Results 211 to 220 of about 3,273,209 (295)
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1984
Publisher Summary This chapter mainly discusses the major developments of new inotropic agents over the last three years. Compounds that are not reviewed are glucagon, anthopleurin,g ionophores, the cardiotonic principles of ginger, a newly synthesized analog of PGI2, and SKF 86466, a selective α2-adrenoceptor agonist.
Bernd Wetzel, Norbert Hauel
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Publisher Summary This chapter mainly discusses the major developments of new inotropic agents over the last three years. Compounds that are not reviewed are glucagon, anthopleurin,g ionophores, the cardiotonic principles of ginger, a newly synthesized analog of PGI2, and SKF 86466, a selective α2-adrenoceptor agonist.
Bernd Wetzel, Norbert Hauel
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Synthesis of Amrinone, A Cardiotonic Agent
Journal of the Chinese Chemical Society, 1988AbstractA new synthesis of amrinone, 1, from 5‐(4‐pyridinyl) −2(1H)‐pyridone, 5, is reported. Nitration at C‐3 of the pyridone ring of 5 followed by reduction afforded amrinone. Another synthetic route was also carried out by bromination at C‐3 of the pyridone ring of 5 followed by substitution with sodium azide to give the corresponding azide ...
Min‐Jen Shiao +2 more
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Cardiovascular Pharmacology of the Vasodilator-Cardiotonic Agent, 349U85
Journal of Cardiovascular Pharmacology, 1992349U85 is a chemically novel, nonglycoside, noncatecholamine cardiotonic-vasodilator agent with a unique cardiovascular profile in vitro and in vivo. 349U85 and milrinone, 10(-6) to 3 x 10(-5) M each, produce concentration-dependent increases in tension development of 33-60% and 37-60%, respectively, with corresponding 5-18% and 17-55% increases in ...
R P, Steffen, W B, Wastila
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Cardiotonic agents and the sodium transient
Trends in Pharmacological Sciences, 1981Abstract The authors discuss the possible link between membrane excitation and the calcium transient in cardiac muscle.
Tai Akera, Theodore M. Brody
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Cardiotonic Agent SCH00013 Prolongs Survival of Cardiomyopathic Hamsters
Journal of Cardiovascular Pharmacology, 2003The authors examined the effects of long-term treatment with SCH00013, a novel cardiotonic agent with calcium-sensitizing action, on survival of hereditary cardiomyopathic BIO 14.6 hamsters. Sixty-nine male hamsters at 223 days of age were divided into untreated, SCH00013-low (approximately 1 mg/kg/d), and SCH00013-high (approximately 10 mg/kg/d ...
Tadahito, Narita +4 more
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European Journal of Pharmacology, 1987
The effect on the contractile protein system of MCI-154, a novel and potent cardiotonic agent, was examined by using thin bundles of chemically skinned fibers from the guinea-pig papillary muscles. MCI-154 increased the Ca2+ sensitivity of the contractile protein system of the cardiac skinned fibers.
Y, Kitada +3 more
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The effect on the contractile protein system of MCI-154, a novel and potent cardiotonic agent, was examined by using thin bundles of chemically skinned fibers from the guinea-pig papillary muscles. MCI-154 increased the Ca2+ sensitivity of the contractile protein system of the cardiac skinned fibers.
Y, Kitada +3 more
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Annales de cardiologie et d'angeiologie, 1986
The possibilities for therapy in the field of severe cardiac insufficiency have been extended in recent years by the introduction of novel agents endowed with a positive inotropic action. These substances may be arranged in two large classes: sympathomimetic agents and "non sympathomimetic--non digitalis-like" inotropic agents.
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The possibilities for therapy in the field of severe cardiac insufficiency have been extended in recent years by the introduction of novel agents endowed with a positive inotropic action. These substances may be arranged in two large classes: sympathomimetic agents and "non sympathomimetic--non digitalis-like" inotropic agents.
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Cardiovascular Properties of a New Cardiotonic Agent, MDL 19205
Journal of Cardiovascular Pharmacology, 1984The cardiovascular properties of a new cardiotonic agent, MDL 19205, were investigated in anesthetized and conscious dogs and in a dog heart-lung preparation. MDL 19205 (0.1-1 mg/kg), administered to anesthetized dogs by intravenous injection, produced a dose-related increase in cardiac contractile force lasting up to 1 h. It also produced a relatively
R C, Dage +3 more
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Scaffold evaluation of liguzinediol analogs as novel cardiotonic agents.
Pharmazie, 2013Z. Liu +8 more
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