Results 11 to 20 of about 120,376 (304)

Natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy [PDF]

Genome Biology, 2017
Background Genetic variation is an important determinant of RNA transcription and splicing, which in turn contributes to variation in human traits, including cardiovascular diseases. Results Here we report the first in-depth survey of heart transcriptome
Matthias Heinig, Michiel E. Adriaens, Sebastian Schafer, Hanneke W. M. van Deutekom, Elisabeth M. Lodder, James S. Ware, Valentin Schneider, Leanne E. Felkin, Esther E. Creemers, Benjamin Meder, Hugo A. Katus, Frank Rühle, Monika Stoll, François Cambien, Eric Villard, Philippe Charron, Andras Varro, Nanette H. Bishopric, Alfred L. George, Cristobal dos Remedios, Aida Moreno-Moral, Francesco Pesce, Anja Bauerfeind, Franz Rüschendorf, Carola Rintisch, Enrico Petretto, Paul J. Barton, Stuart A. Cook, Yigal M. Pinto, Connie R. Bezzina, Norbert Hubner   +30 more
doaj   +3 more sources

Automatic Segmentation and Disease Classification Using Cardiac Cine MR Images [PDF]

arXiv, 2017
Segmentation of the heart in cardiac cine MR is clinically used to quantify cardiac function. We propose a fully automatic method for segmentation and disease classification using cardiac cine MR images. A convolutional neural network (CNN) was designed to simultaneously segment the left ventricle (LV), right ventricle (RV) and myocardium in end ...
Isgum, Ivana, Leiner, Tim, Viergever, Max A., Wolterink, Jelmer M.   +3 more
arxiv   +12 more sources

Longitudinal quantile regression in presence of informative drop-out through longitudinal-survival joint modeling [PDF]

arXiv, 2014
We propose a joint model for a time-to-event outcome and a quantile of a continuous response repeatedly measured over time. The quantile and survival processes are associated via shared latent and manifest variables. Our joint model provides a flexible approach to handle informative drop-out in quantile regression.
Aalen, Andersen, Andrews, Buchinsky, Clements, Cowie, Cox, Daniel-Spiegel, Diggle, Doucet, Eickoff, Farcomeni, Farcomeni, Follmann, Geraci, Geraci, Geraci, Gilks, Gill, Henderson, Heritier, Hsieh, Kahaner, Keren, Koenker, Koenker, Kurland, Levine, Lipsitz, Little, Little, Liu, Liu, Merlo, Molenberghs, Ndrepepa, Nelder, Nelson, Nielsen, Rizopoulos, Rizopoulos, Rizopoulos, Rizopoulos, Sandri, Tsiatis, Verbeke, Verbeke, Viviani, Vonesh, Wei, Wu, Wu, Wu, Wulfsohn, Yi, Yu, Yuan   +56 more
arxiv   +3 more sources

Neonatal dilated cardiomyopathy

Revista Portuguesa de Cardiologia, 2017
Cardiomyopathies are rare diseases of the heart muscle, of multiple causes, that manifest with various structural and functional phenotypes but are invariably associated with cardiac dysfunction.
Paulo Soares, Gustavo Rocha, Susana Pissarra, Henrique Soares, Filipa Flôr-de-Lima, Sandra Costa, Cláudia Moura, Sofia Dória, Hercília Guimarães   +8 more
doaj   +4 more sources

Dilated cardiomyopathy [PDF]

Nature Reviews Disease Primers, 2019
Dilated cardiomyopathy (DCM) is a clinical diagnosis characterized by left ventricular or biventricular dilation and impaired contraction that is not explained by abnormal loading conditions (for example, hypertension and valvular heart disease) or coronary artery disease.
Schultheiss H. -P., Fairweather D. L., Caforio A. L. P., Escher F., Hershberger R. E., Lipshultz S. E., Liu P. P., Matsumori A., MAZZANTI, ANDREA, McMurray J., Priori S. G.   +10 more
openaire   +8 more sources

Dilated cardiomyopathy [PDF]

Circulation: Arrhythmia and Electrophysiology, 2013
Epidemiology, aetiology, pathophysiology, diagnosis, and therapy of patients with dilated cardiomyopathy are discussed. Recommendations on the use of CRT and ICD therapy by the ACC/AHA and ESC are presented.
Demosthenes G. Katritsis, Bernard J. Gersh, A. John Camm   +2 more
openaire   +3 more sources

OBSCN Mutations Associated with Dilated Cardiomyopathy and Haploinsufficiency [PDF]

, 2015
Studies of the functional consequences of DCM-causing mutations have been limited to a few cases where patients with known mutations had heart transplants.
Choi, O, Copeland, O, dos Remedios, C, Ehler, E, Knoll, R, Marston, SB, Messer, AE, Montgiraud, C, Munster, AB   +8 more
core   +17 more sources

Genetics of Dilated Cardiomyopathy

Annual Review of Medicine, 2021
Dilated cardiomyopathy (DCM) is defined as dilation and/or reduced function of one or both ventricles and remains a common disease worldwide. An estimated 40% of cases of familial DCM have an identifiable genetic cause. Accordingly, there is a fast-growing interest in the field of molecular genetics as it pertains to DCM. Many gene mutations have been
Matthew R.G. Taylor, Suet Nee Chen, Luisa Mestroni   +2 more
openaire   +4 more sources

Dilated cardiomyopathy

The Lancet, 2010
Dilated cardiomyopathy is characterised by left ventricular dilation that is associated with systolic dysfunction. Diastolic dysfunction and impaired right ventricular function can develop. Affected individuals are at risk of left or right ventricular failure, or both. Heart failure symptoms can be exercise-induced or persistent at rest.
Henry Knipe, Hani Salam
openaire   +3 more sources

Cardiomyopathy, familial dilated [PDF]

Orphanet Journal of Rare Diseases, 2006
AbstractDilated cardiomyopathy (DCM) is a heart muscle disease characterized by ventricular dilatation and impaired systolic function. Patients with DCM suffer from heart failure, arrhythmia, and are at risk of premature death. DCM has a prevalence of one case out of 2500 individuals with an incidence of 7/100,000/year (but may be under diagnosed).
Matthew R.G. Taylor, Luisa Mestroni, Elisa Carniel   +2 more
openaire   +4 more sources