Results 51 to 60 of about 734,643 (308)

Non-cardiology vs. cardiology care of patients with heart failure and reduced ejection fraction is associated with lower use of guideline-based care and higher mortality : Observations from The Swedish Heart Failure Registry

, 2021
Background: Patients with heart failure (HF) are often cared for by non-cardiologists. The implications are unknown. Methods: In a nationwide HF cohort with reduced ejection fraction (HFrEF), we compared demographics, clinical characteristics, guideline ...
Thorvaldsen, Tonje, Lund L. H., Kapelios C. J., Hage, C,, Dahlstrom, U, Lund, LH, Savarese, G,, Benson, Lina, Dahlstrom U., Kapelios, Chris J., Benson, Lina,, Lund, Lars H.,, Dahlström, Ulf, Canepa, Marco,, Canepa, Marco, Canepa M., Savarese, Gianluigi, Canepa, M, Thorvaldsen, Tonje,, Thorvaldsen T., Benson L., Savarese G., Thorvaldsen, T,, Lund, Lars H., Kapelios, Chris J.,, Kapelios, CJ, Hage, Camilla, Hage C., Dahlström, Ulf,, Savarese, Gianluigi,, Hage, Camilla,, Benson, L,, Tonje Thorvaldsen, Ulf Dahlström, Marco Canepa, Gianluigi Savarese, Lars H. Lund, Camilla Hage, Chris J. Kapelios, Lina Benson   +39 more
core   +1 more source

Phase Separation of TRIM21 Modulates PTPN14 Stability to Drive Flow‐Dependent Endothelial Activation and Atherogenesis

Advanced Science, EarlyView.
Disturbed flow promotes the formation of TRIM21‐rich biomolecular droplets, which concentrate TRIM21 and PTPN14 and facilitate their SPRY‐FERM interaction (illustrated by the TRIM21 D355‐PTPN14 R132 salt bridge). This condensate‐driven proximity enables TRIM21 to catalyze K48‐linked polyubiquitination of PTPN14 at lysine 956, leading to proteasome ...
Xue He, Qiannan Ma, Xue Wang, Jiaxu Mang, Chufeng Li, Bingjun Wu, Liu Yao, Yequn Chen, Qiankun Bao, Yi Zhu, Jinlong He   +10 more
wiley   +1 more source

The Cardiovascular Care of the Pediatric Athlete.

Sports cardiology broadly encompasses the cardiovascular care of individuals who place a high premium on habitual exercise, sports performance, and/or sports competition. Some of the essential aspects within sports cardiology include the preparticipation
Shafer, K., Hsu, J., Edelson, J.B., Kim, J.H., Brothers, J.A., Burns, K., Husaini, M., Danielian, A., Etheridge, S., Martinez, M.W., Phelan, D.M., Molossi, S., Snyder, C., Friedman, E.M., Baggish, A.L., Levine, B.D., Dean, P.N., Chung, E.H., American College of Cardiology Sports & Exercise Cardiology Council, Husaini, Mustafa, Molossi, Silvana, Chung, Eugene H, Etheridge, Susan, Snyder, Chris, Shafer, Keri, Burns, Kristin, Edelson, Jonathan B, Martinez, Matthew W, Kim, Jonathan H, Hsu, Jeff, Levine, Benjamin D, Phelan, Dermot M, Friedman, Eli M, Baggish, Aaron L, Danielian, Alfred, Dean, Peter N, Brothers, Julie A   +36 more
core   +1 more source

Serial Molecular‐Microstructural Multimodal Intravascular Imaging of Atherosclerotic Plaques in Mice

Advanced Science, EarlyView.
A novel longitudinal molecular and microstructural intravascular imaging approach is developed to study murine atherosclerosis. The technique combines a unique surgical model with a miniaturized multimodal device to detect macrophage activity and lipid simultaneously.
Jiawen Li, Joanne T. M. Tan, Lei Xiang, Jiandi Liu, Ayla Hoogendoorn, Victoria A. Nankivell, Lauren Sandeman, Richard Le, Rouyan Chen, Robert A. McLaughlin, Peter J. Psaltis, Johan W. Verjans, Christina A. Bursill   +12 more
wiley   +1 more source

Enhancing paediatric and congenital cardiology e-learning postgraduate education: insights from the Association for European Paediatric and Congenital Cardiology directed webinar series / [PDF]

bstract Objective: A series of webinars covering widespread knowledge on paediatric cardiology and cardiac surgery topics was initiated by Association for European Paediatric and Congenital Cardiology, serving towards preparation for the Association for ...
Bosschers, Linda,, Mcmahon, Colin J., Piccinelli, Enrico, Pitkanen-Argillander, Olli,, Michel-Behnke, Ina, Michel-Behnke, Ina,, Heying, Ruth, Milanesi, Ornella, Heying, Ruth,, Albert-Brotons, Dimpna C.,, Milanesi, Ornella,, Voges, Inga,, Piccinelli, Enrico,, Albert-Brotons, Dimpna C., Sendžikaitė, Skaistė,, Bosschers, Linda, Sendzikaite, Skaiste, Voges, Inga, Mcmahon, Colin J.,, Pitkanen-Argillander, Olli   +19 more
core   +2 more sources

SerpinA3 is an Endogenous TGF‐β Receptor Antagonist that Attenuates Cardiac Fibroblast Activation and Fibrotic Remodeling

Advanced Science, EarlyView.
SerpinA3 acts as an endogenous TGF‐β receptor antagonist that binds to the extracellular domain of TGFR‐1, thereby preventing TGFR‐1–TGFR‐2 complex formation. This receptor‐level blockade suppresses TGF‐β/Smad2/3 signaling, attenuates cardiac fibroblast activation, and extracellular matrix deposition, and ultimately alleviates pressure overload–induced
Hui Wang, Jieyu Cui, Chunlu Huang, Wanyi Guo, Tong Liu, Yi Zhu, Shuai Shao, Kangyin Chen, Jinlong He, Qiankun Bao   +9 more
wiley   +1 more source

Macrophage PARP7 Alleviates Septic Cardiomyopathy by Interacting With TBK1 and Suppressing TBK1‐Driven Inflammatory Response

Advanced Science, EarlyView.
In septic cardiomyopathy, PARP7 directly binds TBK1 and mediates its ADP‐ribosylation, thereby repressing TBK1‐driven proinflammatory signaling in macrophages. ABSTRACT Septic cardiomyopathy is a life‐threatening complication of sepsis, and an uncontrolled inflammatory response represents a key pathogenic mechanism. PARP7 negatively regulates the IFN‐I
Jibo Han, Lintao Wang, Xin Zhong, Shenggang Zhao, Huihui Xie, Xue Han, Liming Lin, Yiting Lyu, Ke Xu, Jiajun Xu, Xiaowen Shi   +10 more
wiley   +1 more source

Back to the future? Developments in postgraduate cardiology training

, 2008
Postgraduate medical training has undergone extensive reform in recent times. This article outlines the current state of affairs and possible future developments in cardiology specialist ...
Kelly DJ, Kabir T, Cunnington MS, Gale CP, Simpson H   +4 more
core   +3 more sources

Mitochondria‐Targeted Multimodal Nanotherapeutics Suppress Oxidized mtDNA‐Driven Inflammation at the Source

Advanced Science, EarlyView.
Ox‐mtDNA fragments escaping from mitochondria drive robust inflammatory responses. A targeted nanoplatform simultaneously inhibits mitochondrial FEN1‐mediated mtDNA cleavage and scavenges ROS, preventing the generation of immunogenic Ox‐mtDNA fragments. The released SeNPs further promote autophagic clearance of cytosolic mtDNA. Consequently, cGAS‐STING,
Wen‐Ling Li, Juan Cao, Yu‐Lin Wang, Yu‐Han Fan, Jia‐Qi Xu, Xian Wu Cheng, Lei Xing, Hu‐Lin Jiang   +7 more
wiley   +1 more source

ATP-P2X7R-NLRP3 Axis as a Unifying Mechanism of ATP-Induced Cell Death in Degenerative Bone and Cardiovascular Diseases

Journal of Inflammation Research
Jingjing Zhang,1– 3,* Linzhu Li,4,* Qianwen Guo,5 Xuesong Liu,6 Qian Qiao,1– 3 Xuerui Ye,1– 3 Hongyang Ding,1– 3 Yi Liu,7 Kaikai Wang,8 Haoling Zhang,9 Lu Cheng1– 3 1Fuwai Yunnan Hospital, Chinese Academy of Medical Sciences, Affiliated ...
Zhang J, Li L, Guo Q, Liu X, Qiao Q, Ye X, Ding H, Liu Y, Wang K, Zhang H, Cheng L   +10 more
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