Results 1 to 10 of about 4,202 (274)
Single cardiac ventricular myosins are autonomous motors [PDF]
Open Biology, 2018 Myosin transduces ATP free energy into mechanical work in muscle. Cardiac muscle has dynamically wide-ranging power demands on the motor as the muscle changes modes in a heartbeat from relaxation, via auxotonic shortening, to isometric contraction.
Yihua Wang +4 more
doaj +2 more sources
Cryo-EM structure of the folded-back state of human β-cardiac myosin [PDF]
Nature Communications, 2023 To save energy and precisely regulate cardiac contractility, cardiac muscle myosin heads are sequestered in an ‘off’ state that can be converted to an ‘on’ state when exertion is increased. The ‘off’ state is equated with a folded-back structure known as
Alessandro Grinzato +10 more
doaj +3 more sources
The ancient sarcomeric myosins found in specialized muscles
Skeletal Muscle, 2019 Striated muscles express an array of sarcomeric myosin motors that are tuned to accomplish specific tasks. Each myosin isoform found in muscle fibers confers unique contractile properties to the fiber in order to meet the demands of the muscle.
Lindsey A. Lee +3 more
doaj +3 more sources
Research into the physiology of myosins - a personal odyssey [PDF]
European Journal of Translational MyologyDuring my PhD, I worked on the neural regulation of mechanical properties fast and slow muscles. This led me to believe that myosins in fast and slow muscles are structurally distinct and that motor nerves regulate the expression of myosin genes.
Joseph Foon Yoong Hoh
doaj +2 more sources
Therapeutic Advances in Chronic Disease, 2022 Hypertrophic cardiomyopathy (HCM) is a common genetic disorder characterised by unexplained left ventricular hypertrophy. Left ventricular outflow tract obstruction is an integral component of the disease, often resulting in significant symptoms, but ...
Susan Mathai, Lynne Williams
doaj +1 more source
To lie or not to lie: Super-relaxing with myosins
eLife, 2021 Since the discovery of muscle in the 19th century, myosins as molecular motors have been extensively studied. However, in the last decade, a new functional super-relaxed (SRX) state of myosin has been discovered, which has a 10-fold slower ATP turnover ...
Suman Nag, Darshan V Trivedi
doaj +1 more source
MYH10 activation rescues contractile defects in arrhythmogenic cardiomyopathy (ACM)
Nature Communications, 2023 The most prevalent genetic form of inherited arrhythmogenic cardiomyopathy (ACM) is caused by mutations in desmosomal plakophilin-2 (PKP2). By studying pathogenic deletion mutations in the desmosomal protein PKP2, here we identify a general mechanism by ...
Nieves García-Quintáns +16 more
doaj +1 more source
PLoS ONE, 2021 To gain insight on the impact of preventive exercise during pulmonary arterial hypertension (PAH), we evaluated the gene expression of myosins and gene-encoding proteins associated with the extracellular matrix remodeling of right hypertrophied ...
Thaoan Bruno Mariano +11 more
doaj +1 more source
Molecules, 2022 Milk represents an integrated meal for newborns; its whey protein is rich in many health beneficial components and proteins. The current study aimed to investigate the differences between colostrum and mature milk from Mediterranean and Murrah buffaloes ...
Mahmoud Abdel-Hamid +8 more
doaj +1 more source
Myosin modulators: emerging approaches for the treatment of cardiomyopathies and heart failure
The Journal of Clinical Investigation, 2022 Myosin modulators are a novel class of pharmaceutical agents that are being developed to treat patients with a range of cardiomyopathies. The therapeutic goal of these drugs is to target cardiac myosins directly to modulate contractility and cardiac ...
Sharlene M. Day +2 more
doaj +1 more source