Results 71 to 80 of about 38,754 (240)

Linoleic acid supplemention of Barth syndrome fibroblasts restores cardiolipin levels: implications for treatment

open access: yesJournal of Lipid Research, 2003
The object of this study was to investigate whether the levels of cardiolipin in cultured skin fibroblasts of patients with Barth syndrome (BTHS) can be restored by addition of linoleic acid to growth media.
F. Valianpour   +5 more
doaj   +1 more source

Structure of an Inner Membrane Protein Required for PhoPQ-Regulated Increases in Outer Membrane Cardiolipin

open access: yesmBio, 2020
The Salmonella enterica subsp. enterica serovar Typhimurium PhoPQ two-component system is activated within the intracellular phagosome environment, where it promotes remodeling of the outer membrane and resistance to innate immune antimicrobial peptides.
Junping Fan   +4 more
doaj   +1 more source

Synthetic Approaches to Cardiolipin Analogs [PDF]

open access: yes, 2020
The first portion of this document describes the synthesis of three examples of the mitochondrial phospholipid cardiolipin with different fatty acid chain lengths and degrees of unsaturation.
Frasso, Michael
core  

Loss of cardiac tetralinoleoyl cardiolipin in human and experimental heart failure

open access: yesJournal of Lipid Research, 2007
The mitochondrial phospholipid cardiolipin is required for optimal mitochondrial respiration. In this study, cardiolipin molecular species and cytochrome oxidase (COx) activity were studied in interfibrillar (IF) and subsarcolemmal (SSL) cardiac ...
Genevieve C. Sparagna   +8 more
doaj   +1 more source

The physicochemical properties of cardiolipin bilayers and cardiolipin-containing lipid membranes

open access: yesBiochimica et Biophysica Acta (BBA) - Biomembranes, 2009
In this review article, we summarize the current state of biophysical knowledge concerning the phase behavior and organization of cardiolipin (CL) and CL-containing phospholipid bilayer model membranes. We first briefly consider the occurrence and distribution of CL in biological membranes and its probable biological functions therein. We next consider
Lewis, Ruthven N.A.H.   +1 more
openaire   +2 more sources

Lipid Coating Modulates Effects of Nanoceria on Oxidative Metabolism in Human Embryonic Lung Fibroblasts: A Case of Cardiolipin

open access: yesBiomolecules
The unique redox properties of nanoscale cerium dioxide determine its diverse application in biology and medicine as a regulator of oxidative metabolism. Lipid modifiers of the nanoparticle surface change their biochemical properties and bioavailability.
Elena V. Proskurnina   +9 more
doaj   +1 more source

Selective remodeling of cardiolipin fatty acids in the aged rat heart

open access: yesLipids in Health and Disease, 2006
Background The heart is rich in cardiolipin, a phospholipid acylated in four sites, predominately with linoleic acid. Whether or not aging alters the composition of cardiolipin acyl chains is controversial.
Rapoport Stanley I   +3 more
doaj   +1 more source

PTPMT1: Connecting Cardiolipin Biosynthesis to Mitochondrial Function [PDF]

open access: yes, 2011
Cardiolipin, a phospholipid component of the inner mitochondrial membrane, is required for mitochondrial metabolism. In this issue, Zhang et al. (2011) highlight a critical role for PTPMT1, a mitochondrial phosphatase, in cardiolipin biogenesis and ...
Tremblay, Michel L.   +3 more
core   +1 more source

Long‐Acting Therapeutics in Pediatric Health: Bridging Innovation and Access

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Children have distinct therapeutic needs arising from age‐dependent physiology, disease epidemiology, formulation requirements, dosing considerations, and safety vulnerabilities. Despite substantial reductions in childhood mortality over the past three decades, nearly 5 million children under five died in 2023, with infectious diseases continuing to ...
Prajith Venkatasubramanian   +5 more
wiley   +1 more source

Novel preparation of cardiolipin from beef heart

open access: yesJournal of Lipid Research, 1970
A new method is described for the isolation of beef heart cardiolipin. A lipid-protein complex, rich in cardiolipin, is obtained by a one-step solvent fractionation of the tissue total lipid extract. Cardiolipin in the complex is largely freed of protein
Joseph Eichberg, John D. Burnham
doaj   +1 more source

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