Results 11 to 20 of about 4,202 (274)

Myosinome: A Database of Myosins from Select Eukaryotic Genomes to Facilitate Analysis of Sequence-Structure-Function Relationships

Bioinformatics and Biology Insights, 2012
Myosins are one of the largest protein superfamilies with 24 classes. They have conserved structural features and catalytic domains yet show huge variation at different domains resulting in a variety of functions.
Divya P. Syamaladevi, Margaret S Sunitha, S. Kalaimathy, Chandrashekar C. Reddy, Mohammed Iftekhar, Shaik N. Pasha, R. Sowdhamini   +6 more
doaj   +2 more sources

Ensemble Force Changes that Result from Human Cardiac Myosin Mutations and a Small-Molecule Effector

Cell Reports, 2015
Cardiomyopathies due to mutations in human β-cardiac myosin are a significant cause of heart failure, sudden death, and arrhythmia. To understand the underlying molecular basis of changes in the contractile system’s force production due to such mutations
Tural Aksel, Elizabeth Choe Yu, Shirley Sutton, Kathleen M. Ruppel, James A. Spudich   +4 more
doaj   +2 more sources

Are the class 18 myosins Myo18A and Myo18B specialist sarcomeric proteins? [PDF]

Frontiers in Physiology
Initially, the two members of class 18 myosins, Myo18A and Myo18B, appeared to exhibit highly divergent functions, complicating the assignment of class-specific functions.
Markus Horsthemke, Charles-Adrien Arnaud, Charles-Adrien Arnaud, Peter J. Hanley   +3 more
doaj   +2 more sources

Functional comparison of phosphomimetic S15D and T160D mutants of myosin regulatory light chain exchanged in cardiac muscle preparations of HCM and WT mice

Frontiers in Cardiovascular Medicine, 2022
In this study, we investigated the rescue potential of two phosphomimetic mutants of the myosin regulatory light chain (RLC, MYL2 gene), S15D, and T160D RLCs.
Katarzyna Kazmierczak, Jingsheng Liang, Michelle Gomez-Guevara, Danuta Szczesna-Cordary   +3 more
doaj   +2 more sources

Mouse models for the study of postnatal cardiac hypertrophy

International Journal of Cardiology: Heart & Vasculature, 2015
The main objective of this study was to create a postnatal model for cardiac hypertrophy (CH), in order to explain the mechanisms that are present in childhood cardiac hypertrophy.
A. Del Olmo-Turrubiarte, A. Calzada-Torres, G. Díaz-Rosas, I. Palma-Lara, R. Sánchez-Urbina, N.A. Balderrábano-Saucedo, H. González-Márquez, P. Garcia-Alonso, A. Contreras-Ramos   +8 more
doaj   +2 more sources

Unraveling the evolutionary origin of the complex Nuclear Receptor Element (cNRE), a cis-regulatory module required for preferential expression in the atrial chamber

Communications Biology
Cardiac function requires appropriate proteins in each chamber. Atria requires slow myosin to act as reservoirs, while ventricles demand fast myosin for swift pumping.
Luana Nunes Santos, Ângela Maria Sousa Costa, Martin Nikolov, João E. Carvalho, Allysson Coelho Sampaio, Frank E. Stockdale, Gang Feng Wang, Hozana Andrade Castillo, Mariana Bortoletto Grizante, Stefanie Dudczig, Michelle Vasconcelos, Nadia Rosenthal, Patricia Regina Jusuf, Hieu T. Nim, Paulo de Oliveira, Tatiana Guimarães de Freitas Matos, William Nikovits, Izabella Luisa Tambones, Ana Carolina Migliorini Figueira, Michael Schubert, Mirana Ramialison, José Xavier-Neto   +21 more
doaj   +3 more sources

Spatially resolving how cMyBP-C phosphorylation and haploinsufficiency in porcine and human myofibrils affect β-cardiac myosin activity. [PDF]

J Gen Physiol
β-cardiac myosin mediates cardiac muscle contraction within the sarcomere by binding to the thin filament in an ATP-powered reaction. This process is highly regulated on a beat-to-beat basis by calcium interactions with the thin filament, but also ...
Pilagov M, Steczina S, Naim A, Regnier M, Geeves MA, Kad NM.   +5 more
europepmc   +2 more sources

Identification of functional differences between recombinant human ? and ? cardiac myosin motors [PDF]

, 2012
The myosin isoform composition of the heart is dynamic in health and disease and has been shown to affect contractile velocity and force generation.
Rezavandi, Heresh, Rezavandi, H., Leslie A. Leinwand, Geeves, M., Leinwand, Leslie A., Leinwand, L., Geeves, Michael A., Marieke J. Bloemink, Heresh Rezavandi, Deacon, John C., Bloemink, Marieke J., Deacon, J., John C. Deacon, Bloemink, M., Michael A. Geeves   +14 more
core   +1 more source

Cardiac myosin super relaxation (SRX): a perspective on fundamental biology, human disease and therapeutics

Biology Open, 2021
The fundamental basis of muscle contraction ‘the sliding filament model’ (Huxley and Niedergerke, 1954; Huxley and Hanson, 1954) and the ‘swinging, tilting crossbridge-sliding filament mechanism’ (Huxley, 1969; Huxley and Brown, 1967) nucleated a field ...
Manuel Schmid, Christopher N. Toepfer
doaj   +1 more source

Binding pocket dynamics along the recovery stroke of human β-cardiac myosin.

PLoS Computational Biology, 2023
The druggability of small-molecule binding sites can be significantly affected by protein motions and conformational changes. Ligand binding, protein dynamics and protein function have been shown to be closely interconnected in myosins.
Fariha Akter, Julien Ochala, Arianna Fornili   +2 more
doaj   +1 more source