Cardiac Myosin-Binding Protein-C Phosphorylation and Cardiac Function [PDF]
Circulation Research, 2005 The role of cardiac myosin binding protein-C (cMyBP-C) phosphorylation in cardiac physiology or pathophysiology is unclear. To investigate the status of cMyBP-C phosphorylation in vivo, we determined its phosphorylation state in stressed and unstressed mouse hearts.
Sakthivel, Sadayappan +9 more
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Cardiac myosin-binding protein C (MYBPC3) in cardiac pathophysiology [PDF]
Gene, 2015 More than 350 individual MYPBC3 mutations have been identified in patients with inherited hypertrophic cardiomyopathy (HCM), thus representing 40–50% of all HCM mutations, making it the most frequently mutated gene in HCM. HCM is considered a disease of the sarcomere and is characterized by left ventricular hypertrophy, myocyte disarray and diastolic ...
Lucie, Carrier +3 more
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Discovery of (S)-3′-hydroxyblebbistatin and (S)-3′-aminoblebbistatin : polar myosin II inhibitors with superior research tool properties [PDF]
, 2017 In search of myosin II inhibitors with superior research tool properties, a chemical optimization campaign of the blebbistatin scaffold was conducted in this paper. (S)-Blebbistatin is the best known small-molecule inhibitor of myosin II ATPase activity.
Bracke, Marc +6 more
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Cardiac myosin binding protein C phosphorylation in cardiac disease [PDF]
Journal of Muscle Research and Cell Motility, 2011 Perturbations in sarcomeric function may in part underlie systolic and diastolic dysfunction of the failing heart. Sarcomeric dysfunction has been ascribed to changes in phosphorylation status of sarcomeric proteins caused by an altered balance between intracellular kinases and phosphatases during the development of cardiac disease.
Kuster DWD +5 more
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Aberrant splicing and expression of the non muscle myosin heavy-chain gene MYH14 in DM1 muscle tissues [PDF]
, 2012 Myotonic dystrophy type 1 (DM1) is a complex multisystemic disorder caused by an expansion of a CTG repeat located at the 3' untranslated region (UTR) of DMPK on chromosome 19q13.3.
Angelini, C +10 more
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Serum Response Factor in muscle tissues: from development to ageing
European Journal of Translational Myology, 2016 Skeletal, cardiac and smooth muscle cells share various common characteristic features. During development the embryonic mesodermal layer contribute at different proportions to the formation of these tissues.
Dario Coletti +4 more
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Multiple myosin motors interact with sodium/potassium-ATPase alpha 1 subunits
Molecular Brain, 2018 The alpha1 (α1) subunit of the sodium/potassium ATPase (i.e., Na+/K+-ATPase α1), the prototypical sodium pump, is expressed in each eukaryotic cell. They pump out three sodium ions in exchange for two extracellular potassium ions to establish a cellular ...
Bhagirathi Dash +2 more
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Cardiac Myosin Adenosinetriphosphatase Activity [PDF]
Circulation Research, 1966 Cardiac myosin prepared by any one of a number of modifications of the basic Szent-Gyorgyi method and cardiac myosin prepared by the lithium chloride-ammonium sulfate technique differ in two important respects: 1) Szent-Gyorgyi-prepared myosin solutions are inhomogeneous by both chemical and immunologic criteria; 2) the ATPase activity of Szent-Gyorgyi-
R J, Luchi, E M, Kritcher
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Mouse models for the study of postnatal cardiac hypertrophy
International Journal of Cardiology: Heart & Vasculature, 2015 The main objective of this study was to create a postnatal model for cardiac hypertrophy (CH), in order to explain the mechanisms that are present in childhood cardiac hypertrophy.
A. Del Olmo-Turrubiarte +8 more
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Differential expression of skeletal muscle genes following administration of clenbuterol to exercised horses. [PDF]
, 2016 BackgroundClenbuterol, a beta2-adrenergic receptor agonist, is used therapeutically to treat respiratory conditions in the horse. However, by virtue of its mechanism of action it has been suggested that clenbuterol may also have repartitioning affects in
Chouicha, Nadira +4 more
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