Results 21 to 30 of about 192 (165)

In‐depth analysis of the Sirtuin 5‐regulated mouse brain malonylome and succinylome using library‐free data‐independent acquisitions

PROTEOMICS, Volume 23, Issue 3-4, February 2023., 2023
Abstract Post‐translational modifications (PTMs) dynamically regulate proteins and biological pathways, typically through the combined effects of multiple PTMs. Lysine residues are targeted for various PTMs, including malonylation and succinylation. However, PTMs offer specific challenges to mass spectrometry‐based proteomics during data acquisition ...
Joanna Bons, Jacob Rose, Ran Zhang, Jordan B Burton, Christopher Carrico, Eric Verdin, Birgit Schilling   +6 more
wiley   +1 more source

Antioxidative Stress and Antiapoptosis Effect of Chitosan Nanoparticles to Protect Cardiac Cell Damage on Streptozotocin‐Induced Diabetic Rat

Oxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022., 2022
The antioxidant can inhibit oxidative stress and apoptosis, which has a role in an important mechanism on diabetic‐induced cardiac cell damage. The research goal was to prove the antioxidative stress and antiapoptosis effect of chitosan nanoparticles as a cardioprotector in streptozotocin‐induced diabetic rats.
Giftania Wardani, Jusak Nugraha, Mohd. Rais Mustafa, Rochmah Kurnijasanti, Sri Agus Sudjarwo, Massimo Lucarini   +5 more
wiley   +1 more source

In Vitro and In Vivo Cardioprotective Effects of Curcumin against Doxorubicin‐Induced Cardiotoxicity: A Systematic Review

Journal of Oncology, Volume 2022, Issue 1, 2022., 2022
Objective. This study aimed to review the potential chemoprotective effects of curcumin against the doxorubicin‐induced cardiotoxicity. Methods. According to the PRISMA guideline, a comprehensive systematic search was performed in different electronic databases (Web of Science, PubMed, and Scopus) up to July 2021.
Qian Zhang, Lei Wu, Achuthan Chathrattil Raghavamenon   +2 more
wiley   +1 more source

[Retracted] Grading Evaluation of Cardiotoxicity in Patients with Breast Cancer Treated with Adjuvant Paclitaxel Anthracycline/Cyclophosphamide Chemotherapy: A Meta‐Analysis

Computational and Mathematical Methods in Medicine, Volume 2022, Issue 1, 2022., 2022
Objective. The cardiac safety of concurrent treatment with anthracycline (A), cyclophosphamide (C), and paclitaxel (T) in an adjuvant BC treatment regimen is still under debate. In this study, we aimed to determine cardiotoxicity events following ACT chemotherapy among operable breast cancer patients without HER2‐positive. Methods.
Weibao Hu, Mengli Song, Linfeng Li, Ahmed Faeq Hussein   +3 more
wiley   +1 more source

Integrated Bioinformatics and Clinical Correlation Analysis of Key Genes, Pathways, and Potential Therapeutic Agents Related to Diabetic Nephropathy

Disease Markers, Volume 2022, Issue 1, 2022., 2022
Background. Diabetic nephropathy (DN) is a common microvascular complication of diabetes and a major cause of end‐stage renal disease, resulting in a substantial socioeconomic burden around the world. Some unknown biomarkers, mechanisms, and potential novel agents regarding DN are yet to be identified. Methods.
Shengnan Chen, Lei Chen, Hongli Jiang, Changli Zhou   +3 more
wiley   +1 more source

Novel Molecular Targets Participating in Myocardial Ischemia-Reperfusion Injury and Cardioprotection. [PDF]

Cardiol Res Pract, 2019
Worldwide morbidity and mortality from acute myocardial infarction (AMI) and related heart failure remain high. While effective early reperfusion of the criminal coronary artery after a confirmed AMI is the typical treatment at present, collateral myocardial ischemia‐reperfusion injury (MIRI) and pertinent cardioprotection are still challenging to ...
Liu NB, Wu M, Chen C, Fujino M, Huang JS, Zhu P, Li XK.   +6 more
europepmc   +2 more sources

Mitochondrial biogenesis: An update

Journal of Cellular and Molecular Medicine, Volume 24, Issue 9, Page 4892-4899, May 2020., 2020
Abstract In response to the energy demand triggered by developmental signals and environmental stressors, the cells launch the mitochondrial biogenesis process. This is a self‐renewal route, by which new mitochondria are generated from the ones already existing.
Lucia‐Doina Popov
wiley   +1 more source

Disribution kinetics of cardioprotector ALM-802 in rat organs and tissues

Pharmacokinetics and Pharmacodynamics, 2022
The distribution kinetics of a compound with cardioprotective activity, N1-(2,3,4-trimethoxybenzyl)-N2-{2-[(2,3,4-trimethoxybenzyl)amino] ethyl}-1,2-ethanediamine (ALM-802) in rat tissues and organs after single intragastric administration at a dose of 100 mg/kg. The values of ALM-802 tissue availability were determined.
O. Yu. Kravtsova, G. B. Kolyvanov, A. A. Litvin, P. O. Bochkov, V. P. Zherdev   +4 more
openaire   +2 more sources

Potential Therapeutic Role of Purinergic Receptors in Cardiovascular Disease Mediated by SARS‐CoV‐2

Journal of Immunology Research, Volume 2020, Issue 1, 2020., 2020
Novel coronavirus disease 2019 (COVID‐19) causes pulmonary and cardiovascular disorders and has become a worldwide emergency. Myocardial injury can be caused by direct or indirect damage, particularly mediated by a cytokine storm, a disordered immune response that can cause myocarditis, abnormal coagulation, arrhythmia, acute coronary syndrome, and ...
Fernanda dos Anjos, Júlia Leão Batista Simões, Charles Elias Assmann, Fabiano Barbosa Carvalho, Margarete Dulce Bagatini, Ravirajsinh Jadeja   +5 more
wiley   +1 more source

ПРИМЕНЕНИЕ НИКОРАНДИЛА ПРИ СЕРДЕЧНО-СОСУДИСТЫХ ЗАБОЛЕВАНИЯХ И ОПТИМИЗАЦИЯ СХЕМ ЕГО НАЗНАЧЕНИЯ

Архивъ внутренней медицины, 2012
Nicorandil is a dual pharmacological mechanism anti-anginal agent with adenosinetriphosphat-esensitive potassium (Кatp) channel agonist and nitrate-like properties.
Ю. Б. Белоусов
doaj   +1 more source