Results 21 to 30 of about 4,049 (222)
eLife, 2017 Cardiac β-myosin variants cause hypertrophic (HCM) or dilated (DCM) cardiomyopathy by disrupting sarcomere contraction and relaxation. The locations of variants on isolated myosin head structures predict contractility effects but not the prominent ...
Lorenzo Alamo +6 more
doaj +1 more source
Cardiac Myosin Adenosinetriphosphatase of Rat and Mouse [PDF]
Circulation Research, 1974 Cardiac myosin obtained from rats and mice (smaller animals) had a higher adenosinetriphosphatase (ATPase) activity in the presence of calcium ions (Ca 2+ ) than did cardiac myosin from rabbits and dogs (larger animals).
Y, Yazaki, M S, Raben
openaire +2 more sources
Functional Characterization of Cardiac Myosin Isoforms.
The Japanese Journal of Physiology, 1998 In this brief review, we have discussed the functional significance of cardiac myosin isoform redistribution. The development of in vitro motility assay techniques has greatly aided the research in this field. The next important step would be the integration of data at molecular or cellular level to account for the pathophysiology of animal or human ...
SUGIURA, Seiryo, YAMASHITA, Hiroshi
openaire +3 more sources
Serum Response Factor in muscle tissues: from development to ageing
European Journal of Translational Myology, 2016 Skeletal, cardiac and smooth muscle cells share various common characteristic features. During development the embryonic mesodermal layer contribute at different proportions to the formation of these tissues.
Dario Coletti +4 more
doaj +1 more source
Multiple myosin motors interact with sodium/potassium-ATPase alpha 1 subunits
Molecular Brain, 2018 The alpha1 (α1) subunit of the sodium/potassium ATPase (i.e., Na+/K+-ATPase α1), the prototypical sodium pump, is expressed in each eukaryotic cell. They pump out three sodium ions in exchange for two extracellular potassium ions to establish a cellular ...
Bhagirathi Dash +2 more
doaj +1 more source
Are the class 18 myosins Myo18A and Myo18B specialist sarcomeric proteins?
Frontiers in PhysiologyInitially, the two members of class 18 myosins, Myo18A and Myo18B, appeared to exhibit highly divergent functions, complicating the assignment of class-specific functions.
Markus Horsthemke +3 more
doaj +1 more source
Mouse models for the study of postnatal cardiac hypertrophy
International Journal of Cardiology: Heart & Vasculature, 2015 The main objective of this study was to create a postnatal model for cardiac hypertrophy (CH), in order to explain the mechanisms that are present in childhood cardiac hypertrophy.
A. Del Olmo-Turrubiarte +8 more
doaj +1 more source
Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach +23 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz +9 more
wiley +1 more source
Bioprinting High‐Cell‐Density Cardiac Tissue Constructs With Sustained Contractile Function
Advanced Healthcare Materials, EarlyView.Contractile cardiomyocytes in 3D culture provide insights into the behavior of the heart. Combining a 3D bioprinting approach with a multi‐electrode array allows the development of the 3D culture to be monitored over time, and matured cultures allow the effect of drugs on cardiac function to be modelled, replicating effects seen in clinical application.
Priscila Melo +8 more
wiley +1 more source