Results 31 to 40 of about 10,604,379 (306)
The incretin system and cardiometabolic disease [PDF]
Canadian Journal of Cardiology, 2010 Rates of type 2 diabetes, obesity and their associated detrimental cardiovascular effects are rapidly increasing. Despite the availability of several treatment options for type 2 diabetes and the use of intensive regimens combining several antidiabetic drugs, less than one-half of all patients reach a target glycosylated hemoglobin level of less than 7%
Paul E, Szmitko +2 more
openaire +2 more sources
Reviews in Cardiovascular Medicine, 2021 The aim of our study is to evaluate the association of rotational atherectomy (RA) operation procedural indices and baseline lipid parameters with the prognosis of the patients with severe coronary calcification who underwent RA.
Shuang Zhang +6 more
doaj +1 more source
The Na+/K+-ATPase: A potential therapeutic target in cardiometabolic diseases
Frontiers in Endocrinology, 2023 Cardiometabolic diseases (CMD) are a direct consequence of modern living and contribute to the development of multisystem diseases such as cardiovascular diseases and diabetes mellitus (DM). CMD has reached epidemic proportions worldwide.
M. Obradović +5 more
semanticscholar +1 more source
Hypertension and cardiometabolic disease
Frontiers in Bioscience, 2018 Hypertension has a central role in cardiometabolic disease and is usually associated with metabolic disorders, such as insulin resistance, obesity, and dyslipidemia. Hyperinsulinemia may increase cardiovascular (CV) risk through its promotion of hypertension, which is possibly a result of chronic enhancement of sympathetic nervous system activity ...
Ivan, Tasic, Dragan, Lovic
openaire +2 more sources
Nature Genetics, 2022 Cardiometabolic diseases are the leading cause of death worldwide. Despite a known genetic component, our understanding of these diseases remains incomplete. Here, we analyzed the contribution of rare variants to 57 diseases and 26 cardiometabolic traits,
S. Jurgens +70 more
semanticscholar +1 more source
Targeting the vasculature in cardiometabolic disease
Journal of Clinical Investigation, 2022 Obesity has reached epidemic proportions and is a major contributor to insulin resistance (IR) and type 2 diabetes (T2D). Importantly, IR and T2D substantially increase the risk of cardiovascular (CV) disease. Although there are successful approaches to maintain glycemic control, there continue to be increased CV morbidity and mortality associated with
Nabil E. Boutagy +2 more
openaire +3 more sources
Lipids in Health and Disease, 2022 Background The risk of liver fibrosis in non-alcoholic fatty liver disease (NAFLD) can be easily evaluated by noninvasive scoring systems, of which the NAFLD fibrosis score (NFS) is the most commonly used.
Jia Peng +10 more
doaj +1 more source
mAbs, 2022 An in-house antibody generation campaign identified a diverse, high affinity set of anti-interleukin-11 (IL-11) monoclonal antibodies (mAbs) to enable successful development of novel, custom ultra-sensitive target engagement assays for detection of “free”
Maria Myzithras +12 more
doaj +1 more source
Epigenetic processing in cardiometabolic disease [PDF]
Atherosclerosis, 2019 Albeit a consistent body of evidence supports the notion that genes influence cardiometabolic features and outcomes, the "non-genetic regulation" of this process is gaining increasing attention. Plastic chemical changes of DNA/histone complexes - known as epigenetic changes - critically determine gene activity by rapidly modifying chromatin ...
Costantino, Sarah +3 more
openaire +4 more sources
Uric acid and cardiometabolic diseases [PDF]
Clinical Hypertension, 2020 AbstractHyperuricemia, which has been considered as a cause of gout and nephrolithiasis has recently been suggested to be associated with hypertension, coronary heart disease, heart failure, atrial fibrillation, insulin resistance, and nonalcoholic fatty liver disease.
Seung Jae Lee +2 more
openaire +3 more sources