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ChemInform Abstract: Synthesis of Milrinone (I), a Cardiotonic Agent.
ChemInform, 1990A new synthesis of milrinone from 6-methyl-5-(4-pyridinyl)-2(1H)-pyridone is reported. A convenient synthesis of 3,4'-bipyridines is achieved. They can be converted into pyridone by hydrogenolysis and hydrolysis, respectively.
Chieh-Fu Chen +2 more
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Synthesis of Amrinone, A Cardiotonic Agent
Journal of the Chinese Chemical Society, 1988AbstractA new synthesis of amrinone, 1, from 5‐(4‐pyridinyl) −2(1H)‐pyridone, 5, is reported. Nitration at C‐3 of the pyridone ring of 5 followed by reduction afforded amrinone. Another synthetic route was also carried out by bromination at C‐3 of the pyridone ring of 5 followed by substitution with sodium azide to give the corresponding azide ...
Min-Jen Shiao, Puh Shieh, Jen-Shiow Lai
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Cardiotonic agents and the sodium transient
Trends in Pharmacological Sciences, 1981Abstract The authors discuss the possible link between membrane excitation and the calcium transient in cardiac muscle.
Theodore M. Brody, Tai Akera
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New cardiotonic agents — a promising approach for treatment of heart failure [PDF]
Trends in Pharmacological Sciences, 1988 Abstract Congestive heart failure is a common disorder with extremely high mortality rate. Its incidence is steadily increasing. Therapy is directed towards reduction of vascular resistance, reduction of circulating blood volume and stimulation of myocardial contractility.
Norbert Hauel, Bernd Wetzel
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Cardiotonic agents in the management of chronic cardiac failure
American Heart Journal, 1982Heart failure is a syndrome with distinct clinical signs and symptoms. The severity of cardiac failure and a deterioration in functional capacity can be determined by a progressive exercise test and by the noninvasive determination of maximum oxygen uptake.
Karl T. Weber +2 more
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The therapeutic potential of novel cardiotonic agents
Expert Opinion on Investigational Drugs, 2003During the course of treatment of heart failure patients, cardiotonic agents are inevitable for improvement of myocardial dysfunction. Clinically available agents, such as beta-adrenoceptor agonists and selective phosphodiesterase 3 inhibitors, act mainly via cyclic AMP/protein kinase A-mediated facilitation of Ca(2+) mobilisation (upstream mechanism).
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European Journal of Pharmacology, 1987
The effect on the contractile protein system of MCI-154, a novel and potent cardiotonic agent, was examined by using thin bundles of chemically skinned fibers from the guinea-pig papillary muscles. MCI-154 increased the Ca2+ sensitivity of the contractile protein system of the cardiac skinned fibers.
Noriko Matsumura +3 more
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The effect on the contractile protein system of MCI-154, a novel and potent cardiotonic agent, was examined by using thin bundles of chemically skinned fibers from the guinea-pig papillary muscles. MCI-154 increased the Ca2+ sensitivity of the contractile protein system of the cardiac skinned fibers.
Noriko Matsumura +3 more
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1984
Publisher Summary This chapter mainly discusses the major developments of new inotropic agents over the last three years. Compounds that are not reviewed are glucagon, anthopleurin,g ionophores, the cardiotonic principles of ginger, a newly synthesized analog of PGI2, and SKF 86466, a selective α2-adrenoceptor agonist.
Bernd Wetzel, Norbert Hauel
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Publisher Summary This chapter mainly discusses the major developments of new inotropic agents over the last three years. Compounds that are not reviewed are glucagon, anthopleurin,g ionophores, the cardiotonic principles of ginger, a newly synthesized analog of PGI2, and SKF 86466, a selective α2-adrenoceptor agonist.
Bernd Wetzel, Norbert Hauel
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Calcium Signaling and Pharmacology of Cardiotonic Agents [PDF]
, 1995 The mechanisms of action of drugs that act on myocardial contractility through different signal transduction pathways have lately been elucidated to a great extent, in particular since the introduction of novel methods for detecting changes in the intracellular concentration of Ca++ ions, ([Ca++] i), by the application of aequorin, quin-2, fura-2 and ...
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Analysis of the efficacy of the new cardiotonic agent TA-064
American Heart Journal, 1985TA-064 is a new cardiotonic agent which is also effective orally, according to investigations conducted in Japan. We analyzed computer-assisted alterations of pressure-volume relationships serially and of indirect myocardial oxygen consumption (MVO2) estimations on line during TA-064 influence in 16 patients with congestive cardiomyopathy: left ...
Helmut Neuss +5 more
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