Results 61 to 70 of about 721,847 (303)

m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis

Advanced Science, EarlyView.
This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang, Jiadong Yu, Guolin Li, Ya Li, Fanlian Zeng, Jing Hu, Yifan Zhou, Chengcheng Yue, Qixiang Zhao, Chen Zhang, Hong Zhou, Fulei Zhao, Yawen Hu, Pei Zhou, Linna Gu, Yuting Feng, Mingxiang He, Shishi Huang, Xiaochi Sun, Xinmeng Wang, Jie Tang, Xinyu Zeng, Wenling Wu, Nongyu Huang, Xinai Cui, Kaijun Cui, Jiong Li   +26 more
wiley   +1 more source

Early Prediction of Sepsis From Clinical Data: The PhysioNet/Computing in Cardiology Challenge 2019

2019 Computing in Cardiology (CinC), 2019
The PhysioNet/Computing in Cardiology Challenge focused on the early detection of sepsis from clinical data. A total of 40,336 patient records from two distinct hospital systems were shared with participants while 22,761 patient records from three ...
PhD Matthew A. Reyna, MD Christopher S. Josef, PhD Russell Jeter, S. Shashikumar, M. P. M. Brandon Westover, PhD Shamim Nemati, G. D. C. DPhil, PhD Ashish Sharma, San Diego   +8 more
semanticscholar   +1 more source

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

Cardiology [PDF]

Postgraduate Medical Journal, 1990
L D, Smith, D J, Coltart
openaire   +2 more sources

Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy

Advanced Science, EarlyView.
Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee, Chul‐Gyun Lim, Pothiappan Vairaprakash, Jong‐Min Kim, Jiyoon Kim, Ji‐Young Park, Klaus M. Hahn, Hyunbo Shim, Hae Woong Choi, Tobias S. Ulmer, Soon Jun Hong, Chungho Kim   +11 more
wiley   +1 more source

Canadian Cardiovascular Society 2009 Consensus Conference on the management of adults with congenital heart disease: executive summary

, 2010
With advances in pediatric cardiology and cardiac surgery, the population of adults with congenital heart disease (CHD) has increased. In the current era, there are more adults with CHD than children.
Oechslin, Erwin, Meijboom, Folkert, Landzberg, Mike, Mital, Seema, Benson, Lee, Gary Webb, Dore, Annie, Omid Salehian, Timothy Bradley, Michael Connelly, Paul Khairy, Greutmann, Matthias, Marla Kiess, Webb, Gary, Barbara Mulder, Khairy, Paul, Celermajer, David, Louise Harris, Markus Schwerzmann, Luc Beauchesne, Baumgartner, Helmut, Lee Benson, Isabelle Vonder Muhll, Annie Dore, Silversides, Candice K., Beauchesne, Luc, Dylan Taylor, Ariane Marelli, David Celermajer, Connelly, Michael, Warnes, Carole, Judith Therrien, Carole Warnes, Mike Landzberg, Schwerzmann, Markus, Helmut Baumgartner, Vonder Muhll, Isabelle, Seema Mital, Eric Horlick, Matthias Greutmann, Mulder, Barbara, Jack Colman, Harris, Louise, Taylor, Dylan, Kiess, Marla, Folkert Meijboom, Nancy Poirier, Candice K. Silversides, Niwa, Koichiro, Erwin Oechslin, Horlick, Eric, Marelli, Ariane, Colman, Jack, Bradley, Timothy, Poirier, Nancy, Koichiro Niwa, Salehian, Omid, Therrien, Judith, Silversides, Candice K   +58 more
core   +1 more source

The use of diuretics in heart failure with congestion — a position statement from the Heart Failure Association of the European Society of Cardiology

European Journal of Heart Failure, 2019
The vast majority of acute heart failure episodes are characterized by increasing symptoms and signs of congestion with volume overload. The goal of therapy in those patients is the relief of congestion through achieving a state of euvolaemia, mainly ...
W. Mullens, K. Damman, V. Harjola, A. Mebazaa, H. Brunner-la Rocca, Pieter Martens, J. Testani, W. Tang, Francesco Orso, P. Rossignol, M. Metra, G. Filippatos, P. Seferovic, F. Ruschitzka, A. Coats   +14 more
semanticscholar   +1 more source

Biomimetic Bone Marrow Monocyte Membrane‐Fused Extracellular Vesicles for Targeted Therapy of Myocardial Infarction

Advanced Science, EarlyView.
This study develops a biomimetic delivery system (M‐hEV) by fusing monocyte membranes with extracellular vesicles for targeted therapy of damaged cardiac tissue. The system homes to injured myocardium through specific molecular pathways. In a myocardial infarction model, M‐hEV effectively accumulates in the heart, reduces infarct size, alleviates ...
Jiaxin Song, Hao Yang, Qiqi Zhang, Wenqin Zhou, Rui Wang, Yuxing Xie, Emeli Chatterjee, Guoping Li, Jizong Jiang, Qiulian Zhou, Cuimei Zhao   +10 more
wiley   +1 more source

Cardiology in primary care

, 2000
xviii+940hlm ...
SCHLANT, ROBRT C, ALEXANDER M.D, R WAYNE, CARDIOLOGY..........   +2 more
core  

European Society of Cardiology: Cardiovascular Disease Statistics 2019.

European Heart Journal, 2019
AIMS The 2019 report from the European Society of Cardiology (ESC) Atlas provides a contemporary analysis of cardiovascular disease (CVD) statistics across 56 member countries, with particular emphasis on international inequalities in disease burden and ...
A. Timmis, N. Townsend, C. Gale, A. Torbica, M. Lettino, Steffen Erhard Petersen, Elias Mossialos, A. Maggioni, D. Kazakiewicz, H. May, D. De Smedt, M. Flather, L. Zuhlke, J. Beltrame, R. Huculeci, L. Tavazzi, G. Hindricks, Jeroen J. Bax, B. Casadei, S. Achenbach, L. Wright, P. Vardas   +21 more
semanticscholar   +1 more source