Results 221 to 230 of about 3,273,209 (295)

[Membranotropic action of cardiotonic agents and ubiquinone].

Ukrainskii biokhimicheskii zhurnal (1978), 1991
Interaction of cardiotonic drugs (strophantidine acetate, suphan, para-oxybenzoic acid) and ubiquinone with phospholipid bilayers has been studied. Exothermic effect of the reaction followed by an increase in microviscosity and hydrophobicity of the bilayer from cardiolipin, but by a decrease of the microviscosity of the bilayer from lecithin has been ...
I S, Chekman, A G, Goriushko, I Iu, Mel'nik, L G, Sachenko   +3 more
openaire   +1 more source

Identification and characterization of isoenzymes of cyclic nucleotide phosphodiesterase in human kidney and heart, and the effects of new cardiotonic agents on these isoenzymes

Naunyn-Schmiedeberg's Archives of Pharmacology, 1994
M. Sugioka, Masa-aki Ito, H. Masuoka, K. Ichikawa, T. Konishi, Toshio Tanaka, T. Nakano   +6 more
semanticscholar   +1 more source

Cardiotonic agents. Synthesis and inotropic activity of a series of isoquinolin-3-ol derivatives.

Journal of Medicinal Chemistry, 1988
R. Kanojia, J. Press, O. W. Lever, L. Williams, J. Mcnally, A. Tobia, R. Falotico, J. Moore   +7 more
semanticscholar   +1 more source

Calcium Signaling and Pharmacology of Cardiotonic Agents

1995
The mechanisms of action of drugs that act on myocardial contractility through different signal transduction pathways have lately been elucidated to a great extent, in particular since the introduction of novel methods for detecting changes in the intracellular concentration of Ca++ ions, ([Ca++] i), by the application of aequorin, quin-2, fura-2 and ...
openaire   +1 more source

Inosine : a naturally occurring cardiotonic agent.

Journal de pharmacologie, 1984
For many years, Inosine was considered to be a simple metabolite of adenosine which was devoid of any cardiovascular effects. This theoretical ineffectiveness can be explained in the light of recent studies by the use of inadequate doses. In fact, higher doses of inosine, a non-toxic nucleoside, have demonstrated, experimentally, a cardiovascular ...
openaire   +1 more source

The effect of several “new and novel” cardiotonic agents on key subcellular processes involved in the regulation of myocardial contractility: Implications for mechanism of action

, 1983
R. Weishaar, M. Quade, D. K. Boyd, J. Schenden, S. Marks, H. R. Kaplan   +5 more
semanticscholar   +1 more source

Relative toxicity of cardiotonic agents

Cardiovascular Toxicology, 2007
J. Burniston, G. Ellison, W. Clark, D. Goldspink, L. Tan   +4 more
semanticscholar   +1 more source

A novel class of cardiotonic agents: synthesis and biological evaluation of 5-substituted 3,6-dihydrothiadiazin-2-ones with cyclic AMP phosphodiesterase inhibiting and myofibrillar calcium sensitizing properties.

Journal of Medicinal Chemistry, 1992
M. Forest, P. Lahouratate, M. Martín, G. Nadler, M. Quiniou, R. Zimmermann   +5 more
semanticscholar   +1 more source

[New cardiotonic/inodilator agents: energetic aspects].

Zeitschrift fur Kardiologie, 1993
Inotropic agents alter myocardial oxygen consumption by influencing heart rate, by influencing preload and afterload due to vasodilation, and by direct effects on the myocardium. The latter critically depend on the pharmacologic mode of action. Inotropic agents which act by increasing cyclic AMP in the failing human myocardium increase myocardial ...
openaire   +1 more source

[Value and limitations of new cardiotonic agents].

Bulletin de l'Academie nationale de medecine, 1989
New cardiotonic agents are an original approach in the treatment of severe heart failure. They can be classified into two groups: --beta-adrenergic agonists which stimulate beta-adrenergic receptors and, therefore, increase cyclic AMP production and intracellular calcium concentration; --phosphodiesterase inhibitors which block the cyclic AMP ...
Y, Grosgogeat, M, Komajda
openaire   +1 more source