Results 81 to 90 of about 3,809 (263)

Metabolomic Signatures Influenced by Different Cardioplegic Solutions in Cardiac Surgery

Journal of the Practice of Cardiovascular Sciences
Introduction: Cardioplegia is crucial for myocardial protection during cardiac surgery. However, the impact of different cardioplegia formulations on patients’ metabolomic responses has not been explored.
Chananya Karunasumetta, Chotika Chatgasem, Suriya Punchai, Kittisak Sawanyawisuth   +3 more
doaj   +1 more source

The behavior of Troponin I and CKMB mass in children who underwent surgical correction of congenital heart malformations Comportamento da troponina I e CK-MB massa em crianças submetidas a correção cirúrgica das cardiopatias congênitas

Brazilian Journal of Cardiovascular Surgery, 2003
OBJECTIVE: To analyze the behavior of troponin (TROP I) and CKMB mass (CKMBm) in regards to the addition of magnesium in cardioplegic solutions; and also the influence of per-operative factors.
Pedro Rafael Salerno, Fabio Biscegli Jatene, Patrícia Elias Figueiredo, Ieda Jatene Bosisio, Marcelo Biscegli Jatene, Magaly Arraes dos Santos, Luís Carlos Bento de Souza, Adib Domingos Jatene   +7 more
doaj   +1 more source

The slow component of the delayed rectifier potassium current in undiseased human ventricular myocytes [PDF]

, 2001
Objective: The purpose of this study was to investigate the properties of the slow component of the delayed rectifier potassium current (I-Ks) in myocytes isolated from undiseased human left ventricles.
Bogáts, Gábor, Jost, Norbert, Opincariu, M., Papp, Julius Gyula, Szenohradszky, Pál, Szolnoky, Jenő, Szécsi, J., Varró, András, Virág, László   +8 more
core   +1 more source

Association of plasma metabolites and cardiac mitochondrial function with heart failure progression

ESC Heart Failure, Volume 12, Issue 3, Page 2057-2065, June 2025.
Abstract Aims Plasma metabolites are prognostic in heart failure with reduced ejection fraction (HFrEF), with citric acid cycle metabolites linked to ejection fraction (EF) changes. We investigated these mechanisms in a canine chronic HFrEF model. We tested associations between changes in plasma metabolites, left ventricular (LV) end‐diastolic volume ...
Vandana Revathi Venkateswaran, Ruicong She, Stephen J. Gardell, Jasmine A. Luzum, Ramesh Gupta, Kefei Zhang, L. Keoki Williams, Hani N. Sabbah, David E. Lanfear   +8 more
wiley   +1 more source

2,3-Butanedione monoxime attenuates the β-adrenergic response of the L-type Ca2+ current in rat ventricular cardiomyocytes [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2016
Context: 2,3-Butanedione monoxime (BDM), an uncoupler of cardiac contraction, is commonly used in enzymatic dissociations to prevent hypercontraction of cardiomyocytes and in cardioplegic solutions to decrease oxygen demand during surgery.
Julio Alvarez-Collazo, Ana Iris López-Medina, Loipa Galán-Martínez, Julio L. Alvarez   +3 more
doaj  

Clinical testing of nicorandil supplemented normokalemic cardioplegic solution [PDF]

Interactive CardioVascular and Thoracic Surgery, 2006
Does nicorandil instead of supranormal potassium safely provide cardioplegia and cardioprotection in humans? Fifty patients eligible for coronary artery surgery were randomly divided into two groups; one group received standard St Thomas' Hospital solution (STHS) and the other group got a crystalloid solution in which supranormal potassium was replaced
Tor, Steensrud, Stig, Müller, Petter C, Endresen, Dag G, Sørlie   +3 more
openaire   +2 more sources

Machine Learning‐Driven Discovery of Structurally Related Natural Products as Activators of the Cardiac Calcium Pump SERCA2a

ChemMedChem, Volume 20, Issue 9, May 5, 2025.
Heart failure involves reduced SERCA2a activity, crucial for calcium regulation in heart cells. This study reports machine learning screening of 57,423 natural products, identifying several structurally related SERCA2a activators. Three compounds enhance calcium transport in cardiac cells, despite off‐target effects, offering promising hits for ...
Carlos Cruz‐Cortés, Eli Fernández‐de Gortari, Rodrigo Aguayo‐Ortiz, Jaroslava Šeflová, Adam Ard, Martin Clasby, Justus Anumonwo, L. Michel Espinoza‐Fonseca   +7 more
wiley   +1 more source

Improvement in short‐term outcome over time, in a single center embarking on a canine mitral valve repair program using a structured multidisciplinary approach

Veterinary Surgery, Volume 54, Issue 4, Page 675-685, May 2025.
Abstract Objective To describe a structured approach to the development of a mitral valve repair (MVR) program for dogs with myxomatous mitral valve disease (MMVD) and to document the change in short term outcome over time. Study design Clinical prospective study. Animals Dogs (n = 132) with MMVD undergoing MVR at a single hospital.
Daniel J. Brockman, Thomas D. Greensmith, Matteo Rossanese, Alison Young, Sarah L. Carey, Adrian Boswood, Thaleia‐Rengina Stathopoulou, Carolina Palacios Jimenez, Nigel Cross   +8 more
wiley   +1 more source

Ação da cardioplegia na proteção miocárdica: estudo experimental através das réplicas de criofraturas The cardioplegic action in the myocardial protection: experimental study through freeze fraction replictions

Brazilian Journal of Cardiovascular Surgery, 1987
Foi avaliado, experimentalmente, o grau de proteção miocárdica oferecido por soluções cardioplégicas e hipotermia, à anóxia induzida pela interrupção do fluxo sangüíneo coronário em 20 cães. A isquemia miocárdica foi obtida através do pinçamento da aorta
Luis Alberto Dallan, Sérgio Almeida de Oliveira, Lurdes Higuchi, Edgard A Lopes, Antônio Sesso, Geraldo Verginelli, Adib D Jatene   +6 more
doaj  

A Rare Case of Both Cardiac Myxoma and Left Coronary AVF, Diagnosis, and Management

Clinical Case Reports, Volume 13, Issue 4, April 2025.
ABSTRACT We present the case of a 62‐year‐old woman who was diagnosed with both cardiac myxoma and left coronary AVF, and we go on to discuss the course of her treatment and the outcome. In conclusion, this case study highlights the rare coexistence of an atrial myxoma and a congenital coronary arteriovenous fistula in a 65‐year‐old woman.
Isa Khaheshi, Hamed Askarpour, Seyyed Amirhossein Salehi, Atoosa Gharib   +3 more
wiley   +1 more source