Cardiopoietic stem cell therapy in ischaemic heart failure: long-term clinical outcomes [PDF]
ESC Heart Failure, 2020 Aims This study aims to explore long‐term clinical outcomes of cardiopoiesis‐guided stem cell therapy for ischaemic heart failure assessed in the Congestive Heart Failure Cardiopoietic Regenerative Therapy (CHART‐1) trial.
Bernard J Gersh, Marco Metra
exaly +7 more sources
Brachyury engineers cardiac repair competent stem cells. [PDF]
Stem Cells Translational Medicine, 2021 To optimize the regenerative proficiency of stem cells, a cardiopoietic protein‐based cocktail consisting of multiple growth factors has been developed and advanced into clinical trials for treatment of ischemic heart failure.
Andre Terzic, Ao Shi, Satsuki Yamada
exaly +4 more sources
Ventricular remodeling in ischemic heart failure stratifies responders to stem cell therapy [PDF]
Stem Cells Translational Medicine, 2020 Response to stem cell therapy in heart failure is heterogeneous, warranting a better understanding of outcome predictors. This study assessed left ventricular volume, a surrogate of disease severity, on cell therapy benefit.
Satsuki Yamada +5 more
doaj +3 more sources
Mass Customized Outlook for Regenerative Heart Failure Care [PDF]
International Journal of Molecular Sciences, 2021 Heart failure pathobiology is permissive to reparative intent. Regenerative therapies exemplify an emerging disruptive innovation aimed at achieving structural and functional organ restitution.
Andre Terzic +2 more
exaly +3 more sources
Guided Cardiopoiesis Enhances Therapeutic Benefit of Bone Marrow Human Mesenchymal Stem Cells in Chronic Myocardial Infarction [PDF]
Journal of the American College of Cardiology, 2010 ObjectivesThe goal of this study was to guide bone marrow-derived human mesenchymal stem cells (hMSCs) into a cardiac progenitor phenotype and assess therapeutic benefit in chronic myocardial infarction.BackgroundAdult stem cells, delivered in their ...
Andre Terzic +2 more
exaly +4 more sources
Congestive Heart Failure Cardiopoietic Regenerative Therapy (CHART-1) trial design [PDF]
European Journal of Heart Failure, 2016 Cardiopoiesis is a conditioning programme that aims to upgrade the cardioregenerative aptitude of patient-derived stem cells through lineage specification.
Bernard J Gersh +2 more
exaly +3 more sources
Stem cell therapy for heart failure: Ensuring regenerative proficiency [PDF]
Trends in Cardiovascular Medicine, 2016 Patient-derived stem cells enable promising regenerative strategies, but display heterogenous cardiac reparative proficiency, leading to unpredictable therapeutic outcomes impeding practice adoption.
Andre Terzic, Atta Behfar
exaly +4 more sources
A preview of selected articles. [PDF]
Stem Cells Transl Med, 2021 STEM CELLS Translational Medicine, Volume 10, Issue 3, Page 333-336, March 2021.
Atkinson SP.
europepmc +2 more sources
Secretome signature of cardiopoietic cells echoed in rescued infarcted heart proteome [PDF]
Stem Cells Translational Medicine, 2021 Stem cell paracrine activity is implicated in cardiac repair. Linkage between secretome functionality and therapeutic outcome was here interrogated by systems analytics of biobanked human cardiopoietic cells, a regenerative biologic in advanced clinical ...
D. Kent Arrell +11 more
doaj +2 more sources
Guided stem cell cardiopoiesis: Discovery and translation [PDF]
Journal of Molecular and Cellular Cardiology, 2008 Randy Faustino +2 more
exaly +2 more sources