafsson, Henderson, Horvath, Hotulainen, Hu, Iizuka, Jaakko I. Lehtimäki, Jorrisch, Kamentsky, Lam, Landsverk, Lassi Paavolainen, Lee, Lee, Lee, Liu, Liu, Markku Varjosalo, McNeil, Mehta, Melkani, Melkani, Myhre, Nambiar, Ni, Niederman, Odronitz, Paulsen, Pekka Lappalainen, Price, Ran, Raucher, Roux, Sandquist, Schneider, Schulze, Shih, Shutova, Shutova, Skau, Srikakulam, Thoresen, Toi, Tojkander, Tojkander, Tojkander, Tommi M. Kotila, Umemoto, Venolia, Vicente-Manzanares, Vicente-Manzanares, Wei, Wells, Wohlgemuth, Wolfenson, Ye   +93 more
core   +1 more source

Mammalian myosin I alpha, I beta, and I gamma: new widely expressed genes of the myosin I family. [PDF]

, 1993
A polymerase chain reaction strategy was devised to identify new members of the mammalian myosin I family of actin-based motors. Using cellular RNA from mouse granular neurons and PC12 cells, we have cloned and sequenced three 1.2-kb polymerase chain ...
Greene, LA, Joyce, MP, Sherr, EH
core  

Mechanical and Electrical Phenotype of hiPSC‐Cardiomyocytes on Fibronectin‐Based Hydrogels

Advanced Healthcare Materials, EarlyView.
We introduce fibronectin‐based PEG hydrogels with controlled rigidity to enable the culture of iPSC‐derived cardiomyocytes. These substrates offer an alternative to the current culture of these cells on fibronectin‐coated glass, providing enhanced structural and functional behavior. The system provides a more physiologically relevant platform to assess
Ana Da Silva Costa, Lineta Stonkute, Sara Trujillo, Mariana Azevedo Gonzalez Oliva, Francis Burton, Matthew J. Dalby, Oana Dobre, Godfrey Smith, Manuel Salmeron‐Sanchez   +8 more
wiley   +1 more source

Piezoelectric Surface Charge and Dynamic Stimulation Synergize to Promote Cardiac Myoblast Alignment and Maturation

Advanced Healthcare Materials, EarlyView.
Surface polarization of PVDF films combined with mechanical stimulation generates piezoelectric electrical cues that modulate cardiomyoblast behaviour. Non‐poled and poled PVDF substrates provide distinct electroactive microenvironments influencing cell adhesion, proliferation, and differentiation.
Rafaela M Meira, Sylvie Ribeiro, Senentxu Lanceros‐Mendez, Clarisse Ribeiro   +3 more
wiley   +1 more source

Cardiac Myosin Light Chain Kinase [PDF]

Circulation Research, 2008
See related article, pages 571–580 Muscle myosin, which is the highly conserved molecular motor, contains 1 pair of myosin heavy chains (MHCs) and 2 pairs of myosin light chains (MLCs), the latter of which are referred to as essential and regulatory light chains.1,2 It is well known that muscle myosin is regulated through the phosphorylation of ...
Yoshihiro Ishikawa, Reiko Kurotani
openaire   +1 more source

Expression of Smooth Muscle Myosin Heavy Chains and Unloaded Shortening in Single Smooth Muscle Cells [PDF]

, 1997
The functional significance of the variable expression of the smooth muscle myosin heavy chain (SM-MHC) tail isoforms, SM1 and SM2, was examined at the mRNA level (which correlates with the protein level) in individual permeabilized rabbit arterial ...
Eddinger, Thomas, Meer, Daniel P.
core   +1 more source

Microengineered Gradient Hydrogels for Mechanobiology

Advanced Healthcare Materials, EarlyView.
Gradient hydrogels are used to mimic the mechanical heterogeneity in native tissues, offering powerful in vitro platforms to study cell‐material interactions in diverse pathophysiological contexts. Here, we present a comprehensive review of the design and experimental considerations for stiffness gradient hydrogels, discussing exemplary achievements ...
Shin Wei Chong, Deepu Ashok, Anna Waterhouse, Marcela M. M. Bilek, Daniele Vigolo   +4 more
wiley   +1 more source

Production of monoclonal antibodies against Streptococcus mutans antigens Produção de anticorpos monoclonais contra antígenos de Streptococcus mutans

Brazilian Oral Research, 2006
Several studies have been conducted in the last decades aiming to obtain an anti-caries vaccine, however some studies have demonstrated cross reactivity between Streptococcus mutans surface antigens and the human cardiac tissue.
Antonio Carlos Victor Canettieri, Fujiko Yamasiro Kretchetoff, Cristiane Yumi Koga-Ito, Daniella Moreira, Fabio José Condino Fujarra, Carmelinda Schmidt Unterkircher   +5 more
doaj   +1 more source