Results 71 to 80 of about 10,604,379 (306)

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source

New Insights into Endothelial Dysfunction in Cardiometabolic Diseases: Potential Mechanisms and Clinical Implications

International Journal of Molecular Sciences
The endothelium is a monocellular layer covering the inner surface of blood vessels. It maintains vascular homeostasis regulating vascular tone and permeability and exerts anti-inflammatory, antioxidant, anti-proliferative, and anti-thrombotic functions.
Giovanna Gallo, Carmine Savoia
semanticscholar   +1 more source

Factors Associated With the Rising Trend in Self‐Reported Cognitive Disability Among U.S. Adults Aged 18–39 From 2013–2024

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Building on our prior Behavioral Risk Factor Surveillance System analysis identifying adults aged 18–39 as the primary driver of the national increase in self‐reported cognitive disability, we examined factors associated with this rise using 2013–2024 U.S. BRFSS data. Methods We analyzed U.S.
Adam de Havenon, Ka‐Ho Wong, Mirriam Mananah, Christopher D. Anderson, Ada Fenick, Amy Arnsten, Arman Fesharaki‐Zadeh, James C. McPartland, Mary L. Adams, Kevin N. Sheth   +9 more
wiley   +1 more source

Subclassification of obesity for precision prediction of cardiometabolic diseases

Nature Medicine
Obesity and cardiometabolic disease often, but not always, coincide. Distinguishing subpopulations within which cardiometabolic risk diverges from the risk expected for a given body mass index (BMI) may facilitate precision prevention of cardiometabolic ...
Daniel E. Coral, Femke Smit, A. Farzaneh, A. Gieswinkel, J. F. Tajes, Thomas Sparsø, Carl Delfin, Pierre Bauvin, Kan Wang, M. Temprosa, D. De Cock, Jordi Blanch, J. Fernández-Real, R. Ramos, M. K. Ikram, M. Gomez, M. Kavousi, M. Panova-Noeva, Philipp S. Wild, Carla J. H. van der Kallen, M. Adriaens, M. V. van Greevenbroek, Ilja Arts, C. L. le Roux, F. Ahmadizar, T. Frayling, G. Giordano, E. Pearson, P. W. Franks   +28 more
semanticscholar   +1 more source

Dietary Fibers and Cardiometabolic Diseases

International Journal of Molecular Sciences, 2012
The high prevalence of cardiovascular disease (CVD) is largely attributable to the contemporary lifestyle that is often sedentary and includes a diet high in saturated fats and sugars and low ingestion of polyunsaturated fatty acids (PUFAs), fruit, vegetables, and fiber.
RICCIONI, Graziano, Sblendorio V, Gemello E, Di Bello B, Scotti L, Cusenza S, D'ORAZIO, Nicolantonio   +6 more
openaire   +3 more sources

Troponin T and Neurofilament Light Chain Levels as Complementary Biomarkers of Disease Accumulation and Aggressiveness in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a clinically heterogeneous neurodegenerative disease requiring reliable biomarkers to improve patient stratification and trial design. While serum neurofilament light chain (sNfL) reflects neuroaxonal stress and disease aggressiveness, troponin T (TnT) may capture complementary aspects of ...
Julia Sellin, Sofia Waldorf, Janina von der Gablentz, Torsten Grehl, Huelya Nazlican, Thomas Meyer, Julian Grosskreutz, Patrick Weydt, Sarah Bernsen   +8 more
wiley   +1 more source

Time Trends of Etiology, Treatment, and Long-Term Outcomes Among Patients with Left Ventricular Thrombus

Reviews in Cardiovascular Medicine, 2023
Background: Recommendations for drug treatment of left ventricular thrombus (LVT) are based on the ST-segment elevation myocardial infarction (STEMI) guidelines; however, the etiology of LVT has changed.
Boqun Shi, Yanjun Song, Lie Ma, Xieraili Tiemuerniyazi, Jinpeng Liu, Rui Zhang, Chenxi Song, Lei Jia, Dong Yin, Hongjian Wang, Wei Feng, Weihua Song, Ke-Fei Dou   +12 more
doaj   +1 more source

Emerging Roles and Mechanism of m6A Methylation in Cardiometabolic Diseases

Cells, 2022
Cardiometabolic diseases (CMDs) are currently the leading cause of death and disability worldwide, and their underlying regulatory mechanisms remain largely unknown.
Zujie Xu, Bin Lv, Ying Qin, Bing Zhang
semanticscholar   +1 more source

Obesity Subtypes and Longitudinal Trajectories of Function Over Seven Years of Follow‐Up: Data From the Multicenter Osteoarthritis Study

Arthritis Care &Research, EarlyView.
Objective Obesity, defined by body mass index (BMI) ≥30 kg/m2, is a risk factor for functional limitations in people with knee osteoarthritis (OA). However, function varies among such individuals. Our objective was to evaluate the implications of obesity subtypes on longitudinal patterns of physical functioning in people with or at risk for knee OA ...
Kristine Godziuk, Sarah Tilley, Michael LaValley, Michael C. Nevitt, Cora E. Lewis, James C. Torner, Tuhina Neogi, for the Multicenter Osteoarthritis Study Group   +7 more
wiley   +1 more source

The effect of lipid-lowering therapy on lipid-related residual risk factors: a prospective study

Lipids in Health and Disease
Background Remnant cholesterol (RC) and nonhigh-density lipoprotein cholesterol (nonHDL-C) are key risk factors for atherosclerotic cardiovascular disease (ASCVD), with apolipoprotein B (apoB) and lipoprotein(a) [Lp(a)] also contributing to its residual ...
Zhifan Li, Yanan Gao, Qianhong Lu, Zheng Yin, Shuang Zhang, Wenjia Zhang, Yonggang Sui, Yanlu Xu, Jianjun Li, Kefei Dou, Jie Qian, Hong Qiu, Naqiong Wu   +12 more
doaj   +1 more source