Results 1 to 10 of about 445,411 (164)

Dilated cardiomyopathy [PDF]

Nature Reviews Disease Primers, 2019
Dilated cardiomyopathy (DCM) is a clinical diagnosis characterized by left ventricular or biventricular dilation and impaired contraction that is not explained by abnormal loading conditions (for example, hypertension and valvular heart disease) or coronary artery disease.
Schultheiss H. -P., Fairweather D. L., Caforio A. L. P., Escher F., Hershberger R. E., Lipshultz S. E., Liu P. P., Matsumori A., MAZZANTI, ANDREA, McMurray J., Priori S. G.   +10 more
semanticscholar   +9 more sources

Immune-inflammatory concept of the pathogenesis of chronic heart failure in dogs with dilated cardiomyopathy [PDF]

Veterinary World, 2019
Background: Dilated cardiomyopathy is common in dogs. This form of cardiomyopathy is the main cause of death due to heart disease in dogs. Death can occur suddenly in clinically normal animals as a result of the progression of congestive heart failure ...
Yu Vatnikov, A. Rudenko, P. Rudenko, Ev Kulikov, A. Karamyan, V. Lutsay, I. Medvedev, V. Byakhova, E. Krotova, M. Molvhanova   +9 more
doaj   +2 more sources

Natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy

Genome Biology, 2017
Background Genetic variation is an important determinant of RNA transcription and splicing, which in turn contributes to variation in human traits, including cardiovascular diseases. Results Here we report the first in-depth survey of heart transcriptome
Matthias Heinig, Michiel E. Adriaens, Sebastian Schafer, Hanneke W. M. van Deutekom, Elisabeth M. Lodder, James S. Ware, Valentin Schneider, Leanne E. Felkin, Esther E. Creemers, Benjamin Meder, Hugo A. Katus, Frank Rühle, Monika Stoll, François Cambien, Eric Villard, Philippe Charron, Andras Varro, Nanette H. Bishopric, Alfred L. George, Cristobal dos Remedios, Aida Moreno-Moral, Francesco Pesce, Anja Bauerfeind, Franz Rüschendorf, Carola Rintisch, Enrico Petretto, Paul J. Barton, Stuart A. Cook, Yigal M. Pinto, Connie R. Bezzina, Norbert Hubner   +30 more
doaj   +2 more sources

Neonatal dilated cardiomyopathy

Revista Portuguesa de Cardiologia, 2017
Cardiomyopathies are rare diseases of the heart muscle, of multiple causes, that manifest with various structural and functional phenotypes but are invariably associated with cardiac dysfunction.
Paulo Soares, Gustavo Rocha, Susana Pissarra, Henrique Soares, Filipa Flôr-de-Lima, Sandra Costa, Cláudia Moura, Sofia Dória, Hercília Guimarães   +8 more
doaj   +4 more sources

Dilated cardiomyopathy [PDF]

Circulation: Arrhythmia and Electrophysiology, 2013
Epidemiology, aetiology, pathophysiology, diagnosis, and therapy of patients with dilated cardiomyopathy are discussed. Recommendations on the use of CRT and ICD therapy by the ACC/AHA and ESC are presented.
Demosthenes G. Katritsis, Bernard J. Gersh, A. John Camm   +2 more
openaire   +3 more sources

Precise genomic editing of pathogenic mutations in RBM20 rescues dilated cardiomyopathy

Science Translational Medicine, 2022
Mutations in RNA binding motif protein 20 (RBM20) are a common cause of familial dilated cardiomyopathy (DCM). Many RBM20 mutations cluster within an arginine/serine-rich (RS-rich) domain, which mediates nuclear localization. These mutations induce RBM20
Takahiko Nishiyama, Yu Zhang, Miao Cui, Hui Li, E. Sánchez-Ortiz, John R. McAnally, Wei Tan, Jiwoong Kim, Kenian Chen, Lin Xu, R. Bassel-Duby, E. Olson   +11 more
semanticscholar   +1 more source

Evidence-Based Assessment of Genes in Dilated Cardiomyopathy

Circulation, 2021
Supplemental Digital Content is available in the text. Background: Each of the cardiomyopathies, classically categorized as hypertrophic cardiomyopathy, dilated cardiomyopathy (DCM), and arrhythmogenic right ventricular cardiomyopathy, has a signature ...
Elizabeth Jordan, Laiken Peterson, Tomohiko Ai, B. Asatryan, L. Bronicki, Emily E. Brown, R. Celeghin, Matthew Edwards, Judy Fan, J. Ingles, C. James, O. Jarinova, Renee Johnson, Daniel P. Judge, N. Lahrouchi, R. L. Lekanne Deprez, R. Lumbers, F. Mazzarotto, A. Medeiros Domingo, Rebecca L. Miller, A. Morales, B. Murray, Stacey Peters, K. Pilichou, Alexandros Protonotarios, C. Semsarian, Palak Shah, P. Syrris, C. Thaxton, J. V. van Tintelen, R. Walsh, Jessica Wang, James S. Ware, R. E. Hershberger   +33 more
semanticscholar   +1 more source

Truncated titin proteins in dilated cardiomyopathy

Science Translational Medicine, 2021
Description Truncating mutations in TTN result in both truncated titin proteins and reduced full-length titin in patient hearts. Tracking titin in dilated cardiomyopathy Truncating variants in TTN, the gene encoding the titin protein, underlie 15 to 25 ...
Q. McAfee, C. Y. Chen, Yifan Yang, M. Caporizzo, M. Morley, A. Babu, Sunhye Jeong, Jeffrey Brandimarto, K. Bedi, Emily Flam, Joseph Cesare, T. Cappola, K. Margulies, B. Prosser, Z. Arany   +14 more
semanticscholar   +1 more source

A predictive model for canine dilated cardiomyopathy—a meta-analysis of Doberman Pinscher data [PDF]

PeerJ, 2015
Dilated cardiomyopathy is a prevalent and often fatal disease in humans and dogs. Indeed dilated cardiomyopathy is the third most common form of cardiac disease in humans, reported to affect approximately 36 individuals per 100,000 individuals.
Siobhan Simpson, Jennifer Edwards, Richard D. Emes, Malcolm A. Cobb, Nigel P. Mongan, Catrin S. Rutland   +5 more
doaj   +2 more sources

The combination of carboxy‐terminal propeptide of procollagen type I blood levels and late gadolinium enhancement at cardiac magnetic resonance provides additional prognostic information in idiopathic dilated cardiomyopathy – A multilevel assessment of myocardial fibrosis in dilated cardiomyopathy

European Journal of Heart Failure, 2021
To determine the prognostic value of multilevel assessment of fibrosis in dilated cardiomyopathy (DCM) patients.
A. Raafs, J. Verdonschot, M. Henkens, B. Adriaans, Ping Wang, K. Derks, M. A. Abdul Hamid, C. Knackstedt, V. V. van Empel, J. Díez, H. Brunner-la Rocca, H. Brunner, Arantxa González, S. Bekkers, S. Heymans, M. Hazebroek   +15 more
semanticscholar   +1 more source