Results 91 to 100 of about 103,286 (313)

Beyond the Outburst: Charting a New Frontier for Understanding and Treating Irritability in Autistic Adults

Autism Research, EarlyView.
ABSTRACT Irritability is a prevalent and impairing feature associated with autism, yet remains poorly understood, particularly in adults. Drawing heavily on insights translated from pediatric and transdiagnostic literatures, we propose that irritability in autistic individuals often reflects a psychophysiological stress or threat response, rooted in a ...
Hsiang‐Yuan Lin, Arthur N. Westover, Amy S. F. Lutz, Manish K. Jha   +3 more
wiley   +1 more source

Development, implementation and yield of a cardiometabolic health check

, 2012
Background. Cardiometabolic health checks are currently introduced in several countries in an attempt to reduce the population-wide increase of cardiometabolic disease. Objective.
Vening, Robert A., Wouda, Paul J., Spigt, Mark G., Dinant, Geert-Jan, Godefrooij, Merijn B., Knottnerus, J. Andre, van de Kerkhof, Rolf M.   +6 more
core   +1 more source

Diet Quality, Microbial Lignan Metabolites, and Cardiometabolic Health among US Adults

, 2023
The gut microbiome has been shown to play a role in the relationship between diet and cardiometabolic health. We sought to examine the degree to which key microbial lignan metabolites are involved in the relationship between diet quality and ...
Timothy P. Gill, Stephen J. Simpson, Tarik Benmarhnia, Koemel, Nicholas A., Benmarhnia, Tarik, Helen M. Parker, Michael R. Skilton, Andrew Holmes, Shah, Sanam, Nicholas A. Koemel, Nasser Laouali, Mirei Okada, Holmes, Andrew J., Oulhote, Youssef, Laouali, Nasser, Skilton, Michael R., Raubenheimer, David, Okada, Mirei, Alistair M. Senior, Parker, Helen M., Simpson, Stephen James, Youssef Oulhote, Senior, Alistair M., Gill, Timothy P., Sanam Shah, David Raubenheimer   +25 more
core   +1 more source

Myeloperoxidase as a Promising Therapeutic Target after Myocardial Infarction

Antioxidants
Coronary artery disease (CAD) and myocardial infarction (MI) remain leading causes of death and disability worldwide. CAD begins with the formation of atherosclerotic plaques within the intimal layer of the coronary arteries, a process driven by ...
Maxwell Quinn, Richard Y. K. Zhang, Idris Bello, Kerry-Anne Rye, Shane R. Thomas   +4 more
doaj   +1 more source

Dysregulation of PP2A-Akt interaction contributes to Sucrose non-fermenting related kinase (SNRK) deficiency induced insulin resistance in adipose tissue

Molecular Metabolism, 2019
Objective: We previously identified Sucrose non-fermenting related kinase (SNRK) as a regulator of adipose inflammation and energy homeostasis. In this study, we aimed to investigate the role of SNRK in insulin signaling in white (WAT) and brown adipose ...
Jie Li, Ran An, Shuiqing Lai, Linlin Li, Simin Liu, Haiyan Xu   +5 more
doaj   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Polyphenols and Cardiometabolic Health: Knowledge and Concern among Romanian People

, 2023
The cardiometabolic health of the population is a crucial indicator of public health, con-sidering the significant impact of cardiovascular disease (CVD) and diabetes on global mortality. Determining the population’s knowledge and the predictors of these
Bernadette-Emőke Teleky, Ioana Mariana Haș, Dan-Cristian Vodnar, Ioana Mariana Has,, Maria Nițescu, Delia Mirela Tit, Bianca Eugenia Ștefănescu   +6 more
core   +1 more source

Unravelling the cardio-renal-metabolic-foot connection in people with diabetes-related foot ulceration: a narrative review

Cardiovascular Diabetology
Diabetes-related foot ulceration (DFU), a serious but preventable complication of diabetes, is a leading cause of hospitalisation, lower extremity amputation and disability worldwide.
Nick S. R. Lan, Girish Dwivedi, P. Gerry Fegan, Fran Game, Emma J. Hamilton   +4 more
doaj   +1 more source

The impact of dietary interventions on cardiometabolic health

Cardiovascular Diabetology
Abstract Obesity and cardiometabolic diseases are leading causes of morbidity and mortality among adults worldwide. These conditions significantly contribute to and exacerbate other major causes of illness and death, including cancer, neurodegenerative diseases, and chronic kidney disease.
Gjermeni, E., Fiebiger, R., Bundalian, L., Garten, A., Schöneberg, T., Le Duc, D. ; https://orcid.org/0000-0001-7289-2552, Blüher, M.   +6 more
openaire   +4 more sources

Comparative efficacy of GLP‐1 RA, tirzepatide and SGLT‐2 inhibitors in metabolic liver disease: A network meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Aim Metabolic liver disease, including nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis, is a major cause of chronic liver dysfunction worldwide, creating an urgent need for effective treatments. This systematic literature review (SLR) and network meta‐analysis (NMA) systematically reviews and compares the efficacy and safety ...
Andrej Belančić, Christina Antza, Anastasios Poutachidis, Smaro Palaska, Elvira Meni Maria Gkrinia, Andrea Katrin Faour, Yusuf Ziya Sener, Seher Sener, Rehena Sultana   +8 more
wiley   +1 more source