Results 41 to 50 of about 2,636,084 (314)

Cardiovascular diseases, risk factors and barriers in their prevention in Croatia [Kardiovaskularne bolesti, rizični faktori i zapreke za prevenciju u Hrvatskoj] [PDF]

, 2009
Cardiovascular diseases are the leading cause of death in Croatia, with significant regional differences. Despite high mortality rates, high prevalence of various cardiovascular risk factors and well organized public health network, comprehensive system ...
Andrić, Adriana, Džakula, Aleksandar, Juriša, Adriana, Polašek, Ozren, Radaković, Nikolina, Todorović, Goran, Šogorić, Selma   +6 more
core  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Workplace-based primary prevention intervention reduces incidence of hypertension: a post hoc analysis of cluster randomized controlled study

BMC Medicine, 2023
Background A workplace-based primary prevention intervention be an effective approach to reducing the incidence of hypertension (HTN). However, few studies to date have addressed the effect among the Chinese working population.
Zhen Hu, Xin Wang, Conglin Hong, Congyi Zheng, Linfeng Zhang, Zuo Chen, Haoqi Zhou, Yixin Tian, Xue Cao, Jiayin Cai, Runqing Gu, Ye Tian, Lan Shao, Zengwu Wang   +13 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Cardiovascular Diseases

, 2019
Cross-sectional imaging techniques—echocardiography, CT, MRI and nuclear medicine—are the diagnostic tools of choice for the diagnosis and workup of cardiovascular disease. Machine learning and deep learning in particular will have a fundamental and lasting impact on all of these modalities.
Verjans, Johan, Veldhuis, Wouter B., Carneiro, Gustavo, Wolterink, Jelmer M., Išgum, Ivana, Leiner, Tim   +5 more
openaire   +3 more sources

Patient and Disease-Specific Induced Pluripotent Stem Cells for Discovery of Personalized Cardiovascular Drugs and Therapeutics. [PDF]

, 2020
Human induced pluripotent stem cells (iPSCs) have emerged as an effective platform for regenerative therapy, disease modeling, and drug discovery.
Chandy, Mark, Paik, David T, Wu, Joseph C   +2 more
core  

Increased consumption of fruit and vegetables for the primary prevention of cardiovascular diseases [PDF]

, 2013
There is increasing evidence that high consumption of fruit and vegetables is beneficial for cardiovascular disease (CVD ...
Ajzen, Ali, Ammerman, Anderson, Appel, Asgard, Bandura, Bazzano, Beresford, Blum, Broekmans, Brug, Brunner, Burchett, Carter, Chen, Clark, Contento, Dauchet, Djuric, Djuric, Duyn, Egger, Fielding, Finley, Fuemmeler, Fujioka, Ganann, Gardner, George, Gravel, Groen, Havas, Hooper, Howard, John, Joshipura, Law, Lehtonen, Lennernäs, Liu, Liu, Lock, Lutz, Maheswaran, Maskarinec, Miller, Müller-Nordhorn, Ness, Nomikos, Ogden, Peterson, Pollard, Pomerleau, Prochaska, Robinson, Rock, Rosenstock, Sacks, Scarborough, Singh, Smith-Warner, Sorensen, Staten, Steptoe, Suido, Svetkey LP, Takai, Teeple, Thies, Thompson, Tobias, U.S. Department of Agriculture, Verlangieri, Wallace, Wang, White E, Winham, Wolfenden, Yarmohammadi, Yusuf   +80 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Diabetic Cardiovascular Disease Induced by Oxidative Stress. [PDF]

, 2015
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality among patients with diabetes mellitus (DM). DM can lead to multiple cardiovascular complications, including coronary artery disease (CAD), cardiac hypertrophy, and heart failure
Adam, Matti, Jagger, Ann, Kayama, Yosuke, Raaz, Uwe, Sakamoto, Masaya, Schellinger, Isabel N, Spin, Joshua M, Suzuki, Hirofumi, Toyama, Kensuke, Tsao, Philip S   +9 more
core   +2 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source