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Heart Failure Clinics, 2005
Heart failure is a syndrome that arises primarily from a loss of power of the contracting muscle of the heart. Genetic studies have shown that some ‘‘idiopathic’’ dilated cardiomyopathies are caused by a defect in the individual muscle units of the heart (cardiomyocytes), such as a mutation in the proteins of the sarcomere, which leads directly to poor
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Heart failure is a syndrome that arises primarily from a loss of power of the contracting muscle of the heart. Genetic studies have shown that some ‘‘idiopathic’’ dilated cardiomyopathies are caused by a defect in the individual muscle units of the heart (cardiomyocytes), such as a mutation in the proteins of the sarcomere, which leads directly to poor
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Microtopographical assembly of cardiomyocytes
Integrative Biology, 2011One of the central challenges in cardiac tissue engineering is the control of the assembly and organization of functional cardiac tissue. Maintenance of a three-dimensional tissue architecture is key to myocardial function in vivo, and a variety of studies hint that provision of topological cues within scaffolds can facilitate the engineering of ...
Anuj A, Patel +2 more
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Glycation in the cardiomyocyte
Glycation is a protein post-translational modification that can occur on lysine and arginine residues as a result of a non-enzymatic process known as the Maillard reaction. This modification is irreversible, so the only way it can be removed is by protein degradation and replacement.Christine E, Delligatti +1 more
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Isolation and Differentiation of Human Cardiomyocyte Progenitor Cells into Cardiomyocytes
2012To date, there is no suitable in vitro model to study human adult cardiac cell biology. Here, we describe a method for efficient isolation and expansion of human cardiomyocyte progenitor cells (CMPCs) from cardiac surgical waste or, alternatively, from fetal heart tissue.
Anke M, Smits +2 more
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Cryopreservation of Neonatal Cardiomyocytes
2015Cardiomyocytes are frequently used for in vitro models for cardiac research. The isolation of cells is time-consuming and, due to the cells limited proliferative abilities, must be performed frequently. To reduce the time requirements and the impact on research animals, we describe a method for cryopreserving neonatal rat cardiomyocytes (NRCMs), and ...
Adam C, Vandergriff +2 more
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Pathophysiology of Cardiomyocytesa
Annals of the New York Academy of Sciences, 1988Isolated cardiomyocytes lend themselves very well to the quantification of pathological damage and to the determination of reversible versus irreversible changes. These single cells were used to study the cellular response to a variety of pathologic stimuli that impair structure and function.
M, Borgers +2 more
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The electrophysiological development of cardiomyocytes
Advanced Drug Delivery Reviews, 2016The generation of human cardiomyocytes (CMs) from human pluripotent stem cells (hPSCs) has become an important resource for modeling human cardiac disease and for drug screening, and also holds significant potential for cardiac regeneration. Many challenges remain to be overcome however, before innovation in this field can translate into a change in ...
Jie, Liu +2 more
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Doxorubicin Degradation in Cardiomyocytes
The Journal of Pharmacology and Experimental Therapeutics, 2007Antitumor therapy with the anthracycline doxorubicin is limited by a severe cardiotoxicity, which seems to correlate with the cardiac levels of doxorubicin and its metabolization to reactive oxygen species. Previous biochemical studies showed that hydrogen peroxide-activated myoglobin caused an oxidative degradation of doxorubicin; however, a ...
Pierantonio, Menna +2 more
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Resuscitation of a dead cardiomyocyte
Heart Failure Reviews, 2015Although cardiac resuscitation can revive the whole body, the mechanisms are unclear. To this end, we propose that reviving a dead/dysfunctional cardiomyocyte will shed light on resuscitation mechanisms and pave the way to treat cardiac myopathies. The degradation of the myocyte cytoskeleton by the proteasome system which involves calpains, ubiquitin ...
George H, Kunkel +2 more
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Tissue factor and cardiomyocytes
Thrombosis Research, 2012Tissue factor, the initiator of blood coagulation, plays a major role in the protection of several organs against bleeding. Cardiomyocytes and fibroblasts constitutively express tissue factor. Besides its role for maintain cardiac hemostasis TF has been suggested to have several other important functions in the cardiac muscle.
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