Results 31 to 40 of about 44,322 (189)

The Role of Quality Control in Targeted Next-generation Sequencing Library Preparation

Genomics, Proteomics & Bioinformatics, 2016
Next-generation sequencing (NGS) is getting routinely used in the diagnosis of hereditary diseases, such as human cardiomyopathies. Hence, it is of utter importance to secure high quality sequencing data, enabling the identification of disease-relevant ...
Rouven Nietsch, Jan Haas, Alan Lai, Daniel Oehler, Stefan Mester, Karen S. Frese, Farbod Sedaghat-Hamedani, Elham Kayvanpour, Andreas Keller, Benjamin Meder   +9 more
doaj   +1 more source

Cardiomyopathies.

Acta bio-medica : Atenei Parmensis, 2019
The most common cardiomyopathies often present to primary care physicians with similar symptoms, despite the fact that they involve a variety of phenotypes and etiologies (1). Many have signs and symptoms common in heart failure, such as reduced ejection fraction, peripheral edema, fatigue, orthopnea, exertion dyspnea, paroxysmal nocturnal dyspnea ...
Precone, Vincenza, Krasi, Geraldo, Guerri, Giulia, Madureri, Alberto, Piazzani, Mariangela, Michelini, Sandro, Barati, Shila, Maniscalchi, Tiziana, Bressan, Simone, Bertelli, Matteo   +9 more
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Cardiomyopathies in China: A 2018–2019 state-of-the-art review

Chronic Diseases and Translational Medicine, 2020
Cardiomyopathies are diseases of the cardiac muscle and are often characterized by ventricular dilation, hypertrophy, and cardiac arrhythmia. Patients with cardiomyopathies often experience sudden death and cardiac failure and require cardiac ...
Tian-Rui Hua, Shu-Yang Zhang
doaj   +1 more source

Arrhythmogenic Cardiomyopathy [PDF]

Circulation Research, 2017
Arrhythmogenic cardiomyopathy is an inherited heart muscle disorder, predisposing to sudden cardiac death, particularly in young patients and athletes. Pathological features include loss of myocytes and fibrofatty replacement of right ventricular myocardium; biventricular involvement is often observed.
Corrado, Domenico, Basso, Cristina, Judge, Daniel P.   +2 more
openaire   +3 more sources

Transcriptome data analysis of primary cardiomyopathies reveals perturbations in arachidonic acid metabolism

Frontiers in Cardiovascular Medicine, 2023
IntroductionCardiomyopathies are complex heart diseases with significant prevalence around the world. Among these, primary forms are the major contributors to heart failure and sudden cardiac death.
Pankaj Kumar Chauhan, Ramanathan Sowdhamini, Ramanathan Sowdhamini, Ramanathan Sowdhamini   +3 more
doaj   +1 more source

Targeting lipid metabolism as a new therapeutic strategy for inherited cardiomyopathies

Frontiers in Cardiovascular Medicine, 2023
Inherited cardiomyopathies caused by pathological genetic variants include multiple subtypes of heart disease. Advances in next-generation sequencing (NGS) techniques have allowed for the identification of numerous genetic variants as pathological ...
Karen R. Gaar-Humphreys, Karen R. Gaar-Humphreys, Alyssa van den Brink, Alyssa van den Brink, Mark Wekking, Mark Wekking, Folkert W. Asselbergs, Folkert W. Asselbergs, Frank G. van Steenbeek, Frank G. van Steenbeek, Frank G. van Steenbeek, Magdalena Harakalova, Magdalena Harakalova, Magdalena Harakalova, Jiayi Pei, Jiayi Pei, Jiayi Pei   +16 more
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Dilated cardiomyopathies and non-compaction cardiomyopathy [PDF]

Herz, 2020
AbstractDilated cardiomyopathy (DCM) is the most common form of cardiomyopathy and one of the most common causes of heart failure. It is characterized by left or biventricular dilation and a reduced systolic function. The causes are manifold and range from myocarditis to alcohol and other toxins, to rheumatological, endocrinological, and metabolic ...
Hänselmann, A., Veltmann, C., Bauersachs, J., Berliner, D.   +3 more
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Translating emerging molecular genetic insights into clinical practice in inherited cardiomyopathies. [PDF]

, 2018
Cardiomyopathies are primarily genetic disorders of the myocardium associated with higher risk of life-threatening cardiac arrhythmias, heart failure, and sudden cardiac death.
Medeiros-Domingo, Argelia, Asatryan, Babken   +1 more
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The Feline Cardiomyopathies: 2. Hypertrophic cardiomyopathy

Journal of Feline Medicine and Surgery, 2021
Practical relevance: Hypertrophic cardiomyopathy (HCM) is the most common form of feline cardiomyopathy observed clinically and may affect up to approximately 15% of the domestic cat population, primarily as a subclinical disease. Fortunately, severe HCM, leading to heart failure or arterial thromboembolism (ATE)
Kittleson, Mark D, Côté, Etienne
openaire   +3 more sources

Prelamin A mediates myocardial inflammation in dilated and HIV-associated cardiomyopathies [PDF]

, 2019
Cardiomyopathies are complex heart muscle diseases that can be inherited or acquired. Dilated cardiomyopathy can result from mutations in LMNA, encoding the nuclear intermediate filament proteins lamin A/C. Some LMNA mutations lead to accumulation of the
Vizcay-Barrena, G., Russo, M.A., Hayward, R., dos Remedios, C.G., Protti, A., Zammit, P.S., Ehler, E., Ahmad, S.M., Shah, A.M., Frustaci, A., Brayson, D., Shanahan, C.M., Chimenti, C., Verardo, R.   +13 more
core   +1 more source