Results 51 to 60 of about 721,847 (303)

ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells

Advanced Science, EarlyView.
With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao, Shannon Erhardt, Li Tang, Xiaotong Chen, Stephen M Farmer, Zixiu Cheng, Wen Chen, Ella Ziyuan Lu, Kihan Sung, Chang‐Ru Tsai, Mingjie Zheng, Sheng Zhang, Yang Liu, Jianxin Wang, Min Li, James F Martin, Jun Wang   +16 more
wiley   +1 more source

How did the updated 2019 european society of cardiology/european atherosclerosis society risk categorization for patients with diabetes affect the risk perception and lipid goals, a simulated analysis of real-life data from EPHESUS study [PDF]

, 1989
Background: The recent 2019 European Society of Cardiology/European Atherosclerosis Society practice guidelines introduced a new risk categorization for patients with diabetes. We aimed to compare the implications of the 2016 and 2019 European Society of
Mert, Kadir Uğur, Çil, Cem, Demirhan, Funda, Başaran, Özcan, Çelik, Oğuzhan, Doğan, Volkan, Özlek, Bülent, Özlek, Eda, Biteker, Murat, İnci, Sinan   +9 more
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The ePortfolio in UK cardiology training: time for a new digital platform?

, 2021
The UK cardiology specialist training programme utilises the National Health Service (NHS) e-Portfolio to ensure adequate progression is being made during a trainees’ career.
Obeidat, Mohammed, Davis, Gershan, Elamin, Ahmed, Obeidat, Mohammed; id_orcid   +3 more
core   +1 more source

A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain

Advanced Science, EarlyView.
Zhang et al. uncover a novel central mechanism for persistent muscle pain, in which TRPA1 sensitization in MeV proprioceptive neurons enhances somatic secretion. This, in turn, disinhibits descending pain control from neighboring noradrenergic locus coeruleus neurons via local GABAergic circuits, thereby promoting inflammatory muscle pain.
Xiaoyu Zhang, Jiale Yang, Xi Wu, Jie Li, Fujian Lu, Yiman Li, Xingyu Du, Rong Huang, Jamila Asgar, Jing Wang, Ke Ren, Feipeng Zhu, Changhe Wang, Yehua Gan, Feng Wei, Zhuan Zhou   +15 more
wiley   +1 more source

DOT1L Drives Endothelial‐to‐Mesenchymal Transition and Fibrotic Vascular Remodeling via H3K79 Methylation

Advanced Science, EarlyView.
DOT1L as a central epigenetic regulator of EndoMT and pulmonary fibrosis. Acting as an early epigenetic switch, it translates TGFβ–SMAD signaling into H3K79me2‐mediated chromatin remodeling, selectively activates fibrosis‐related genes, and primes ECs for rapid mesenchymal transition.
Yaofeng Wang, Xing Peng, Jingjing Chen, Yun Zhang, Tinghong Zhang, Jingyuan Zhang, Jiaying Fan, Hui Zheng, Qiaoyuan Liu, Zhimin Song, Zhan‐Peng Huang, Shu Meng   +11 more
wiley   +1 more source

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

Oral Bioinspired Peroxisome‐Engineered Probiotics for Modulating Gut Microbiota Homeostasis and Alleviating Cardiac Chemotherapy Toxicity

Advanced Science, EarlyView.
This study developed an oral bioinspired peroxisome‐engineered probiotic (BPEP) by anchoring lipid‐encapsulated ruthenium nanozymes onto Escherichia coli Nissle 1917, utilizing probiotics to deliver nanozymes to the intestinal barrier for reactive oxygen species/reactive nitrogen species elimination, tight junction restoration, and gut microbiota ...
Shuyu Wang, Xiaowan Fan, Chao Zhang, Shuai Han, Yike Guo, Yuchen Wang, Wei Wang, Junyue Xing, Ying Liu, Wei Jiang, Xiaoying Chen   +10 more
wiley   +1 more source

Highlights of the 2009 scientific sessions of the European Society of Cardiology [PDF]

, 2009
Copyright © 2009 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.The annual congress of the European Society of Cardiology (ESC) was held in Barcelona, Spain, August 29 to September 2, 2009.
Carlo Di Mario, Vardas, Panos E, Petros Nihoyannopoulos, Fausto J. Pinto, Raphael Rosenhek, Filippatos, Gerasimos, Barbara Casadei, Joep Perk, Di Mario, C., Bax, Jeroen J, Frank Rademakers, Fox, Keith A.A., Vardas, Panos E., Fox, Keith A A, Vardas, PE, Pinto, FJ, Keith A. A. Fox, Rademakers, F, Fagard, R, Panos E. Vardas, Rademakers, Frank, Perk, Joep, Bax, JJ, Metra, Marco, Filippatos, G, Gerasimos Filippatos, Perk, J, Di Mario, Carlo, Fox, Keith A. A., Rosenhek, Raphael, Fox, Keith A, Ferrari, Roberto, Di Mario, C, Casadei, Barbara, Nihoyannopoulos, P, Perk, Joep,, Nihoyannopoulos, Petros, Robert Fagard, Pinto, Fausto J, Bax, Jeroen J., Jeroen J. Bax, Fagard, Robert, Marco Metra, Fox, KA, Metra, M, Ferrari, R, Pinto, Fausto J., Rosenhek, R, Casadei, B   +48 more
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Recommendations and Associated Levels of Evidence for Statin Use in Primary Prevention of Cardiovascular Disease: A Comparison at Population Level of the American Heart Association/American College of Cardiology/Multisociety, US Preventive Services Task Force, Department of Veterans Affairs/Department of Defense, Canadian Cardiovascular Society, and European Society of Cardiology/European Atherosclerosis Society Clinical Practice Guidelines.

, 2021
BACKGROUND Despite using identical evidence to support practice guidelines for lipid-lowering treatment in primary prevention of cardiovascular disease (CVD), it is unclear to what extent the 2018 American Heart Association/American College of ...
Kavousi, Maryam, Ikram, M Arfan, Leening, Maarten J G, Ikram, M Kamran, Deckers, Jaap W, Deckers, Jaap W., Leening, Maarten J. G., Ikram, M. Arfan, Leening, Maarten J. G.; id_orcid, Franco, Oscar H., Greenland, Philip, Ikram, M. Kamran, Pavlović, Jelena   +12 more
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O‐GlcNAcylated TAP1 Impairs Antigen Presentation and Promotes Immune Evasion in Bladder Cancer

Advanced Science, EarlyView.
This article unveils a critical mechanism of immune evasion in bladder cancer, which the O‐GlcNAc modification of TAP1 disrupts antigen presentation. This modification triggers HLA‐A degradation, shielding tumor cells from CD8+ T cell attack. The findings highlight targeting this pathway as a promising therapeutic avenue to sensitize tumors to ...
Jinpeng Wu, Xueting Ren, Zhen Zhai, Lu Wang, Liang Liang, Zengqi Tan, Jiazhen Zhao, Yuxuan Han, Yuhan Li, Feng Guan, Xiang Li   +10 more
wiley   +1 more source