Results 91 to 100 of about 296,757 (381)
Patient and Disease-Specific Induced Pluripotent Stem Cells for Discovery of Personalized Cardiovascular Drugs and Therapeutics. [PDF]
, 2020 Human induced pluripotent stem cells (iPSCs) have emerged as an effective platform for regenerative therapy, disease modeling, and drug discovery.
Chandy, Mark +2 more
core
Classification, Epidemiology, and Global Burden of Cardiomyopathies.
Circulation Research, 2017 In the past 25 years, major advances were achieved in the nosography of cardiomyopathies, influencing the definition and taxonomy of this important chapter of cardiovascular disease.
W. McKenna, B. Maron, G. Thiene
semanticscholar +1 more source
Advanced Science, EarlyView.Overview of the Genetic Deafness Commons (GDC), integrating data from the Chinese Deafness Genetics Consortium (CDGC) and 51 public databases. The GDC provides tools for variant search, functional predictions, and gene‐disease visualization, offering insights into 201 hearing loss genes and facilitating novel gene discovery and clinical applications ...
Hui Cheng +11 more
wiley +1 more source
Non-familial cardiomyopathies in Lebanon: exome sequencing results for five idiopathic cases
BMC Medical Genomics, 2019 Background Cardiomyopathies affect more than 0.5% of the general population. They are associated with high risk of sudden cardiac death, which can result from either heart failure or electrical abnormalities.
Marwan M. Refaat +14 more
doaj +1 more source
Clinical Genetics, 2019 Pathogenic variants in FLNC encoding filamin C have been firstly reported to cause myopathies, and were recently linked to isolated cardiac phenotypes. Our aim was to estimate the prevalence of FLNC pathogenic variants in subtypes of cardiomyopathies and
F. Ader +18 more
semanticscholar +1 more source
Molecular Basis of Inflammation in the Pathogenesis of Cardiomyopathies
International Journal of Molecular Sciences, 2020 Cardiomyopathies (CMPs) represent a diverse group of heart muscle diseases, grouped into specific morphological and functional phenotypes. CMPs are associated with mutations in sarcomeric and non-sarcomeric genes, with several suspected epigenetic and ...
E. Monda +18 more
semanticscholar +1 more source
An arcane cardiomyopathy [PDF]
Netherlands Heart Journal, 2014 Last February, the Lancet and the New England Journal of Medicine almost simultaneously published two interesting case reports on an arcane cardiomyopathy [1, 2]. The New York Times drew attention to these papers in their Health Section as ‘A Medical Mystery Solved’. A 55-year-old man is described.
openaire +3 more sources
Advanced Science, EarlyView.In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang +10 more
wiley +1 more source
Cell Death and DiseaseArrhythmogenic cardiomyopathy (ACM) is an inherited cardiac disorder that causes sudden cardiac death and progressive heart failure. Besides fibro-fatty replacement and myocyte degenerative changes, inflammatory patchy infiltrates are found in myocardial
Salwa Soussi +14 more
doaj +1 more source
Frontiers in Cardiovascular MedicineIntroductionHypertrophic cardiomyopathy (HCM) is a common genetic cardiac disease marked by abnormal ventricular hypertrophy. Recent studies have highlighted that left atrial (LA) remodelling—including dilation, fibrosis, and functional impairment—plays ...
Chiara Piazzai +6 more
doaj +1 more source