Results 111 to 120 of about 1,084,670 (306)

Advancements in tissue engineering for cardiovascular health: a biomedical engineering perspective

Frontiers in Bioengineering and Biotechnology
Myocardial infarction (MI) stands as a prominent contributor to global cardiovascular disease (CVD) mortality rates. Acute MI (AMI) can result in the loss of a large number of cardiomyocytes (CMs), which the adult heart struggles to replenish due to its ...
Zahra-Sadat Razavi, Madjid Soltani, Madjid Soltani, Madjid Soltani, Golnaz Mahmoudvand, Simin Farokhi, Arian Karimi-Rouzbahani, Bahareh Farasati-Far, Samaneh Tahmasebi-Ghorabi, Hamidreza Pazoki-Toroudi, Hamed Afkhami, Hamed Afkhami, Hamed Afkhami   +12 more
doaj   +1 more source

Adenyl Cyclase in Cardiac Tissue

Journal of Biological Chemistry, 1970
Abstract Experiments were performed on adenyl cyclase in washed particles of guinea pig ventricle and in particulate preparations extracted with LiBr. The Km for ATP was 0.08 mm. Since one Mg++ binds with ATP at pH 7.5, it was concluded that the true substrate is a Mg-ATP complex.
G I, Drummond, L, Duncan
openaire   +2 more sources

Metabolic and cardiac adaptation to chronic pharmacologic blockade of facilitative glucose transport in murine dilated cardiomyopathy and myocardial ischemia [PDF]

, 2018
GLUT transgenic and knockout mice have provided valuable insight into the role of facilitative glucose transporters (GLUTs) in cardiovascular and metabolic disease, but compensatory physiological changes can hinder interpretation of these models.
Heitmeier, Monique R., Hresko, Richard C., Hruz, Paul W., Jay, Patrick Y., Kovacs, Attila, Payne, Maria A., Weinheimer, Carla   +6 more
core   +2 more sources

Cardiac‐Derived ECM Microspheres for Enhanced hiPSC‐CMs Maturation

Advanced Functional Materials, EarlyView.
Cardiac extracellular matrix microspheres derived from decellularized porcine heart provide a biomimetic 3D microenvironment for human induced pluripotent stem cell–derived cardiomyocytes (hiPSC‐CMs). This platform supports short‐ and long‐term culture, enhances structural organization, and promotes electrophysiological and functional maturation of ...
Jiazhu Xu, Joel Aboagye, Marcella Edwards, Nick Rogozinski, Yufeng Wen, Angello Huerta Gomez, Zui Pan, Ge Zhang, Huaxiao Yang, Yi Hong   +9 more
wiley   +1 more source

Protective effects of hypoxic conditioning treatment on brain and cardiac tissues following thoracic aorta occlusion

Brain Circulation
BACKGROUND: Thoracic aortic ischemia-reperfusion (I/R) injury occurs in clinical scenarios and can lead to damage in organs such as the spinal cord, kidneys, and intestines.
Jun Xu, Fang Tong, Yumeng Wang, Sijie Li, Wenbo Zhao, Xiaomei Tian, Fengyong Liu, Xunming Ji, Changhong Ren   +8 more
doaj   +1 more source

Relation of cardiac adipose tissue to coronary calcification and myocardial microvascular function in type 1 and type 2 diabetes

Cardiovascular Diabetology, 2020
Background Cardiac adipose tissue may have local paracrine effects on epicardial arteries and the underlying myocardium, promoting calcification and affecting myocardial microcirculation. We explored whether the total amount of cardiac adipose tissue was
Emilie H. Zobel, Regitse Højgaard Christensen, Signe A. Winther, Philip Hasbak, Christian Stevns Hansen, Bernt J. von Scholten, Lene Holmvang, Andreas Kjaer, Peter Rossing, Tine W. Hansen   +9 more
doaj   +1 more source

PRELIVE: A Framework for Predicting Lipid Nanoparticles In Vivo Efficacy and Reducing Reliance on Animal Testing

Advanced Functional Materials, EarlyView.
PREdicting LNP In Vivo Efficacy (PRELIVE) framework enables the prediction of lipid nanoparticle (LNPs) organ‐specific delivery through dual modeling approaches. Composition‐based models using formulation parameters and protein corona‐based models using biological fingerprints both achieve high predictive accuracy across multiple organs.
Belal I. Hanafy, Chuan‐En Lu, Kai Liu, Audrey Gallud   +3 more
wiley   +1 more source

A bioprinted cardiac patch composed of cardiac-specific extracellular matrix and progenitor cells for heart repair [PDF]

, 2018
Congenital heart defects are present in 8 of 1000 newborns and palliative surgical therapy has increased survival. Despite improved outcomes, many children develop reduced cardiac function and heart failure requiring transplantation.
Bejleri, Donald, Brown, Milton E., Christman, Karen L., Davis, Michael E., Gaetani, Roberto, Nachlas, Aline L. Y., Streeter, Benjamin W.   +6 more
core   +1 more source

VIVID: A qPCR‐Based Platform for Sensitive and Quantitative In Vivo Tracking of Extracellular Vesicles

Advanced Functional Materials, EarlyView.
This study introduces VIVID (Vesicle In Vivo Identification using DNA), a qPCR‐based platform that tracks PCR‐amplifiable DNA tags loaded in the EVs for accurate and quantifiable EV biodistribution in vivo. ABSTRACT Extracellular vesicles (EVs) represent promising carriers for nucleic acid therapeutics, offering advantages over synthetic nanoparticles ...
Oscar Boyadjian, Talin Ebrahimian, Jonathan Miranda O'Connor, Janusz Rak, Stephanie Lehoux, Maryam Tabrizian   +5 more
wiley   +1 more source

Bio‐Inspired Molecular Events in Poly(Ionic Liquids)

Advanced Functional Materials, EarlyView.
Originating from dipolar and polar inter‐ and intra‐chain interactions of the building blocks, the topologies and morphologies of poly(ionic liquids) (PIL) govern their nano‐ and micro‐processibility. Modulating the interactions of cation‐anion pairs with aliphatic dipolar components enables the tunability of properties, facilitated by “bottom‐up ...
Jiahui Liu, Marek W. Urban
wiley   +1 more source