Results 41 to 50 of about 1,491 (172)

Beat‐to‐beat variability of ventricular repolarization reveals sex‐specific instability and proarrhythmic risk

The Journal of Physiology, EarlyView.
Abstract figure legend A mechanistic framework linking sex‐dependent dynamical instability to proarrhythmic risk. Sex‐specific human ventricular models show that upstream modulators, including biological sex, hormones, drugs and heart disease, promote steeper APD restitution in female than male and enhance dynamical instability.
Daisuke Sato, Lorenzo Santini, Raffaele Coppini, Eleonora Grandi   +3 more
wiley   +1 more source

Higher sensitivity to ouabain‐induced toxicity in human induced pluripotent stem cell‐derived cardiomyocytes than human adult heart tissue despite similar Na+/K+‐ATPase pump current amplitudes

British Journal of Pharmacology, Volume 183, Issue 11, Page 3093-3110, June 2026.
Abstract Background and Purpose Human induced pluripotent stem cell‐derived cardiomyocytes (hiPSC‐CM) have gained interest as a pharmacological model but their immaturity leads to uncertainty regarding translation. We studied the key player in maintaining ionic homeostasis, the Na+/K+‐ATPase (NKA), in hiPSC‐CM.
Djemail Ismaili, Paavo Virtanen, Junsoo Im, Paul Brunnbauer, Umber Saleem, Muhammed Ikbal Sönmez, Carl Schulz, Margaret Nandudu, Joris Winters, Cristina E. Molina, Johannes Petersen, Monika Stoll, Ulrich Schotten, Arne Hansen, Thomas Eschenhagen, Jussi T. Koivumäki, Torsten Christ   +16 more
wiley   +1 more source

Blood mRNA Expression Profiles of Autophagy, Apoptosis, and Hypoxia Markers on Blood Cardioplegia and Custodiol Cardioplegia Groups

Brazilian Journal of Cardiovascular Surgery, 2021
Introduction: Blood cardioplegia (BC) and Custodiol cardioplegia (CC) have been used for a long time in open heart surgery and are highly effective solutions.
Deniz Elcik, Aydın Tuncay, Elif Funda Sener, Serpil Taheri, Reyhan Tahtasakal, Ecmel Mehmetbeyoğlu, Isın Gunes, Omer Naci Emirogullari   +7 more
doaj   +1 more source

AP‐1‐Targeting Decoy Oligonucleotides: Mechanisms and Therapeutic Potential as Modulators of Inflammatory Pathways

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Numerous cellular functions, such as apoptosis, proliferation, differentiation, survival, transformation and cell migration, are regulated by a crucial transcription factor called activator protein 1 (AP‐1). Growing evidence indicates that AP‐1 is involved in severe conditions like fibrosis, cancer, and organ damage, as well as inflammatory ...
Maryam Mahjoubin‐Tehran, Samaneh Rezaei, Vasily N. Sukhorukov, Amin Jalili, Prashant Kesharwani, Amirhossein Sahebkar   +5 more
wiley   +1 more source

Effect of different cardioprotective methods on extracorporeal circulation in fetal sheep: a randomized controlled trial

Journal of Cardiothoracic Surgery, 2021
Background Congenital heart disease is a leading cause of death in newborns and infants. The feasibility of fetal cardiac surgery is linked to extracorporeal circulation (ECC); therefore, cardioplegic solutions need to be effective and long-lasting ...
Yi-bo Yan, Shuo Shi, Qian-biao Wu, Jin-sheng Cai, Bin-feng Lei   +4 more
doaj   +1 more source

Rescue Balloon Pulmonary Angioplasty Prior to Pulmonary Endarterectomy With Concomitant Mitral Valve Plasty in High‐Risk Operable CTEPH

Pulmonary Circulation, Volume 16, Issue 2, June 2026.
ABSTRACT Pulmonary endarterectomy (PEA) is a potentially curative treatment for chronic thromboembolic pulmonary hypertension (CTEPH); however, decompensated right heart failure and concomitant cardiac procedures increase the risk of postoperative mortality. We report a case of operable CTEPH with severe mitral regurgitation causing right heart failure
Keiichi Ishida, Nobutaka Ikeda, Seiichiro Sakao, Koichiro Sugimura, Ryuki Yamada, Norihisa Yuge, Susumu Manabe   +6 more
wiley   +1 more source

The use of blood and crystalloid cardioplegia in adult open-heart surgery on postsurgical outcomes: A systematic review of atrial fibrillation incidence, myocardial infarction, inotropic use, length of stay in ICU, and postoperative mortality

Bali Journal of Anesthesiology, 2022
Background: Myocardial ischemia can occur due to hypotension, shock, coronary heart disease, and aortic cross-clamping during open-heart surgery using a cardiopulmonary bypass machine. As the cardioprotective method, cardioplegia is classified into blood
Bambang Novianto Putro, Jefferson K Hidayat, Ratna Farida Soenarto   +2 more
doaj   +1 more source

Mitochondrial Ca2+ overload is a pivotal risk factor for lethal ventricular arrhythmias due to the oxidation of mitochondrial respirasome and energetic failure

British Journal of Pharmacology, Volume 183, Issue 7, Page 1404-1426, April 2026.
The data that support the findings of this study are available from the corresponding author upon reasonable request. Some data may not be made available because of privacy or ethical restrictions. Background and Purpose Ventricular arrhythmias are a leading cause of death among patients with cardiovascular diseases and are associated with elevated ...
Felipe de Jesús Salazar‐Ramírez, Luis Alberto Luévano‐Martínez, Abraham Méndez‐Fernández, Judith Bernal‐Ramírez, Carolina A. Morales‐Ochoa, Christian Silva‐Platas, Alfredo Cabrera‐Orefice, Ana C. Murrieta, José Luis Velasco‐Bolom, Gricelda Mendiola‐Garza, Flavio Contreras‐Torres, Guillermo Torre‐Amione, Ernesto A. Aiello, Gerardo García‐Rivas   +13 more
wiley   +1 more source

Efeitos das cardioplegias sangüínea e cristalóide no miocárdio hipertrófico de coelho: avaliação estrutural e ultra-estrutural Effects of myocardial protection in hypertrophic rabbit hearts: structural and ultra structural analysis

Brazilian Journal of Cardiovascular Surgery, 2007
OBJETIVO: Comparar e avaliar experimentalmente as alterações estruturais e ultra-estruturais em corações hipertrofiados isolados de coelhos submetidos à parada protegida pela solução de cardioplegia sangüínea e cardioplegia cristalóide.
Elthon Silveira Cressoni, Luiz Ernesto Avanci, Domingo Marcolino Braile, Ana Paula Marques Lima-Oliveira, Sebastião Roberto Taboga, Antonio Sérgio Martins, Rosa Sayoko Kawasaki Oyama, Marcos Aurélio Barbosa de Oliveira   +7 more
doaj   +1 more source

A Rare Case of Anterior Papillary Muscle Rupture Following Acute Non‐ST Elevation Myocardial Infarction

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Sudden hemodynamic deterioration after myocardial infarction should prompt immediate evaluation for papillary muscle rupture, even in the absence of a murmur or large‐vessel occlusion. Acute severe mitral regurgitation from papillary muscle rupture may mimic recurrent ischemia, and early echocardiography with prompt surgical intervention can ...
Biyas Thapa, Somee Rauniyar, Pratiksha Paudel   +2 more
wiley   +1 more source