Results 221 to 230 of about 180,189 (308)

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Lamin B1 loss in human cardiomyocytes is associated with nuclear shape deformation in dilated cardiomyopathy. [PDF]

J Mol Cell Cardiol Plus
Ventimiglia LN, Zelezniak A, Dos Remedios CG, Lal S, Ehler E, De Nicola GF.   +5 more
europepmc   +1 more source

Cardiac remodelling in the era of the recommended four pillars heart failure medical therapy

ESC Heart Failure, Volume 12, Issue 2, Page 1029-1044, April 2025.
Abstract Cardiac remodelling is a key determinant of worse cardiovascular outcome in patients with heart failure (HF) and reduced ejection fraction (HFrEF). It affects both the left ventricle (LV) structure and function as well as the left atrium (LA) and the right ventricle (RV).
Giada Colombo, Tor Biering‐Sorensen, Joao P. Ferreira, Carlo Mario Lombardi, Andrea Bonelli, Andrea Garascia, Marco Metra, Riccardo M. Inciardi   +7 more
wiley   +1 more source

Frataxin deficiency drives cardiac dysfunction and transcriptional dysregulation in Friedreich ataxia iPSC model. [PDF]

Cell Death Dis
Lees JG, Zhang H, Jiao L, Kong AM, Phang RJ, Li L, Su N, Bass-Stringer S, Woo HH, Mukhtar AS, Pébay A, Dottori M, Corben L, Delatycki M, Peverill R, Wilcox S, Choi J, Pullin JM, McCarthy D, Napierala JS, Napierala M, Lim SY.   +21 more
europepmc   +1 more source

Dynamic cardiac hyperplasia and hypertrophy in Burmese pythons. [PDF]

Am J Physiol Cell Physiol
Tan Y, Martin TG, Peter AK, Ozeroff CD, Ebmeier CC, Doptis R, Harrison B, Leinwand LA.   +7 more
europepmc   +1 more source

The effects of sodium–glucose cotransporter 2 inhibitors on the ‘forgotten’ right ventricle

ESC Heart Failure, Volume 12, Issue 2, Page 1045-1058, April 2025.
Abstract With the progress in diagnosis, treatment and imaging techniques, there is a growing recognition that impaired right ventricular (RV) function profoundly affects the prognosis of patients with heart failure (HF), irrespective of their left ventricular ejection fraction (LVEF).
Liangzhen Qu, Xueting Duan, Han Chen
wiley   +1 more source

MicroRNAs and SGLT2 inhibitors in cardiovascular disease: Shared pathways and emerging roles. [PDF]

J Mol Cell Cardiol Plus
Bhaskaran AB, Sakr A, Doycheva D.
europepmc   +1 more source

Lean ZSF1 rats in basic research on heart failure with preserved ejection fraction

ESC Heart Failure, Volume 12, Issue 2, Page 1474-1478, April 2025.
Abstract Aims ZSF1 obese rats harbouring two mutant leptin receptor alleles (Leprcp and Leprfa) develop metabolic syndrome and heart failure with preserved ejection fraction (HFpEF), making them a widely used animal model in cardiometabolic research.
Petra Büttner, Antje Augstein, Mahmoud Abdellatif, André Lourenço, Adelino Leite‐Moreira, Inês Falcão‐Pires, Sarah Werner, Holger Thiele, Simon Sedej, Antje Schauer, Volker Adams   +10 more
wiley   +1 more source

PRDM16 modulates aspects of cell cycle dynamics and maturation in human iPSC-derived cardiomyocytes. [PDF]

Stem Cell Reports
Tani K, Matsumura Y, Nishikawa M, Narita M, Putri Elvandari A, Lucena-Cacace A, Yoshida Y.   +6 more
europepmc   +1 more source

Interventional therapies for chronic heart failure: An overview of recent developments

ESC Heart Failure, Volume 12, Issue 2, Page 1081-1094, April 2025.
Abstract Heart failure (HF), the final manifestation of most cardiovascular diseases, has become a major global health concern, affecting millions of individuals. Despite basic drug treatments, patients present with high morbidity and mortality rates. However, recent advancements in interventional therapy have shown promising results in improving the ...
Bingchen Guo, Si Shi, Yutong Guo, Jie Xiong, Bo Wang, Zengxiang Dong, Dianyu Gao, Yingfeng Tu   +7 more
wiley   +1 more source