Results 51 to 60 of about 7,582 (165)

Mieap forms membrane-less organelles involved in cardiolipin metabolism

iScience
Summary: Biomolecular condensates (BCs) are formed by proteins with intrinsically disordered regions (IDRs) via liquid-liquid phase separation. Mieap/Spata18, a p53-inducible protein, participates in suppression of colorectal tumors by promoting ...
Naoki Ikari, Katsuko Honjo, Yoko Sagami, Yasuyuki Nakamura, Hirofumi Arakawa   +4 more
doaj   +1 more source

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

Cardiomyopathy in a c.1528G>C Hadha mouse is associated with cardiac tissue lipotoxicity and altered cardiolipin species

Journal of Lipid Research
Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency (LCHADD) is a metabolic disorder caused by the loss of LCHAD enzymatic activity in the α-subunit of the trifunctional protein (TFPα), leading to impaired fatty acid oxidation (FAO).
Chibuike Eke, Shannon Babcock, Garen Gaston, Gabriela Elizondo, Hak Chung, Ayah Asal, Kathryn C. Chatfield, Genevieve C. Sparagna, Andrea E. DeBarber, William Packwood, Jonathan R. Lindner, Melanie B. Gillingham   +11 more
doaj   +1 more source

Cardiolipin enhances protein C pathway anticoagulant activity

, 2000
The anticoagulant activity of activated protein C (APC) was studied using factor Xa-1-stage assays of both the procoagulant and anticoagulant activities of phospholipid vesicles containing phosphatidylserine or cardiolipin as active phospholipids. In the
Hackeng, TM; id_orcid, Griffin, JH, Petaja, J, Kojima, K, Fernandez, JA   +4 more
core   +1 more source

Negligible release of cardiolipin during milk secretion by the ruminant

Journal of Lipid Research, 1969
The presence of cardiolipin (diphosphatidyl glycerol) in lactating mammary tissue (cow and goat) was investigated. The tissue was separated into subcellular fractions by sedimentation; the identities of the fractions were confirmed by electron microscopy.
Stuart Patton, L.F. Hood, J.S. Patton
doaj   +1 more source

Role of cardiolipin in skeletal muscle function and its therapeutic implications

Cell Communication and Signaling
Cardiolipin, a unique phospholipid predominantly present in the inner mitochondrial membrane, is critical for maintaining mitochondrial integrity and function.
Youngbum Yoo, MyeongHoon Yeon, Mee-Sup Yoon, Young-Kyo Seo   +3 more
doaj   +1 more source

Effect of cardiolipin on the lamellarity and elongation of liposomes hydrated in PBS

Lamellarity and shape are important factors in the formation of vesicles and determine their role in biological systems and pharmaceutical applications. Cardiolipin (CL) is a major lipid in many biological membranes and exerts a great influence on their ...
Moussaoui, Dihia, Prévost, Sylvain, Piccinini, Alice, Winter, Anja, Kohlbrecher, Joachim   +4 more
core   +1 more source

Long‐Acting Therapeutics in Pediatric Health: Bridging Innovation and Access

Clinical Pharmacology &Therapeutics, EarlyView.
Children have distinct therapeutic needs arising from age‐dependent physiology, disease epidemiology, formulation requirements, dosing considerations, and safety vulnerabilities. Despite substantial reductions in childhood mortality over the past three decades, nearly 5 million children under five died in 2023, with infectious diseases continuing to ...
Prajith Venkatasubramanian, Moherndran Archary, Daniel B. Hawcutt, Rachel Daley, Edmund Capparelli, Adeniyi Olagunju   +5 more
wiley   +1 more source

Linoleic acid supplemention of Barth syndrome fibroblasts restores cardiolipin levels: implications for treatment

Journal of Lipid Research, 2003
The object of this study was to investigate whether the levels of cardiolipin in cultured skin fibroblasts of patients with Barth syndrome (BTHS) can be restored by addition of linoleic acid to growth media.
F. Valianpour, R.J.A. Wanders, H. Overmars, F.M. Vaz, P.G. Barth, A.H. van Gennip   +5 more
doaj   +1 more source

The cardiolipin analogues of Archaea [PDF]

, 2009
The present article reviews studies of the structure and functional roles of the cardiolipin analogues of extremely halophilic prokaryotes belonging to the Archaea domain.
CORCELLI, Angela
core   +1 more source