Cardiopoietic cell therapy for advanced ischaemic heart failure: results at 39 weeks of the prospective, randomized, double blind, sham-controlled CHART-1 clinical trial. [PDF]
European Heart Journal, 2017 Cardiopoietic cells, produced through cardiogenic conditioning of patients' mesenchymal stem cells, have shown preliminary efficacy. The Congestive Heart Failure Cardiopoietic Regenerative Therapy (CHART-1) trial aimed to validate cardiopoiesis-based ...
Bernard J Gersh, Slobodan Obradovic
exaly +8 more sources
Cell Therapy Improves Quality-of-Life in Heart Failure: Outcomes From a Phase III Clinical Trial. [PDF]
Stem Cells Translational Medicine, 2023 : Patients with heart failure experience limitations in daily activity and poor quality-of-life. Prospective surveillance of health-related quality-of-life supplemented traditional death and hospitalization outcomes in the multinational, randomized ...
Marco Metra +2 more
exaly +4 more sources
Genomic chart guiding embryonic stem cell cardiopoiesis [PDF]
Genome Biology, 2008 Randy Faustino +2 more
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Cardiac Regenerative Medicine: The Potential of a New Generation of Stem Cells. [PDF]
Transfus Med Hemother, 2016 Cardiac stem cell therapy holds great potential to prompt myocardial regeneration in patients with ischemic heart disease. The selection of the most suitable cell type is pivotal for its successful application.
Cambria E +6 more
europepmc +2 more sources
A Nodal-to-TGFβ Cascade Exerts Biphasic Control Over Cardiopoiesis [PDF]
Circulation Research, 2012 Ke Wei, Mark Mercola, Erik Willems
exaly +2 more sources
Lineage specification of Flk-1 progenitors is associated with divergent Sox7 expression in cardiopoiesis [PDF]
Differentiation, 2009 Randy Faustino +2 more
exaly +2 more sources
Unleashing Cardiopoiesis: A Novel Role for G-CSF [PDF]
, 2010 Identifying pathways for cardiac muscle creation is a paramount objective of cardiac stem cell biology. In this issue of Cell Stem Cell, Shimoji and colleagues (2010) report the unforeseen ability of granulocyte colony-stimulating factor (G-CSF) to drive
Schneider, Michael D., Noseda, Michela
core +1 more source
Cardiac stem cell therapy: Current status
Journal of the Practice of Cardiovascular Sciences, 2017 Cardiac injury due to any cause leads to cardiac cell damage and thereby to ventricular dysfunction. Unlike current medical therapy, cardiac regeneration by stem cell therapy is a promising approach which has a potential to reverse left ventricular ...
Sridharan Umapathy
doaj +1 more source
Systems biology analysis of gene expression in cardiopoiesis [PDF]
, 2018 Myocardial infarction causes an irreversible loss of cardiac cells, frequently resulting in heart failure. Cardiac cell therapies using embryonic or adult stem cells offer promise to restore heart function. However, the convolution of molecular cues that
Leja, Tomasz
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Cardiovascular development signaling network within cardiopoietic cells
, 2011 Genes identified in Table 1 integrate into a network suggesting non-stochastic tendencies with emergent scale-free properties (top right). Examples of hubs, with number of first neighbor connections in parentheses, are labeled on the clustering ...
Randolph S Faustino (48222) +3 more
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