Results 71 to 80 of about 11,998,196 (407)

Drug treatment of hypertension: focus on vascular health [PDF]

, 2016
Hypertension, the most common preventable risk factor for cardiovascular disease and death, is a growing health burden. Serious cardiovascular complications result from target organ damage including cerebrovascular disease, heart failure, ischaemic heart
Cameron, Alan C., Lang, Ninian N., Touyz, Rhian M.   +2 more
core   +1 more source

Association between insulin resistance and the development of cardiovascular disease

Cardiovascular Diabetology, 2018
For many years, cardiovascular disease (CVD) has been the leading cause of death around the world. Often associated with CVD are comorbidities such as obesity, abnormal lipid profiles and insulin resistance.
V. Ormazábal, Soumyalekshmi Nair, Omar Elfeky, C. Aguayo, C. Salomon, F. Zúñiga   +5 more
semanticscholar   +1 more source

Lipoprotein(a) in Cardiovascular Diseases [PDF]

BioMed Research International, 2013
Lipoprotein(a) (Lp(a)) is an LDL-like molecule consisting of an apolipoprotein B-100 (apo(B-100)) particle attached by a disulphide bridge to apo(a). Many observations have pointed out that Lp(a) levels may be a risk factor for cardiovascular diseases.
Malaguarnera M, Vacante M, Russo C, Malaguarnera G, Antic T, MALAGUARNERA, Lucia, BELLA, Rita, PENNISI, Giovanni, GALVANO, Fabio, Frigiola A.   +9 more
openaire   +3 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Cardiovascular diseases, risk factors and barriers in their prevention in Croatia [Kardiovaskularne bolesti, rizični faktori i zapreke za prevenciju u Hrvatskoj] [PDF]

, 2009
Cardiovascular diseases are the leading cause of death in Croatia, with significant regional differences. Despite high mortality rates, high prevalence of various cardiovascular risk factors and well organized public health network, comprehensive system ...
Andrić, Adriana, Džakula, Aleksandar, Juriša, Adriana, Polašek, Ozren, Radaković, Nikolina, Todorović, Goran, Šogorić, Selma   +6 more
core  

Nutrition and cardiovascular disease [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2007
This chapter looks at the correlation between nutrition and cardiovascular disease. The most common and pertinent cardiovascular diseases are myocardial infarction, stroke, peripheral vascular disease, and hypertension, which serve as a major risk factor for myocardial infarction and stroke.
Godfrey S. Getz, Catherine A. Reardon
openaire   +2 more sources

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Improvement of heart rate recovery after exercise training in older people. [PDF]

, 2005
Twenty-four subjects aged 70 and older were retrospectively selected from our archives and screened for symptoms of cardiovascular disease. Baseline exercise test was negative for myocardial ischemia in all subjects.
De Lorenzo A., DEL FORNO, DOMENICO, Giallauria F., Lucci R., Manakos A., Pilerci F., VIGORITO, CARLO   +6 more
core   +1 more source

Four new mutations in the apolipoprotein B gene causing hypobetalipoproteinemia, including two different frameshift mutations that yield truncated apolipoprotein B proteins of identical length.

Journal of Lipid Research, 1993
Familial hypobetalipoproteinemia can be caused by mutations in the apolipoprotein (apo)B gene that interfere with the translation of a full-length apoB molecule. Frequently, a truncated apoB molecule can be detected in the plasma lipoproteins of affected
SG Young, CR Pullinger, BR Zysow, H Hofmann-Radvani, MF Linton, RV Farese, Jr, JF Terdiman, SM Snyder, SM Grundy, GL Vega   +9 more
doaj   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source