Results 171 to 180 of about 181,328 (267)

Unnecessary fluid therapy in patients with shock: Five classic fluid pitfalls and five ways to do it better. [PDF]

Ann Intensive Care
Vanden Eede M, Van Regenmortel N.
europepmc   +1 more source

AI‐Designed Cyclic Peptides Enable Controllable Modulation of the CD28 Immune Checkpoint

Advanced Science, EarlyView.
AI‐designed cyclic peptides enable controllable modulation of the CD28 immune checkpoint through reversible disruption of CD28‐CD80/CD86 interactions. The lead peptide, CIP‐3, suppresses T‐cell activation without intrinsic agonist activity, demonstrates dose‐dependent efficacy in a murine colitis model, and attenuates inflammatory cytokine production ...
Katarzyna Kuncewicz, Saurabh Upadhyay, Renjie Zhu, Hongliang Duan, Moustafa T. Gabr   +4 more
wiley   +1 more source

Cardiorenal Syndrome Type 1 Complicated by Uremic Pericarditis and a Small Pericardial Effusion Causing Cardiac Tamponade. [PDF]

Cureus
Khoury F, Govil D, Kosako-Yost K, Lin K, Singarajah C.   +4 more
europepmc   +1 more source

Leonurine Ameliorates Doxorubicin‐Induced Cardiotoxicity via STING/NF‐κB/NLRP3 Inflammasome Signaling Pathway

Advanced Science, EarlyView.
ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun, Chen Xiaoyang, Xu Jianglin, Yang Zhi, Tao Meijiao, He Jiale, Zhao Jiangfeng, Hei Xuanding, Xu Xuegong, Wang Wei, Li Chun   +10 more
wiley   +1 more source

The Geometry of Circulatory Shock: A Conceptual Multi-Scale Lagrangian Framework for Physiology-Informed Hemodynamic Phenotyping. [PDF]

J Clin Med
Chalkias A, Katsifa K, Amanetopoulou S, Karapiperis G, Destounis A, Iatrelli I, Laou E, Prekates A, Tselioti P.   +8 more
europepmc   +1 more source

Accurately Deciphering Tissue Heterogeneity From Spatial Multi‐Modal and Multi‐Omics With STransformer

Advanced Science, EarlyView.
STransformer is a unified deep learning framework designed to seamlessly accommodate a comprehensive landscape of spatial data. By simultaneously capturing short‐range cellular interactions and tissue‐wide semantic patterns, it extracts robust representations to accurately dissect complex tissue heterogeneity.
Xingyi Li, Jialuo Xu, Gaoyuan Du, Xiangting Jia, Dongmin Zhao, Chunyan Zhou, Kexin Xiao, Jia Gu, Junnan Zhu, Xuequn Shang   +9 more
wiley   +1 more source

Cardiogenic shock is not a single entity: therapeutic implications. [PDF]

Eur Heart J Suppl
Marini M, Coraducci F, Shkoza M, Manfredi R, Belfioretti L, Angelini L, Pongetti G, Matassini MV, Battistoni I, Francioni M.   +9 more
europepmc   +1 more source

In‐Process Magnetization for 3D Printing of Magnetorheological Elastomer with Heterogeneous Magnetic Profile for Anisotropic Actuation

Advanced Science, EarlyView.
Fully programmable, in‐process 3D magnetization integrated with multi‐material printing enables soft magnetic systems with precise actuation and sensing. Discrete and continuous magnetization profiles drive bending, morphing, and locomotion, demonstrated through strain‐sensing elements, dragonfly‐inspired wings, octopus‐like tentacles, and a serpentine
Phillip Glass, David Hassouna, Udena Epitawala Arachchige, Hyeon Yun Jeong, Sung Hyun Park, Daeha Joung   +5 more
wiley   +1 more source

Integrated Hemodynamic Measures of Cardiac Function and Association With Clinical Outcomes. [PDF]

JACC Adv
Trad OK, Parekh JK, Kosyakovsky LB, Mounsey L, Pomerantsev EV, Picard MH, Quintero Pinzon PA, Sabe M, Grandin EW, Garan AR, Ho JE.   +10 more
europepmc   +1 more source