Results 21 to 30 of about 6,676 (255)

Novel blood coagulation molecules: Skeletal muscle myosin and cardiac myosin

Journal of Thrombosis and Haemostasis, 2021
Essentials Striated muscle myosins can promote prothrombin activation by FXa or FVa inactivation by APC. Cardiac myosin and skeletal muscle myosin are pro-hemostatic in murine tail cut bleeding models. Infused cardiac myosin exacerbates myocardial injury caused by myocardial ischemia reperfusion.
Deguchi, Hiroshi, Morla, Shravan, Griffin, John H.   +2 more
openaire   +3 more sources

Mechanosensing in myosin filament solves a 60 years old conflict in skeletal muscle modeling between high power output and slow rise in tension [PDF]

, 2016
Almost 60 years ago Andrew Huxley with his seminal paper \cite{Huxley1957} laid the foundation of modern muscle modeling, linking chemical events to mechanical performance.
Marcucci, Lorenzo, Reggiani, Carlo
core   +3 more sources

Ensemble Force Changes that Result from Human Cardiac Myosin Mutations and a Small-Molecule Effector

Cell Reports, 2015
Cardiomyopathies due to mutations in human β-cardiac myosin are a significant cause of heart failure, sudden death, and arrhythmia. To understand the underlying molecular basis of changes in the contractile system’s force production due to such mutations
Tural Aksel, Elizabeth Choe Yu, Shirley Sutton, Kathleen M. Ruppel, James A. Spudich   +4 more
doaj   +1 more source

Molecular Characteristics of Canine Cardiac Myosin [PDF]

Circulation Research, 1965
Cardiac myosin was obtained from the hearts of normal dogs by conventional extraction and precipitation techniques, followed by ammonium sulfate fractionation in the presence of 2.0 M lithium chloride. The molecular characteristics of this protein preparation are presented. Cardiac myosin prepared by this technique shows less tendency than
R J, LUCHI, E M, KRITCHER, H L, CONN
openaire   +2 more sources

Hypertrophic cardiomyopathy: Translating cellular cross talk into therapeutics [PDF]

, 2013
Hypertrophic cardiomyopathy (HCM) is a common inherited heart disease with serious adverse outcomes, including heart failure, arrhythmias, and sudden cardiac death.
Padera, Robert Francis, Seidman, Christine Edry, Seidman, Jonathan G., Teekakirikul, Polakit   +3 more
core   +1 more source

Heavy and light roles: myosin in the morphogenesis of the heart [PDF]

, 2012
Myosin is an essential component of cardiac muscle, from the onset of cardiogenesis through to the adult heart. Although traditionally known for its role in energy transduction and force development, recent studies suggest that both myosin heavy-chain ...
A Abu-Daya, A Du, A Horowitz, A Houmeida, A Wessels, AA Lagrutta, AE Chambers, AN Tullio, AS Warkman, AV Postma, B Brenner, BA Danowski, BG Bruneau, BN Davis, BR Cullen, BS Budde, BS Pan, BV Latinkic, C Gove, C Huang, C Rutland, C Wang, CR Bagshaw, CS Rutland, CT Basson, D Franco, D Franco, D Hailstones, D Jin, D Linde van der, D Maughan, D Mornet, D Rhee, D Yelon, DJ Timson, DM Alvarado, DO Fürst, E Berdougo, E Carniel, E Eisenberg, E Flashman, E Rooij van, E Rooij van, EM Small, EP Kirk, F Charron, G Bonne, GE Lyons, H Huxley, H Niimura, H Pannu, H Suzuki, H Wada, HJ Auman, HJ Li, HL Sweeney, HM Warrick, I Morano, I Morano, I Rayment, J Chen, J Fewell, J Flavigny, J Gulick, J Stull, JD Molkentin, Jennifer England, JGF Cleland, JJ Schott, JM Miano, JP Sluijter, JS Davis, JS Park, JT Granados-Riveron, JY Chan, K Imanaka-Yoshida, K Poetter, K Takeda, K Trybus, KD Wilson, KK Turnacioglu, KM Price, KN Ivey, KT Tokuyasu, L Khait, L Zhu, L Zhu, LD Sacks, LM Auckland, M Arad, M Chandra, M Goujon, M Maitra, M Morano, M Xin, MA Geeves, MA Larkin, MC Schaub, MG Posch, MJ Macera, ML Bell, MS Parmacek, N Liu, ND Epstein, ND Moncrief, O Ogut, O Ritter, P Andersen, P Richard, P VanBuren, P Vibert, PFM Ven Van Der, PJ Barton, PJ Barton, PJ Reiser, PS Andersen, Q Shi, QY Li, R Nishigaki, R Walsh, RE Cheney, RE Hershberger, RJ Garriock, RL Moss, RM Toydemir, S Ghatpande, S Goswami, S Lu, S Machida, S Somi, Siobhan Loughna, SJ Smith, SS Lehrer, SW Kubalak, T Boettger, T Takaya, TE Callis, TM Olson, TQP Uyeda, TX O’Brien, V Garg, VJ Ferrans, W Barillot, W Dillmann, W Lehman, W Lu, W Rottbauer, W-H Lee, WF Harrington, WF Harrington, WK Jones, WL Fodor, X Ma, X Ma, Y Hiroi, Y Ishikawa, Y Nakajima, Y Taneda, Y Yang, YH Ching, Z Chen, Z Wang, ZT Kabaeva, ZZ Bao   +163 more
core   +3 more sources

Myosinome: A Database of Myosins from Select Eukaryotic Genomes to Facilitate Analysis of Sequence-Structure-Function Relationships

Bioinformatics and Biology Insights, 2012
Myosins are one of the largest protein superfamilies with 24 classes. They have conserved structural features and catalytic domains yet show huge variation at different domains resulting in a variety of functions.
Divya P. Syamaladevi, Margaret S Sunitha, S. Kalaimathy, Chandrashekar C. Reddy, Mohammed Iftekhar, Shaik N. Pasha, R. Sowdhamini   +6 more
doaj   +1 more source

The myosin activator omecamtiv mecarbil: a promising new inotropic agent [PDF]

, 2018
K
Nánási, Péter Pál ifj., Papp, Zoltán, Váczi, Krisztina   +2 more
core   +1 more source

Loss of function of myosin chaperones triggers Hsf1-mediated transcriptional response in skeletal muscle cells [PDF]

, 2015
Quality of sequences obtained with CASAVA 1.8.1 (Illumina) workflow. PF reads passing Illumina chastity filter.
Christelle Etard, Marco Ferg, Olivier Armant, Urmas Roostalu, Uwe Strähle, Victor Gourain   +5 more
core   +3 more sources

Effects of myosin variants on interacting-heads motif explain distinct hypertrophic and dilated cardiomyopathy phenotypes

eLife, 2017
Cardiac β-myosin variants cause hypertrophic (HCM) or dilated (DCM) cardiomyopathy by disrupting sarcomere contraction and relaxation. The locations of variants on isolated myosin head structures predict contractility effects but not the prominent ...
Lorenzo Alamo, James S Ware, Antonio Pinto, Richard E Gillilan, Jonathan G Seidman, Christine E Seidman, Raúl Padrón   +6 more
doaj   +1 more source