Results 191 to 200 of about 46,771 (265)

Chronic Viral Infections and Al Amyloidosis: An Uncommon Association

Clinical Case Reports, Volume 13, Issue 4, April 2025.
ABSTRACT AL‐amyloidosis is caused by deposition of pathological insoluble proteins in organs and tissues. HIV infection is a multi‐system disorder causing chronic inflammation. We report a case of AL‐amyloidosis associated with HIV suggesting that HIV‐associated immune dysregulation might be critical for pathogenesis of plasma cells dyscrasias and then
Alberto Palladini, Gabriele Cusumano, Ottavio Martellucci, Antonietta Gigante, Gabriella D'Ettorre, Maria Teresa Petrucci, Maurizio Muscaritoli, Mariangela Palladino   +7 more
wiley   +1 more source

Association Between Changes in Heart Rate and Adverse Events in Patients With Non‐Valvular Atrial Fibrillation: A Post Hoc Analysis of the J‐RHYTHM Registry

Clinical Cardiology, Volume 48, Issue 4, April 2025.
Excessive increases in heart rate (HR) and consistently high HR during follow‐up were independently associated with adverse events in patients with atrial fibrillation (AF); whereas, a modest decrease in HR was associated with lower mortality in those with a higher baseline HR. Changes in HR is important for AF management.
Eitaro Kodani, Takeshi Yamashita, Hiroshi Inoue, Hirotsugu Atarashi, Ken Okumura, Hideki Origasa, J‐RHYTHM Registry Investigators   +6 more
wiley   +1 more source

Global and Temporal Trends in Utilization and Outcomes of Implantable Cardioverter Defibrillators in Hypertrophic Cardiomyopathy. [PDF]

Circ Arrhythm Electrophysiol
Abdelfattah OM, Sayed A, Al-Jwaid A, Hassan A, Abu Jazar D, Narayanan A, Link MS, Martinez MW.   +7 more
europepmc   +1 more source

Hypertrophic cardiomyopathy. [PDF]

Heart, 1987
openaire   +2 more sources

p21‐Activated Kinase 1 (Pak1) as an Element in Functional and Dysfunctional Interplay Among the Myocardium, Adipose Tissue, and Pancreatic Beta Cells

Comprehensive Physiology, Volume 15, Issue 2, April 2025.
Pak1 regulates cardiac function, adipose tissue metabolism, and pancreatic β‐cell survival and function. Inflammation, oxidative stress, and Hippo signaling link Pak1 dysfunction across these tissues. Pak1 activators hold promise as potential therapeutic interventions. Images were created with a licensed version of BioRender.com.
Paola C. Rosas, R. John Solaro
wiley   +1 more source

Efficacy of cardiac myosin inhibitors mavacamten and aficamten in hypertrophic cardiomyopathy: a systematic review and meta-analysis of randomised controlled trials. [PDF]

Open Heart
Aman A, Akram A, Akram B, Maham M, Bokhari MZ, Akram A, Akram S, Yaqub F.   +7 more
europepmc   +1 more source

Involvement of S100A8 and S100A9 in nonischaemic cardiomyopathy

Clinical and Translational Discovery, Volume 5, Issue 2, April 2025.
1. S100 calcium binding proteins A8 and A9 (S100A8/A9) could be released from bone marrow (BM)‐ and non‐BM‐derived cells. 2. S100A8/A9 mainly activates the Toll‐like receptor 4 (TLR4) and receptors of advanced glycation endproducts (RAGE) signalling pathways and drives mitochondrial dysfunction, inflammation, reactive oxygen species production and ...
Qiu‐Yue Lin, Wen‐Xi Jiang, Hui‐Hua Li   +2 more
wiley   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Clinical Validity of Autosomal DominantALPK3Loss-of-function Variants as a Cause of Hypertrophic Cardiomyopathy

Hespe S, Singer ES, Reuter C, Murray B, Jordan E, Chowns J, Peters S, Mayers M, Gray B, Hershberger RE, Owens A, Semsarian C, Waddell A, Asatryan B, Owens E, Thaxton C, Adduru M, Anderson K, Brown EE, Hoffman-Andrews L, Stafford F, Bagnall RD, Bronicki L, Callewaert B, Chahal CAA, James CA, Jarinova O, Landstrom AP, McNally EM, Muiño-Mosquera L, Parikh V, Walsh R, Wayburn B, Ware JS, Parker BL, Porrello ER, Elliott DA, McNamara JW, Ingles J.   +38 more
europepmc   +1 more source