Results 101 to 110 of about 103,286 (313)

Exposure‐adjusted safety and efficacy of GLP‐I and GLP‐1/GIP receptor agonists compared with non‐GLP‐I for weight management and type 2 diabetes: Based on FDA medical and statistical reports of 34 280 safety and 36 312 efficacy subjects

British Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to contextualize glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and glucose‐dependent insulinotropic polypeptide (GIP) receptor agonists safety and efficacy regarding weight management (WM); we analysed Food and Drug Administration (FDA) Medical Reviews to analyse 14 medications using patient‐exposure year normalization and ...
Aishwarya Prasad, Anshu Arora, Arun Arora, Jeena Vaid, Arif Khan   +4 more
wiley   +1 more source

Substituting Low-Calorie Sweetened Beverages for Sugar-Sweetened Beverages to Prevent Obesity and Cardiometabolic Diseases: Still a Good Idea? [PDF]

Low-calorie sweeteners (LCSs) and LCS-containing beverages have been proposed as appropriate substitutes for caloric sugars in recent years. In this Perspective, we highlight the recent findings from observational and interventional studies, focusing on ...
Raeisi-Dehkordi, Hamidreza, Chatelan, Angeline, Salehi-Abargouei, Amin   +2 more
core  

Overweight patterns throughout childhood and cardiometabolic markers in early adolescence [PDF]

, 2016
BACKGROUND: Risk of cardiovascular and metabolic disease is higher in adults who were relatively thin at birth and had subsequent accelerated weight gain.
dIRAS RA-2, Berentzen, N E, Wijga, A H, Berentzen, N. E., de Jongste, J. C., Wijga, AH, Gehring, U, Postma, DS, Wijga, A. H., Smit, H.A., Koppelman, G. H., Jongste, Johan, Gehring, U., Postma, D. S., Smit, H A, Berentzen, NE, Koppelman, GH, van Rossem, L., Koppelman, G. H.; id_orcid, Postma, D S, Smit, H. A., de Jongste, J C, LS IRAS EEPI ME (Milieu epidemiologie), van Rossem, L, Koppelman, G H, Smit, HA   +25 more
core   +1 more source

The Epidemiological Landscape and Burden of Chronic Disease in Australia: Contextualizing the Distinct Profile of Tasmania

Chronic Diseases and Translational Medicine, EarlyView.
ABSTRACT Chronic diseases are the leading causes of morbidity and mortality worldwide and impose a substantial and long‐lasting burden on individuals, families, communities, and healthcare systems. In Australia, more than 47% of the population had at least one chronic condition in 2018, and the prevalence rose sharply with age: approximately 80% of ...
Getahun Kebede Beyera
wiley   +1 more source

HDL-associated vitamin D binding protein levels are inversely associated with necrotic plaque burden in psoriasis

Atherosclerosis Plus
Background and aims: Vitamin D binding protein (DBP) serves a dual function as a vitamin D carrier and actin scavenger. Free DBP is present in high concentrations in serum, while a smaller pool is bound to lipoproteins like HDL and VLDL.
M.P. Playford, H. Li, A.K. Dey, E.M. Florida, H.L. Teague, S.M. Gordon, N.N. Mehta   +6 more
doaj   +1 more source

Plasma Exosome Metabolomics Reveal Stage‐Specific Alterations in Elderly Women With Premetabolic and Metabolic Syndrome

Chronic Diseases and Translational Medicine, EarlyView.
Shared differential metabolites identified across the three sample groups. (A) Venn diagram of differential metabolites between the two comparison groups; Based on the detected levels of these overlapping differential metabolites, (B) d‐Arabitol, (C) Triclosan, (D) Iloprost, (E) Tetracosanoic acid, and (F) Omeprazole sulfone. Box plots were constructed
Mengtao Qian, Dan Nie, Qianyi Gao, Xingbo Mo, Huan Zhang   +4 more
wiley   +1 more source

Global positioning system-based food environment exposures, diet-related, and cardiometabolic health outcomes: a systematic review and research agenda [PDF]

Background: Geographic access to food may affect dietary choices and health outcomes, but the strength and direction of associations may depend on the operationalization of exposure measures. We aimed to systematically review the literature on up-to-date
Wei, Lai, Helbich, Marco, Mackenbach, Joreintje D., Siddiqui, Noreen Z., Beulens, Joline W.J., Schoonmade, Linda J., Pinho, Maria G.M.   +6 more
core  

Resveratrol attenuates high glucose-induced inflammation and improves glucose metabolism in HepG2 cells

Scientific Reports
Diabetes mellitus (DM) is characterized by impaired glucose and insulin metabolism, resulting in chronic hyperglycemia. Hyperglycemia-induced inflammation is linked to the onset and progression of diabetes. Resveratrol (RES), a polyphenol phytoalexin, is
Abegail Mukhethwa Tshivhase, Tandi Matsha, Shanel Raghubeer   +2 more
doaj   +1 more source

Comprehensive exploration of unexplained dyspnoea in subjects with normal ejection fraction and low natriuretic peptides

ESC Heart Failure, Volume 12, Issue 2, Page 879-887, April 2025.
Abstract Background Unexplained exertional dyspnoea without significant elevation of natriuretic peptides is common. One of the causes might be early heart failure with preserved ejection fraction (HFpEF). Aims This study aimed to characterize patients with exertional dyspnoea and normal/near‐to‐normal N‐terminal pro‐brain natriuretic peptide (NT ...
Emmanuelle Berthelot, Tarek Laouar, Antoine Beurnier, Nataliya Hrynchynshyn, Jean Christophe Eicher, Jean‐Michel Tartière, Patrick Jourdain, Olivier Lairez, Barnabas Gellen   +8 more
wiley   +1 more source

Long-term effects of a preconception lifestyle intervention on cardiometabolic health of overweight and obese women [PDF]

, 2018
Background: The global prevalence of obesity in women keeps increasing. The preconception period may be a window of opportunity to improve lifestyle, reduce obesity and improve cardiometabolic health.
Eriksson, Johan G, Wekker, V., Zwinderman, Aeilko H, Groen, Henk; id_orcid, Eriksson, J.G., Hoek, Annemieke, Cornelieke van de Beek, Roseboom, T.J., van de Beek, Cornelieke, Painter, Rebecca C., Aeilko H Zwinderman, Saila B Koivusalo, van Dammen, Lotte, Emilia Huvinen, Rono, Kristiina, Koivusalo, Saila B., Rebecca C Painter, Kristiina Rono, Painter, Rebecca C, Groen, Henk, Wekker, Vincent, Henk Groen, Annemieke Hoek, Zwinderman, Aeilko H., Roseboom, Tessa J, Koivusalo, S.B., van Dammen, L., Huvinen, E., Tessa J Roseboom, Mol, Ben Willem J., Huvinen, Emilia, Koivusalo, Saila B, Rono, K., Johan G Eriksson, Groen, H., Mol, Ben Willem J, Eriksson, Johan G., Ben Willem J Mol, Lotte van Dammen, Zwinderman, A.H., Mol, B.W.J., Taisto Sarkola, Sarkola, Taisto, Sarkola, T., Hoek, A., Vincent Wekker, van de Beek, C., Roseboom, Tessa J., Painter, R.C.   +48 more
core   +1 more source