Results 151 to 160 of about 296,757 (381)
Advanced Science, EarlyView.Schematic overview showing that forkhead box O6, opposite strand (Foxo6os) acts as a “scaffold”, directly binding myosin‐binding protein‐C (MYBPC3) and recruiting protein kinase C (PKC‐α) to mediate site‐specific phosphorylation of MYBPC3. This post‐translational modification supports cardiac contraction by regulating L‐type Ca2+ channels, especially ...
Jie Sheng +9 more
wiley +1 more source
Targeting the sarcomere in inherited cardiomyopathies
Nature Reviews Cardiology, 2022 Sarah J. Lehman, C. Crocini, L. Leinwand
semanticscholar +1 more source
Human Induced Pluripotent Stem-Cell-Derived Cardiomyocytes as Models for Genetic Cardiomyopathies
International Journal of Molecular Sciences, 2019 In the last few decades, many pathogenic or likely pathogenic genetic mutations in over hundred different genes have been described for non-ischemic, genetic cardiomyopathies.
A. Brodehl +6 more
semanticscholar +1 more source
Atrial Fibroblasts‐Derived Extracellular Vesicles Exacerbate Atrial Arrhythmogenesis
Advanced Science, EarlyView.Exosome miR‐224‐5p derived from angiotensin II‐treated atrial fibroblasts creates a substrate for AF by promoting atrial electrical remodeling. Increased exosome miR‐224‐5p enhances AF susceptibility by inhibiting CACNA1c expression and decreasing ICa current of atrial cardiomyocytes.
Yue Yuan +13 more
wiley +1 more source
Pathobiology of cardiomyopathies: Experience at a Tertiary Care Center
Journal of the Practice of Cardiovascular Sciences, 2015 Background: Cardiomyopathies are a heterogeneous group of diseases of the myocardium associated with varied pathology. Pathology data from India are scarce.
Uma Nahar Saikia +5 more
doaj +1 more source
Nonischemic left ventricular scar and cardiac sudden death in the young [PDF]
, 2016 Nonischemic Left Ventricular Scar (NLVS) is a pattern of myocardial injury characterized by midventricular and/or subepicardial gadolinium hyper enhancement at cardiac magnetic resonance, in absence of significant coronary artery disease.
CERBELLI, BRUNA +10 more
core +1 more source
Advanced Science, EarlyView.FOXM1 maintains mitochondrial bioenergetic function by inhibiting MKRN1‐mediated ubiquitination of LKB1 in cardiomyocytes. Loss of FOXM1 in cardiomyocytes results in upregulation of MKRN1, which enhances LKB1 ubiquitination and disrupts AMPK signaling and energy metabolism pathways. Conversely, FOXM1 overexpression preserves mitochondrial bioenergetics
Shuai Song +17 more
wiley +1 more source
Comprehensive genetic analysis of poorly differentiated gastric cancer in young females
Annals of Gastroenterological Surgery, EarlyView.Although the involvement of female sex hormones in the development of poorly differentiated gastric cancer in young females is controversial, our detailed analysis using RNA‐seq suggested that the female sex hormone, β‐estradiol plays a role in the development of poorly differentiated gastric cancer in young females. Abstract Aim The reasons behind the
Nobuhiro Nakazawa +9 more
wiley +1 more source
HAeMODYNAMIC EFFECTS OF CHANGES IN BLOOD VOLUME IN HYPERTROPHIC OBSTRUCTIVE CARDIOMYOPATHY [PDF]
, 1965 Pravin M. Shah +2 more
openalex +1 more source
Journal of Cardiovascular Development and Disease, 2016 Cardiovascular diseases and, among them, channelopathies and cardiomyopathies are a major cause of death worldwide. The molecular and genetic defects underlying these cardiac disorders are complex, leading to a large range of structural and functional ...
Ouarda Taghli-Lamallem +2 more
doaj +1 more source