Results 11 to 20 of about 6,676 (255)
Direct regulation of striated muscle myosins by nitric oxide and endogenous nitrosothiols.
PLoS ONE, 2010 BackgroundNitric oxide (NO) has long been recognized to affect muscle contraction, both through activation of guanylyl cyclase and through modification of cysteines in proteins to yield S-nitrosothiols. While NO affects the contractile apparatus directly,
Alicia M Evangelista +7 more
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The ancient sarcomeric myosins found in specialized muscles
Skeletal Muscle, 2019 Striated muscles express an array of sarcomeric myosin motors that are tuned to accomplish specific tasks. Each myosin isoform found in muscle fibers confers unique contractile properties to the fiber in order to meet the demands of the muscle.
Lindsey A. Lee +3 more
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Myosin modulators: emerging approaches for the treatment of cardiomyopathies and heart failure
The Journal of Clinical Investigation, 2022 Myosin modulators are a novel class of pharmaceutical agents that are being developed to treat patients with a range of cardiomyopathies. The therapeutic goal of these drugs is to target cardiac myosins directly to modulate contractility and cardiac ...
Sharlene M. Day +2 more
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Frontiers in Cardiovascular Medicine, 2022 In this study, we investigated the rescue potential of two phosphomimetic mutants of the myosin regulatory light chain (RLC, MYL2 gene), S15D, and T160D RLCs.
Katarzyna Kazmierczak +3 more
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The emergence of Pax7-expressing muscle stem cells during vertebrate head muscle development [PDF]
, 2015 Pax7 expressing muscle stem cells accompany all skeletal muscles in the body and in healthy individuals, efficiently repair muscle after injury. Currently, the in vitro manipulation and culture of these cells is still in its infancy, yet muscle stem ...
Anna eNoble +9 more
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Biology Open, 2021 The fundamental basis of muscle contraction ‘the sliding filament model’ (Huxley and Niedergerke, 1954; Huxley and Hanson, 1954) and the ‘swinging, tilting crossbridge-sliding filament mechanism’ (Huxley, 1969; Huxley and Brown, 1967) nucleated a field ...
Manuel Schmid, Christopher N. Toepfer
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Developing cardiac and skeletal muscle share fast-skeletal myosin heavy chain and cardiac troponin-I expression [PDF]
, 2012 Skeletal muscle derived stem cells (MDSCs) transplanted into injured myocardium can differentiate into fast skeletal muscle specific myosin heavy chain (sk-fMHC) and cardiac specific troponin-I (cTn-I) positive cells sustaining recipient myocardial ...
A Du +39 more
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Human Cardiac Myosin: Electron Microscopic Observations [PDF]
Circulation Research, 1965 Solutions of human cardiac myosin contain macromolecules which were visualized in the electron microscope by the shadow-casting technic. The dominant particle was observed to be rod-shaped, to have a globular expansion at one end, and to have a mean length of about 1500 Å. The molecule of human cardiac myosin was found to be morphologically similar to
J A, Carney, A L, Brown
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Binding pocket dynamics along the recovery stroke of human β-cardiac myosin.
PLoS Computational Biology, 2023 The druggability of small-molecule binding sites can be significantly affected by protein motions and conformational changes. Ligand binding, protein dynamics and protein function have been shown to be closely interconnected in myosins.
Fariha Akter +2 more
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Cardiac Myosin Binding Protein C [PDF]
Circulation Research, 1999 Abstract —Myosin binding protein C (MyBP-C) is one of a group of myosin binding proteins that are present in the myofibrils of all striated muscle. The protein is found at 43-nm repeats along 7 to 9 transverse lines in a portion of the A band where crossbridges are found (C zone).
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