Results 81 to 90 of about 3,870 (268)
Canonical or non‐canonical, all aspects of G protein‐coupled receptor kinase 2 in heart failure
Acta Physiologica, Volume 241, Issue 3, March 2025.Abstract G protein‐coupled receptor kinase 2 (GRK2) with its multidomain structure performs various crucial cellular functions under both normal and pathological conditions. Overexpression of GRK2 is linked to cardiovascular diseases, and its inhibition or deletion has been shown to be protective.
Abdullah Kaplan +5 more
wiley +1 more source
Acta Medica, 2002 Myocardial contractile function after cardioplegic arrest is often depressed and an ideal cardioplegic solution has not been developed yet. The aim of this study was to assess the efficacy of phosphodiesterase III inhibitors, amrinone and enoximone, and ...
Cengiz Köksal +3 more
doaj +1 more source
Thyroid Hormone as a Method of Reducing Damage to Donor Hearts after Circulatory Arrest [PDF]
, 2017 There is a chronic lack of donor hearts to meet the need for heart transplant both in the US and worldwide. Further, the use of available hearts is limited by the short period between collection and implantation during which the heart can be safely ...
Adams, William P.
core +1 more source
Normoxic cardiopulmonary bypass reduces oxidative myocardial damage and nitric oxide during cardiac operations in the adult [PDF]
, 1998 Objective: Hyperoxic cardiopulmonary bypass is widely used during cardiac operations in the adult. This management may cause oxygenation injury induced by oxygen-derived free radicals and nitric oxide.
Ihnken, Kai +7 more
core +1 more source
Eniluracil blocks AREG signalling‐induced pro‐inflammatory fibroblasts of melanoma in heart failure
ESC Heart Failure, Volume 12, Issue 1, Page 525-541, February 2025.Abstract Aims Heart failure (HF) is characterized by a heightened risk of melanoma, which often metastasizes to the heart. The overlap pathology between HF and melanoma includes chronic low‐grade inflammation and dysregulation of inflammatory cancer‐associated fibroblasts (iCAFs).
Qin Ran, Long Chen
wiley +1 more source
Topical use of antifibrinolytic agents reduces postoperative bleeding: a double-blind, prospective, randomized study [PDF]
, 2007 Objective: Postoperative bleeding is still one of the most common complications of cardiac surgery. Antifibrinolytic agents successfully reduce bleeding, but there are controversies concerning adverse effects after their systemic use.
Barić, Davor +7 more
core +1 more source
Unique pharmacological properties of etrasimod among S1P receptor modulators
FEBS Open Bio, Volume 15, Issue 1, Page 108-121, January 2025.Several S1P receptor modulators are being studied for treating immune‐mediated inflammatory diseases, each showing distinct selectivity and signaling activities. Downstream of S1P1, etrasimod showed similar potency to other S1P receptor modulators in promoting β‐arrestin recruitment and S1P1 internalization but was less potent in G protein activation ...
Ibragim Gaidarov +18 more
wiley +1 more source
Phosphorylation and translocation of heat shock protein 27 and αB-crystallin in human myocardium after cardioplegia and cardiopulmonary bypass [PDF]
, 2007 ObjectivesCardiac surgery using cardioplegia and cardiopulmonary bypass subjects myocardium to hypothermic reversible ischemic injury that can impair cardiac function.
Bianchi, Cesario +7 more
core +1 more source
The Journal of Physiology, Volume 603, Issue 2, Page 285-300, 15 January 2025.Abstract figure legend Schematic representation of the experimental workflow and main results of left and right ventricular outflows obtained before and after ablation of the pericardium, on isolated pig hearts perfused in biventricular working mode. Left and right ventricular haemodynamics were assessed in response to changes in left and right atrial ...
Fanny Vaillant +7 more
wiley +1 more source
Brazilian Journal of Cardiovascular Surgery, 1987 Foi avaliado, experimentalmente, o grau de proteção miocárdica oferecido por soluções cardioplégicas e hipotermia, à anóxia induzida pela interrupção do fluxo sangüíneo coronário em 20 cães. A isquemia miocárdica foi obtida através do pinçamento da aorta
Luis Alberto Dallan +6 more
doaj