Results 61 to 70 of about 896,131 (309)

A Soft Robotic Model for Simulating Heart Valve Disease and Cardiac Interventions

Advanced Science, EarlyView.
This paper introduces a fully synthetic fabrication methodology for a soft robotic, in‐vitro model of the left‐heart, complete with a functioning mitral valve apparatus. With a view towards patient‐specific modeling, we demonstrate physiological flow and pressure waveforms, tunable mitral valve function with clinical imaging compatibility, and its use ...
James Davies, Emanuele Nicotra, Kefan Zhu, Chi Cong Nguyen, Bibhu Sharma, Adrienne Ji, Phuoc Thien Phan, Jingjing Wan, Patrick Pruscino, Hermione Truong, Jelena Rnjak‐Kovacina, Hoang‐Phuong Phan, Christopher Hayward, Nigel Hamilton Lovell, Thanh Nho Do   +14 more
wiley   +1 more source

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

216 Jewish Hospital of St. Louis [PDF]

, 1984
https://digitalcommons.wustl.edu/bjc_216/1169/thumbnail ...

core   +1 more source

O‐GlcNAcylated TAP1 Impairs Antigen Presentation and Promotes Immune Evasion in Bladder Cancer

Advanced Science, EarlyView.
This article unveils a critical mechanism of immune evasion in bladder cancer, which the O‐GlcNAc modification of TAP1 disrupts antigen presentation. This modification triggers HLA‐A degradation, shielding tumor cells from CD8+ T cell attack. The findings highlight targeting this pathway as a promising therapeutic avenue to sensitize tumors to ...
Jinpeng Wu, Xueting Ren, Zhen Zhai, Lu Wang, Liang Liang, Zengqi Tan, Jiazhen Zhao, Yuxuan Han, Yuhan Li, Feng Guan, Xiang Li   +10 more
wiley   +1 more source

Right Internal Jugular Vein Access for Micra Leadless Pacemaker Implantation in a High-Risk Patient with Severe Iliac Vein Stenosis: A Case Report

International Medical Case Reports Journal
Haixiang Xu, Jianfeng Qian, Wen Pan, Jianhua Fan Department of Cardiology, Kunshan Hospital of Traditional Chinese Medicine Affiliated to Yangzhou University, Suzhou, People’s Republic of ChinaCorrespondence: Jianhua Fan, Department of Cardiology ...
Xu H, Qian J, Pan W, Fan J
doaj  

Barriers to cardiac rehabilitation delivery in a low-resource setting from the perspective of healthcare administrators, rehabilitation providers, and cardiac patients [PDF]

, 2019
Background: Despite clinical practice guideline recommendations that cardiovascular disease patients participate, cardiac rehabilitation (CR) programs are highly unavailable and underutilized. This is particularly true in low-resource settings, where the
Britto, Raquel, da Silva, Lilian Pinto, Duarte Novais Silva, Luciana, Grace, Sherry L., Lima de Melo Ghisi, Gabriela, Lima, Márcia Maria Oliveira, Pereira, Danielle Aparecida Gomes, Sérvio, Thaianne Cavalcante   +7 more
core   +2 more sources

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

Advanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu, Yaqian Cui, Yongqiang Zhou, Yihui Zheng, Lijiang Huang, Leiming Jin, Qianhui Zhang, Pan Chen, Mengsha Lin, Jiaxi Ye, Yongqiang Xiong, Joo Young Huh, Xiang Hu, Xiaokun Li, Wu Luo, Guang Liang   +15 more
wiley   +1 more source

Metformin Inhibits Inflammation by Targeting the NLRP3 Inflammasome: Linking NF-κB/NEK7/AMPK Signaling to Mitochondrial Function

Journal of Inflammation Research
Dingyi Ning,1,2 Chenxin Jiang,1 Jiangyan Zeng,3 Fanyun Zeng,3 Xuehong Zheng,4 Panpan Xia,5 Yunkun Liu,4 Xin Huang,4 Deju Zhang,6 Xiao Liu,7 Jing Zhang,8 Peng Yu4 1Queen Mary School, Nanchang University, Nanchang, 330006, People’s Republic of China; 2The ...
Ning D, Jiang C, Zeng J, Zeng F, Zheng X, Xia P, Liu Y, Huang X, Zhang D, Liu X, Zhang J, Yu P   +11 more
doaj  

Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy

Advanced Science, EarlyView.
Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee, Chul‐Gyun Lim, Pothiappan Vairaprakash, Jong‐Min Kim, Jiyoon Kim, Ji‐Young Park, Klaus M. Hahn, Hyunbo Shim, Hae Woong Choi, Tobias S. Ulmer, Soon Jun Hong, Chungho Kim   +11 more
wiley   +1 more source

Time-Weighted Cumulative High-Sensitivity C-Reactive Protein and Risk of Cardiac Conduction Block: Findings from a Prospective Cohort

Journal of Inflammation Research
Mo Zhang,1,2,* Dou Shi,1,* Yixiu Chen,2,3 Yicheng Liao,2,3 Zhihui Liu,2,3 Renjie Fu,2,3 Yufeng Bian,2,3 Shuohua Chen,2 Haiyan Zhao,2 Honghong He,2 Changhao Zu,2 Chunlu Liu,2 Hongqiu Huo,2 Shouling Wu,2 Yuntao Wu2 1Graduate School, Hebei ...
Zhang M, Shi D, Chen Y, Liao Y, Liu Z, Fu R, Bian Y, Chen S, Zhao H, He H, Zu C, Liu C, Huo H, Wu S, Wu Y   +14 more
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