Results 11 to 20 of about 2,327,467 (213)
Calpain and Cardiometabolic Diseases
International Journal of Molecular Sciences, 2023 Calpain is defined as a member of the superfamily of cysteine proteases possessing the CysPC motif within the gene. Calpain-1 and -2, which are categorized as conventional isozymes, execute limited proteolysis in a calcium-dependent fashion. Accordingly,
Takuro Miyazaki
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Lipids Metabolism and Cardiometabolic Diseases
International Journal of Molecular Sciences, 2023 Cardiometabolic diseases (CMD) remains the major cause of morbidity and mortality in Western countries, with a marked increased in the last years [...
Cristina Vassalle +3 more
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Mitochondrial Sirtuins in cardiometabolic diseases
Clinical Science, 2017 Mitochondria are heterogeneous and essentially contribute to cellular functions and tissue homeostasis. Mitochondrial dysfunction compromises overall cell functioning, tissue damage, and diseases.
Xiao-Feng Chen +3 more
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Potential Involvement of LncRNAs in Cardiometabolic Diseases [PDF]
, 2023 Characterized by cardiovascular disease and diabetes, cardiometabolic diseases are a major cause of mortality around the world. As such, there is an urgent need to understand the pathogenesis of cardiometabolic diseases. Increasing evidence suggests that
Mirolyuba Ilieva +3 more
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Coronavirus Disease 2019 and Cardiometabolic Disease
Cardiology in Review, 2021 Cardiometabolic disease describes a combination of metabolic abnormalities that increases the risk of type 2 diabetes and cardiovascular diseases, including pathological changes such as insulin resistance, hyperglycemia, dyslipidemia, abdominal obesity, and hypertension, and environmental risk factors such as smoking, sedentary lifestyle, poor diet ...
Chan W, Kim +2 more
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Circulating Microbiota in Cardiometabolic Disease
Frontiers in Cellular and Infection Microbiology, 2022 The rapid expansion of microbiota research has significantly advanced our understanding of the complex interactions between gut microbiota and cardiovascular, metabolic, and renal system regulation. Low-grade chronic inflammation has long been implicated as one of the key mechanisms underlying cardiometabolic disease risk and progression, even before ...
Keiichi Sumida +10 more
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Recent Advances in Understanding the Role of IKKβ in Cardiometabolic Diseases. [PDF]
, 2021 Cardiometabolic diseases, including cardiovascular disease, obesity, and diabetes, are the leading cause of mortality and morbidity worldwide. Cardiometabolic diseases are associated with many overlapping metabolic syndromes such as hypertension ...
Hernandez, Rebecca, Zhou, Changcheng
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Inflammatory markers and cardiometabolic diseases [PDF]
Acta Clinica Belgica, 2015 A growing body of evidence emerges that obesity, metabolic syndrome, type 2 diabetes and cardiovascular disease are intimately related to chronic inflammation.A narrative review summarizing the most recent data of the literature describing the pathological implications of inflammation in obese patients with cardiometabolic disorders.Besides high ...
ESSER, Nathalie +2 more
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CaMKII in Cardiometabolic Disease
Aging, 2014 The worldwide epidemic of obesity is closely linked to insulin resistance and type 2 diabetes (T2D), which have led to a critical need for new drug development. Insulin resistance and T2D contribute to the pathogenesis of many diseases including fatty liver disease, cardiovascular disease, kidney failure and retinal disease.
Lale, Ozcan, Ira, Tabas
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The incretin system and cardiometabolic disease [PDF]
Canadian Journal of Cardiology, 2010 Rates of type 2 diabetes, obesity and their associated detrimental cardiovascular effects are rapidly increasing. Despite the availability of several treatment options for type 2 diabetes and the use of intensive regimens combining several antidiabetic drugs, less than one-half of all patients reach a target glycosylated hemoglobin level of less than 7%
Paul E, Szmitko +2 more
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