Results 71 to 80 of about 123,173 (290)

Circulating leukocyte telomere length is highly heritable among families of Arab descent [PDF]

, 2012
Background Telomere length, an indicator of ageing and longevity, has been correlated with several biomarkers of cardiometabolic disease in both Arab children and adults.
AS Al-Rethaiaa, Assim A Alfadda, C Bischoff, ES Epel, George P Chrousos, Greg C Gibson, J Lin, K Nordfjall, KA Mather, Khalid M Alkharfy, L Kazubowska, LS Wong, Majed S Alokail, MM Al-Nozha, Nasser M Al-Daghri, NM Al-Daghri, NM Al-Daghri, NM Al-Daghri, NM Al-Daghri, NM Al-Daghri, NM Al-Daghri, NM Bawazeer, O Al-Attas, Omar S Al-Attas, OS Al-Attas, OT Njajou, Philip McTernan, RM Cawthon, Shaun B Sabico, TJ Cole, WS Browner   +30 more
core   +3 more sources

3D Bioprinted Fat‐Myocardium Model Unravels the Role of Adipocyte Hypertrophy in Atrial Dysfunction

Advanced Science, EarlyView.
A human‐derived 3D bioprinted fat–myocardium model is developed to investigate how adipocyte hypertrophy drives atrial dysfunction in obesity. Palmitate‐induced adipocyte hypertrophy promotes adipose dysfunction that impairs atrial cardiomyocyte metabolism and electrophysiology through both paracrine and direct interactions. This platform recapitulates
Lara Ece Celebi, Pinar Zorlutuna
wiley   +1 more source

The effect of lipid-lowering therapy on lipid-related residual risk factors: a prospective study

Lipids in Health and Disease
Background Remnant cholesterol (RC) and nonhigh-density lipoprotein cholesterol (nonHDL-C) are key risk factors for atherosclerotic cardiovascular disease (ASCVD), with apolipoprotein B (apoB) and lipoprotein(a) [Lp(a)] also contributing to its residual ...
Zhifan Li, Yanan Gao, Qianhong Lu, Zheng Yin, Shuang Zhang, Wenjia Zhang, Yonggang Sui, Yanlu Xu, Jianjun Li, Kefei Dou, Jie Qian, Hong Qiu, Naqiong Wu   +12 more
doaj   +1 more source

Caspase‐3/GSDME‐Mediated Trophoblast Pyroptosis and Reciprocal Macrophage Polarization Contribute to Inflammation in Early‐Onset Preeclampsia

Advanced Science, EarlyView.
In trophoblast cells, T/S (TNFα + SM164) activated caspase‐3, which cleaved GSDME to switch apoptosis to pyroptosis, causing cell swelling, membrane rupture, and release of LDH, HMGB1, IL‐1β and IL‐18. These cytokines induced pro‐inflammatory macrophage polarization, which in turn reinforced pyroptotic signaling in trophoblasts, amplifying systemic ...
Baoying Huang, Weinan Deng, Shilei Bi, Yifan Wang, Zhaowei Tu, Lijun Huang, Lili Du, Lizi Zhang, Zhoushan Feng, Wei Sun, Tengfei Liu, Julia Kzhyshkowska, Haibin Wang, Jingsi Chen, Dunjin Chen, Shuang Zhang   +15 more
wiley   +1 more source

Effect of changes in the triglyceride-glucose index on atherogenic lipid profiles in coronary artery disease patients receiving lipid-lowering therapy: a prospective cohort study

Cardiovascular Diabetology
Background Insulin resistance (IR) is a key driver of cardiovascular disease. The triglyceride-glucose (TyG) index, derived from fasting triglyceride and glucose levels, has been proposed as a surrogate marker of IR.
Zhi-Fan Li, Zheng Yin, Xi Li, Meng-Ying Lu, Wen-Jia Zhang, Fang Luo, Yan-Lu Xu, Jian-Jun Li, Ke-Fei Dou, Xiao Wang, Hong Qiu, Na-Qiong Wu   +11 more
doaj   +1 more source

Comparison of Estimated LDL Cholesterol Equations with Direct Measurement in Patients with Angiographically Confirmed Coronary Artery Disease

Journal of Cardiovascular Development and Disease, 2022
Background and aims: Our goals in the study were to (1) quantify the discordance in LDL-C levels between equations (the Friedewald, Sampson, and Martin/Hopkins equations) and compare them with direct LDL-C (dLDL-C); and (2) explore the proportion of ...
Boqun Shi, Hao-Yu Wang, Dong Yin, Chenggang Zhu, Lei Feng, Hongjian Wang, Lei Jia, Rui Fu, Chenxi Song, Zhou Zhou, Yahui Lin, Weihua Song, Ke-Fei Dou   +12 more
doaj   +1 more source

Multi‐Tissue Genetic Regulation of RNA Editing in Pigs

Advanced Science, EarlyView.
This study presents the first multi‐tissue map of RNA editing and its genetic regulation in pigs. By integrating RNA editing profiles, edQTL mapping, GWAS, and cross‐species comparisons, this work establishes RNA editing as a distinct regulatory layer linking genetic variation to complex traits, highlighting its functional and evolutionary significance.
Xiangchun Pan, Wentao Gong, Xiaodian Cai, Jinyan Teng, Jiali Cai, Haonan Zeng, Wondossen Ayalew, Qingpeng Shen, Zhanming Zhong, Yifei Wang, Wenjing Zhang, Yuhan Tian, Dantong Xu, Yahui Gao, Hongwei Yin, Yuebo Zhang, Jiahui Hou, Tianru Zhou, Jiaqi Li, Lingzhao Fang, Xiaolong Yuan, Zhe Zhang   +21 more
wiley   +1 more source

Synergistic effect of the commonest residual risk factors, remnant cholesterol, lipoprotein(a), and inflammation, on prognosis of statin-treated patients with chronic coronary syndrome

Journal of Translational Medicine, 2022
Background Currently, remnant cholesterol (RC), lipoprotein(a) [Lp(a)], and inflammation are considered the principal residual cardiovascular risk (RCVR) factors.
Hui-Hui Liu, Yuan-Lin Guo, Cheng-Gang Zhu, Na-Qiong Wu, Ying Gao, Rui-Xia Xu, Qian Dong, Jie Qian, Ke-Fei Dou, Jian-Jun Li   +9 more
doaj   +1 more source

Recent Advances in Understanding the Role of IKKβ in Cardiometabolic Diseases

Frontiers in Cardiovascular Medicine, 2021
Cardiometabolic diseases, including cardiovascular disease, obesity, and diabetes, are the leading cause of mortality and morbidity worldwide. Cardiometabolic diseases are associated with many overlapping metabolic syndromes such as hypertension ...
Rebecca Hernandez, Changcheng Zhou
doaj   +1 more source

Relationship between blood pressure values, depressive symptoms and cardiovascular outcomes in patients with cardiometabolic disease [PDF]

, 2016
We studied joint effect of blood pressure-BP and depression on risk of major adverse cardiovascular outcome in patients with existing cardiometabolic disease. A cohort of 35537 patients with coronary heart disease, diabetes or stroke underwent depression
Barry, Sarah J.E., Cavanagh, Jonathan, Der, Geoff, Jani, Bhautesh Dinesh, Mair, Frances S., Sattar, Naveed   +5 more
core   +2 more sources