Results 171 to 180 of about 310,703 (307)
Selective RyR2 inhibition reduces arrhythmia susceptibility in human cardiac slices
The Journal of Physiology, EarlyView.Abstract figure legend ent‐Vert selectively inhibits RyR2‐mediated sarcoplasmic reticulum (SR) Ca2+ leak and prevents triggered activity in human cardiac slices. A, in human ventricular slices exposed to β‐adrenergic stimulation with Iso and RyR2 sensitization with caffeine, RyR2 channels become hyperactive, leading to Ca2+ sarcoplasmic leak and ...
Micah K. Madrid +6 more
wiley +1 more source
Evaluation of red blood cell distribution width in cats with hypertrophic cardiomyopathy [PDF]
, 2015 Connolly, D J +3 more
core +1 more source
American Journal of Medical Genetics Part A, Volume 200, Issue 3, Page 661-672, March 2026.ABSTRACT Noonan Syndrome (NS) is a clinically and genetically heterogeneous condition characterized by typical facial dysmorphisms, short stature, congenital heart defects, and developmental delays. While variants in genes such as PTPN11, SOS1, and RAF1 account for most genetically confirmed cases, diagnosis is challenging due to phenotypic overlap ...
Gabriela Jeesoo Kim +9 more
wiley +1 more source
Adaptations to iron deficiency: cardiac functional responsiveness to norepinephrine, arterial remodeling, and the effect of beta-blockade on cardiac hypertrophy. [PDF]
, 2002 BackgroundIron deficiency (ID) results in ventricular hypertrophy, believed to involve sympathetic stimulation. We hypothesized that with ID 1) intravenous norepinephrine would alter heart rate (HR) and contractility, 2) abdominal aorta would be larger ...
Chew, Herbert George +8 more
core +1 more source
A Meta‐Analysis to Unveil the Diagnostic Gaps in Anderson–Fabry Disease in Women
Journal of Inherited Metabolic Disease, Volume 49, Issue 2, March 2026.ABSTRACT Anderson–Fabry disease (AFD) is an X‐linked lysosomal storage disorder caused by mutations in the GLA gene, leading to deficient α‐galactosidase A activity. Although historically considered a male disease, it is now recognized that heterozygous women can present with a wide range of symptoms. However, diagnosis in women remains challenging, as
L. Lenzini +6 more
wiley +1 more source
Journal of Magnetic Resonance Imaging, Volume 63, Issue 3, Page 859-871, March 2026.ABSTRACT Background A detailed evaluation of hemodynamics, supportive morphology, and deformation may help uncover the pathophysiology of hypertrophic obstructive cardiomyopathy (HOCM) and the changes wrought by alcohol septal ablation (ASA). Purpose To investigate the global cardiac volume, myocardial deformation, and hemodynamic characteristics ...
Kenichiro Suwa +5 more
wiley +1 more source
Nerve Ultrasound in Patients With Friedreich Ataxia
Muscle &Nerve, Volume 73, Issue 3, Page 395-402, March 2026.ABSTRACT Introduction/Aims Nerve enlargement has been reported in patients with Friedreich ataxia (FRDA). The underlying cause remains unclear, and both inflammatory processes and dysmyelination have been suggested as potential mechanisms. This study was aimed at assessing nerve morphology with high‐resolution ultrasound, to identify and describe ...
Katharina Kneer +9 more
wiley +1 more source
Sonography, Volume 13, Issue 1, March 2026.ABSTRACT Cardiac sonographers play a critical role in image acquisition and preliminary interpretation of echocardiography examinations. In New South Wales (NSW), cardiac sonographers frequently encounter the ethically complex and professionally challenging question from patients: “so, how does it look?” Despite their capacity to recognize significant ...
James Gregory Rendina Silcock
wiley +1 more source
Annals of Noninvasive Electrocardiology, Volume 31, Issue 2, March 2026.We developed CNN models using sinus rhythm ECG data from two institutions using distinct ECG systems. A fine‐tuned model trained on homogeneous datasets from cardiology departments consistently achieved high performance, whereas a model trained on heterogeneous datasets demonstrated lower performance.
Shinya Suzuki +17 more
wiley +1 more source