Results 131 to 140 of about 305,984 (384)

Genome-wide transcriptomics analysis identifies sox7 and sox18 as specifically regulated by gata4 in cardiomyogenesis [PDF]

, 2017
This work was supported by British Heart Foundation (BHF Project Grant no PG/13/23/30080 to B.A.A and S.H.), Biotechnology and Biological Sciences Research Council (BB/M001695/1 to S.H.) and the University of Aberdeen (for A.T.L).
Afouda, Boni A, De Paiva Alves, Eduardo, Hoppler, Stefan, Lynch, Adam T   +3 more
core   +1 more source

Mitochondrial Adaptation to Mechanical Stress in Cardiac Ageing and Disease

Advanced Science, EarlyView.
Mechanical forces shape the heart's energy factories. This review explores how mitochondria in cardiac cells sense and respond to biomechanical stress, altering their structure, positioning, and metabolism. By linking mechanical cues to mitochondrial adaptation, the article highlights pathways driving heart disease and points to new strategies for ...
Aishwarya Prakash, Thomas Iskratsch
wiley   +1 more source

Genetic Basis and Molecular Biology of Cardiac Arrhythmias in Cardiomyopathies.

Cardiovascular Research, 2020
Cardiac arrhythmias are common, often the first, and sometimes the life-threatening manifestations of hereditary cardiomyopathies. Pathogenic variants in several genes known to cause hereditary cardiac arrhythmias have also been identified in the ...
A. Marian, B. Asatryan, X. Wehrens
semanticscholar   +1 more source

Feline Hypertrophic Cardiomyopathy: A Spontaneous Large Animal Model of Human HCM. [PDF]

, 2017
Hypertrophic cardiomyopathy (HCM) is a common disease in pet cats, affecting 10-15% of the pet cat population. The similarity to human HCM, the rapid progression of disease, and the defined and readily determined endpoints of feline HCM make it an ...
Freeman, Lisa M, Huggins, Gordon S, Maron, Martin S, Rush, John E, Stern, Joshua A   +4 more
core   +2 more sources

Leucine‐Dependent SLC7A5–PGAM5 Interaction Promotes Advanced Atherosclerosis Through Hindering Mitochondrial Function of Macrophages

Advanced Science, EarlyView.
Higher plasma leucine is associated with increased risk of new‐onset myocardial infarction. Leucine deprivation alleviates advanced atherosclerosis in mice. Tumor‐induced leucine deprivation reprograms macrophage metabolism and increases CD5Lhi macrophages in mouse plaques. Mechanistically, leucine deficiency reduced SLC7A5‐PGAM5 binding in macrophages,
Shan Zhong, Xueyu Wang, Qingsong Li, Siqi Wang, Bin Sun, Wenjun Ni, Gengyu Zhou, Fan Wang, Xianwei Xie, Cheng Jin, Gang Xu, Peng Zhao, Xiang Peng, Feiyuan Han, Xiangwen Xi, Yidan Wang, Juan Xu, Yue Wang, Xia Gu, Shuo Li, Jian Zhang, Shuijie Li, Jinwei Tian   +22 more
wiley   +1 more source

Unraveling the genetic tapestry of pediatric sarcomeric cardiomyopathies and masquerading phenocopies in Jordan

Scientific Reports
Pediatric cardiomyopathies are mostly attributed to variants in sarcomere-related genes. Unfortunately, the genetic architecture of pediatric cardiomyopathies has never been previously studied in Jordan.
Bilal Azab, Dunia Aburizeg, Sherin T. Shaaban, Weizhen Ji, Lina Mustafa, Nooredeen Jamal Isbeih, Amal Saleh Al-Akily, Hashim Mohammad, Lauren Jeffries, Mustafa Khokha, Saquib A. Lakhani, Iyad Al-Ammouri   +11 more
doaj   +1 more source

The Immune Microenvironment in Liver Cancer: From Analysis to Targeting

Advanced Science, EarlyView.
This review explores how smart nanomedicines overcome the immunosuppressive tumor microenvironment in liver cancer. It details targeted delivery strategies and immune reprogramming mechanisms, including remodeling abnormal physiology, modulating metabolism, and inducing immunogenic cell death. The article highlights the paradigm shift toward multimodal
Jiaming Lan, Hao Li, Jian Xue, Yourong Duan, Jin Sun, Meng Niu   +5 more
wiley   +1 more source

Personalized care in dilated cardiomyopathy: Rationale and study design of the activeDCM trial

ESC Heart Failure
Background Dilated cardiomyopathy (DCM) is a leading cause of heart failure, particularly in younger individuals. Low physical strength is a global risk factor for cardiovascular mortality, and physical activity and a healthy lifestyle have been shown to
Farbod Sedaghat‐Hamedani, Ali Amr, Theresa Betz, Elham Kayvanpour, Christoph Reich, Reto Wettstein, Oliver Heinze, Isabell Mohr, Regina Krisam, Anja Sander, Christina Klose, Birgit Friedmann‐Bette, Norbert Frey, Benjamin Meder   +13 more
doaj   +1 more source

Allergy and the Heart

JACC: Case Reports, 2020
A 40-year-old woman with history of atopy and peripheral eosinophilia presented with clinical signs of heart failure. Echocardiography revealed a restrictive cardiomyopathy with biventricular thrombi.
Cullen E. Buchanan, MD, Ekta Kakkar, MD, Stephen C. Dreskin, MD, PhD, Larry A. Allen, MD, MHS, Daniel W. Groves, MD, Natasha L. Altman, MD   +5 more
doaj   +1 more source

Longitudinal quantile regression in presence of informative drop-out through longitudinal-survival joint modeling

, 2014
We propose a joint model for a time-to-event outcome and a quantile of a continuous response repeatedly measured over time. The quantile and survival processes are associated via shared latent and manifest variables.
Aalen, Andersen, Andrews, Buchinsky, Clements, Cowie, Cox, Daniel-Spiegel, Diggle, Doucet, Eickoff, Farcomeni, Farcomeni, Follmann, Geraci, Geraci, Geraci, Gilks, Gill, Henderson, Heritier, Hsieh, Kahaner, Keren, Koenker, Koenker, Kurland, Levine, Lipsitz, Little, Little, Liu, Liu, Merlo, Molenberghs, Ndrepepa, Nelder, Nelson, Nielsen, Rizopoulos, Rizopoulos, Rizopoulos, Rizopoulos, Sandri, Tsiatis, Verbeke, Verbeke, Viviani, Vonesh, Wei, Wu, Wu, Wu, Wulfsohn, Yi, Yu, Yuan   +56 more
core   +1 more source