Results 51 to 60 of about 10,604,379 (306)

Genetic predictors of lifelong medication-use patterns in cardiometabolic diseases

Nature Medicine, 2023
Little is known about the genetic determinants of medication use in preventing cardiometabolic diseases. Using the Finnish nationwide drug purchase registry with follow-up since 1995, we performed genome-wide association analyses of longitudinal patterns
T. Kiiskinen, P. Helkkula, Kristi Krebs, J. Karjalainen, E. Saarentaus, N. Mars, Arto A Lehisto, Wei Zhou, M. Cordioli, S. Jukarainen, Joel T. Rämö, J. Mehtonen, K. Veerapen, Markus Räsänen, S. Ruotsalainen, Mutaamba Maasha, T. Niiranen, T. Tuomi, V. Salomaa, M. Kurki, M. Pirinen, A. Palotie, M. Daly, A. Ganna, A. Havulinna, L. Milani, S. Ripatti   +26 more
semanticscholar   +1 more source

High triglyceride-glucose index and stress hyperglycemia ratio as predictors of adverse cardiac events in patients with coronary chronic total occlusion: a large-scale prospective cohort study

Cardiovascular Diabetology, 2023
Background The triglyceride-glucose (TyG) index and the stress hyperglycaemia ratio (SHR) are both positively associated with cardiovascular (CV) risk in patients with coronary heart disease.
Yanjun Song, Kongyong Cui, Min Yang, Chenxi Song, Dong Yin, Qiuting Dong, Ying Gao, Kefei Dou   +7 more
doaj   +1 more source

Uric Acid Levels, Number of Standard Modifiable Cardiovascular Risk Factors, and Prognosis in Patients With Coronary Artery Disease: A Large Cohort Study in Asia

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Serum uric acid (UA) is correlated closely with traditional cardiovascular risk factors, which might interfere with the action of UA, in patients with coronary artery disease.
Kongyong Cui, Yanjun Song, Dong Yin, Weihua Song, Hongjian Wang, Chenggang Zhu, Lei Feng, Rui Fu, Lei Jia, Ye Lu, Dong Zhang, Chenxi Song, Yuejin Yang, Qiuting Dong, Kefei Dou   +14 more
doaj   +1 more source

Magnesium Deficiency and Cardiometabolic Disease

Nutrients, 2023
Magnesium (Mg2+) has many physiological functions within the body. These include important roles in maintaining cardiovascular functioning, where it contributes to the regulation of cardiac excitation–contraction coupling, endothelial functioning and haemostasis.
Remi Fritzen, Amy Davies, Miriam Veenhuizen, Matthew Campbell, Samantha J. Pitt, Ramzi A. Ajjan, Alan J. Stewart   +6 more
openaire   +3 more sources

The oral-gut microbiota axis: a link in cardiometabolic diseases

npj Biofilms and Microbiomes
The oral-gut microbiota axis plays a crucial role in cardiometabolic health. This review explores the interactions between these microbiomes through enteric, hematogenous, and immune pathways, resulting in disruptions in microbial balance and metabolic ...
Qian Xu, Wenting Wang, Yiwen Li, Jing Cui, Mengmeng Zhu, Yanfei Liu, Yue Liu   +6 more
semanticscholar   +1 more source

Lipids Metabolism and Cardiometabolic Diseases

International Journal of Molecular Sciences, 2023
Cardiometabolic diseases (CMD) remains the major cause of morbidity and mortality in Western countries, with a marked increased in the last years [...]
Melania Gaggini, Cristina Vassalle
openaire   +3 more sources

Vitamin D Enhancement of Adipose Biology: Implications on Obesity-Associated Cardiometabolic Diseases

Nutrients
Vitamin D is activated into 1α,25(OH)2D through two hydroxylation steps that are primarily catalyzed by 25-hydroxylase in the liver and 1α-hydroxylase in the kidneys.
Mi-Jeong Lee
semanticscholar   +1 more source

Human brown adipose tissue is not enough to combat cardiometabolic diseases

Journal of Clinical Investigation, 2023
Brown adipose tissue (BAT) stands out as the sole tissue able to substantially expend energy by leveraging uncoupling protein 1 (UCP1) to increase proton permeability through the inner mitochondrial membrane.
A. Carpentier, D. Blondin
semanticscholar   +1 more source

In the heart of adipobiology: cardiometabolic disease

Biomedical Reviews, 2009
Published on 1 December 1994 issue of Nature, the Jeffrey Friedman's discovery "gave leptin in the beginning" of the endocrine saga of adipose tissue. Onwards, studies on this tissue have enjoyed an explosive growth that conceptualized a novel field of research, adipobiology.
Chaldakov GN, Fiore M, Tonchev AB, Rancic G, Hristova MG, Tuncel N, Kostov DD, Nikolova V, Bojanic V, Aloe L   +9 more
openaire   +2 more sources

Liver fat as risk factor of hepatic and cardiometabolic diseases

Obesity Reviews, 2023
Non‐alcoholic fatty liver disease (NAFLD) is a disorder characterized by excessive accumulation of fat in the liver that can progress to liver inflammation (non‐alcoholic steatohepatitis [NASH]), liver fibrosis, and cirrhosis.
M. Demir, S. Bornstein, C. Mantzoros, Nikolaos Perakakis   +3 more
semanticscholar   +1 more source